@AndrewTosolini

Senior Researcher @Ngo_Lab + @Steyn_Lab; @SchiavoMNPlab alumni. Passions = #MNDresearch + @ChelseaFC + @Socceroos

 Brisbane, Australia
Joined May 2011
  • Tweets1.2K
  • Following1.2K
  • Followers615
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🧠🔬 Delighted to share work led by @ellierhymes #IntravitalImaging of #NeurotrophicFactors shows #CNTF selectively slows #AxonalTransport in motor neurons Great collab with @SchiavoMNPlab & James Sleigh @braincomms @UQ_News @UCLQSMNDCentre @UCLIoN academic.oup.com/braincomms/…

Ciliary neurotrophic factor slows axonal transport of signalling endosomes

Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo. These fi

academic.oup.com
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Really pleased for David and Chloe to see this published. Was a great collaboration #ALS #MND #SOD1 #metabolicdysfunction @SchiavoMNPlab @UCLQSMNDCentre
@BrainComms@braincommsSep 24
Thompson et al. report the generation and characterization of novel gene-edited mice expressing the human superoxide dismutase 1 (SOD1) gene and carrying the pathogenic SOD1A5V mutation associated with amyotrophic lateral sclerosis. Read it at 👉buff.ly/J8mz8dt #ALS
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Andrew Tosolini retweeted
@BrainComms@braincommsSep 27
Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo, highlighting how neurotrophic factors regulate axonal transport and motor neuron connectivity. Read it at 👉buff.ly/jfwxif1
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Andrew Tosolini retweeted
Dave Arnold@DaveArnoldLabJul 10
It is finally out! JCI - Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition jci.org/articles/view/190646
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Congrats to @Jobby1kanobi, @annaleighbrown2, and @KaiSun59997752 on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the phosphoproteome. Beautiful cover art too! @SchiavoMNPlab @FrattaLab @The_SERIOus_Dr science.org/doi/10.1126/scis…

Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regener...

BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.

science.org
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Recently published work lead by the very talented @DVillarroelC. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @SchiavoMNPlab @FrattaLab @Jobby1kanobi #axonaltransport #Rab7 #motorneurons #TBK1
LifeScienceAlliance@LSAjournalFeb 5
Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7. life-science-alliance.org/co…
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Do all #NTFs regulate #MotorNeuron axonal transport? Our new preprint shows they do not. #BDNF enhances (shorturl.at/siwFi), #CNTF slows. #HGF, #NRTN & #proBDNF show no effect. #AxonalTransport regulation is selective, not universal. @UCLIoN @SchiavoMNPlab @ellierhymes
bioRxiv Neuroscience@biorxiv_neursci10 Oct 2025
CNTF specifically slows down the axonal transport of signalling endosomes biorxiv.org/content/10.1101/… #biorxiv_neursci

CNTF specifically slows down the axonal transport of signalling endosomes

Efficient axonal transport is essential for maintaining neuronal function, enabling the bidirectional delivery of diverse cargoes between the cell body and distal compartments. In the neuromuscular...

biorxiv.org
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Such a great initiative to support @MNDFoundation. Tasty too! Well done @BellissimoAU #MND #ALS #Coffee #Blend9 @mndaustralia
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Thanks to the whole team, showcasing all the research at the newly opened centre for MND research #uq_cmndr. Congratulations to @NgoShyuan and @Fred_Steyn for making their dream reality. Always helping people living with #mnd as priority @UQ_News
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Andrew Tosolini retweeted
Ilary Allodi@AllodiLab3 Jul 2025
An MRC funded postdoctoral position is available in my lab at University of St Andrews starting from September 2025. For more details and applications visit: vacancies.st-andrews.ac.uk/V… Applications closing date: 31 July 2025
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Andrew Tosolini retweeted
AIBN Research@AIBNatUQ4 Jul 2025
Meet A/Prof Shyuan Ngo (@NgoShyuan ), or ‘Shu’ as she’s widely known 👋 AIBN researcher, community advocate, & driving force behind QLD’s newest effort to tackle #MND. Read about her journey & the new Centre set to transform MND research in Queensland: buff.ly/AprcSSh
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The official opening for the UQ centre for MND is THIS Friday! Please register via biomedical-sciences.uq.edu.a… Please note due to popularity, our lab tours are FULL @MNDFoundation @MNDQueensland @UQ_SCMB @QldBrainInst @UQscience @UQ_News
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🚨New @biorxivpreprint collab b/w Fisher, Cunningham, Gilthorpe & @SchiavoMNPlab @MRCHarwell @UCLIoN @umeauniversity. Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel genomically humanised SOD1A4V mice. biorxiv.org/content/10.1101/…

Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel genomically...

Amyotrophic lateral sclerosis (ALS) caused by mutation in superoxide dismutase 1 ( SOD1 ) accounts for 15-30% of familial ALS and is typically autosomal dominant. How single base pair/amino acid...

biorxiv.org
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📣 PhD Opportunity in Mathematical Modelling at The University of Queensland @UQ_News
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Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis nature.com/articles/s41593-0…

Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis

Nature Neuroscience - Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in...

nature.com
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Andrew Tosolini retweeted
Hilliard Lab@HilliardLab20 Feb 2025
Do not miss out on this amazing meeting! The deadline for abstract submission and registration is March 1st. Check out the program and apply now: meetings.embo.org/event/25-c… #EMBOcellBioComm @EMBO
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Andrew Tosolini retweeted
ShorterLab@ShorterLab15 Feb 2025
Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated Neurodegeneration - San Gil - BioEssays - Wiley Online Library onlinelibrary.wiley.com/doi/…

Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated Neurodegeneration

Early mechanisms of TDP-43-mediated neurodegeneration are the key to unlocking novel precision medicine and biomarkers for amyotrophic lateral sclerosis and frontotemporal dementia.

onlinelibrary.wiley.com
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Andrew Tosolini retweeted
PACTALS@pactals31 Jan 2025
PACTALS 2025 will be held in Melbourne from 7-9 September 2025. Abstract submissions are now open. @mndaustralia @ALSMNDAlliance @NgoShyuan @nervecentrals pactalscongress.com/
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Andrew Tosolini retweeted
FightMND@FightMND23 Jan 2025
🚨Calling all experts, advocates, and those with lived experience! We’re looking for panel members to help develop Australia’s MND Care Guidelines. Help shape evidence-based Care recommendations nationwide. Interested? Express interest by Feb 16 to [email protected]
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Andrew Tosolini retweeted
Diana Piol@diqnqpi11 Dec 2024
🔬🧠 We're hiring!! Research associate opportunity @dsb_unipd @PennutoLab Deadline: *10th January 2025* #MotorNeuronDiseases #LocalTranslation #SpatialOmics
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