@EddaGSchulz

Systems Biology, Epigenetics, X-chromosome inactivation Lise-Meitner Research Group Leader @MPI_MolGen in Berlin, @eddaschulz.bsky.social

 Berlin, Deutschland
Joined August 2017
  • Tweets561
  • Following346
  • Followers1.6K
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📢 New preprint from the lab! CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated at the Xist locus. See his tweetorial below. biorxiv.org/cgi/content/shor…
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@LabSchirmer, @PlathLab @The_Lei_Team, Giacomo Cavalli lab @CNRS, @EddaGSchulz, @deWitlab, @MJordanRowley, @LabNamekawa, @PalancadeLab, Michael Levine lab @PrincetonMolBio, @MelikeLak, @daph_cabi, @jbrickner, Noriko Saitoh lab (The Cancer Inst Hospital of JFCR), @MustafaMir16
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PhD position available in my lab - Fully funded! Please, apply or RT! 👩‍🔬🐭🧫
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Together with PhD student @AlexandraMMar we wrote a News&Views @NatureGenet about the new paper📜 from @xielablife. A stunning data set on the 3D chromatin structure of the X chromosome in early embryos reveals unexpected large-scale structures: 🐭🧬🔺🔺nature.com/articles/s41588-0…

Structural remodeling of the inactive X chromosome during early mouse development

Nature Genetics - The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding...

nature.com
Wei Xie@xielablife11 Sep 2024
One of the X chromosomes in females is silenced with a microscopically distinct chromatin configuration. Happy to share our latest work on deciphering how the X chromosome folds during its inactivation for the first time in mouse female embryos! nature.com/articles/s41588-0…
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Our new work is out today! Long time in the oven, this has been a really fun and informative collaboration led by Dhanur Iyer in my lab and @HK_Heidar from @NRivron lab. We show that human embryonic cells have an inherent potential to regulate their developmental timing.
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Don't miss Daniela Cecalev @cecalev's review on "Compensation of gene dosage on the mammalian X" together with Beatriz Viçoso and myself, for a comprehensive look into X upregulation and inactivation! ⬆️⬇️ journals.biologists.com/dev/… With support from @FRM_officiel and @laliguecancer

Compensation of gene dosage on the mammalian X

Summary: This Review focuses on sex-chromosome dosage compensation in mammals, discussing classic and recent hypotheses, observations and mechanisms regarding X-chromosome upregulation and X-chromo...

journals.biologists.com
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Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Group at a participating Max Planck Institute of your choice - the next open topic call starts on Sep 9, 2024. Stay tuned for updates!🌟 mprg.mpg.de

Apply now!

The announcement for 2026 Max Planck Research Group Leader positions is open from 9th September until 14th October 2026.

mpg.de
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if you are passionate about the therapeutics of the future and want to be part of the 'RNA revolution' apply for this project in our lab: we want leverage the latest AI models for the prediction of potential small molecules targeting RNAs in the cell! t.ly/BjO5o

Deep learning for RNA-targeted drug discovery to predict RNA-small molecules interactions. AI is...

Deep learning for RNA-targeted drug discovery to predict RNA-small molecules interactions. AI is revolutionizing the field of drug discovery in the pharmaceutical industry by offering effective means...

linkedin.com
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Congratulations, Valerie!!
Hilgers Lab @hilgerslab.bsky.social@hilgers_lab2 Jul 2024
New job, starting next summer! Extremely excited to join the extraordinary scientific environment at @UniBasel and the @DepBiomedicine.
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Edda Schulz retweeted
Elena@Elena_babyyyy27 Jun 2024
📢 WE ARE HIRING! We offer a position as Research Technician in Stem Cell Biology to work in sex differences in neurodevelopmental disorders and human X chromosome inactivation. More info: werkenbijerasmusmc.nl/en/vac…
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on unimodal setpoints and how to get them from synthetic promoters... tweetorial coming soon... or see you next Thursday #SEED2024 in Atlanta... Stay tuned for more control systems coming soon...
bioRxiv Synthetic Biology@bioRxiv_synbio21 Jun 2024
Programmable promoter editing for precise control of transgene expression ift.tt/RchaKp6 #biorxiv_synbio
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It was a pleasure to write this review together with @nellykanata and Rachel Duffie @sneexish from the Lomvardas lab on the principles that govern monoallelic expression of olfactory receptors and Xist for @Dev_journal
Development@Dev_journal3 Jun 2024
Establishment and maintenance of random monoallelic expression In this Review, @nellykanata, @sneexish & @EddaGSchulz @MPI_MolGen give an overview of the regulatory mechanisms and current models for establishment and maintenance of monoallelic expression: journals.biologists.com/dev/…
figure 2: The establishment of monoallelic Xist expression.

ALT figure 2: The establishment of monoallelic Xist expression.

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Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.1101/… 1/17

A Scaffolding Element Rewires Local 3D Chromatin Architecture During Differentiation

Upon differentiation chromatin rewires to reflect its new cellular identity and function. While it is widely known that this process involves cooperative changes in transcription, chromatin composi...

biorxiv.org
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Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new @RSocPublishing biographical memoir: royalsocietypublishing.org/d…
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Climate experts were increasingly saying that keeping heating below 1.5C is near impossible, yet it remains the global goal. So I asked hundreds of top IPCC scientists what they thought. What they said shocked even me… 🧵 1/n #ClimateCrisis
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Edda Schulz retweeted
GBM e.V.@GBM_eV22 Apr 2024
📢Time to voice our concerns about the #WissZeitVG once again! ➡️17 scientific societies, which together represent more than 55,000 scientists, are speaking out! 👉Please share our initiative! 🔁Please RT
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🥼 Open PhD position! 🌞🌞We are recruiting new lab members in the beautiful Seville 🗣️Please RT! 👋Contact me if you are interested: [email protected]
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WRT the recent interest in TbxT, aka #Brachyury, & all kind of tails, nice historical perspective on this most iconic gene in the history of #DevBio shorturl.at/lEK57. Below, heroes of Brachyury (Fig.2 in ref ) + B. Herrmann, who cloned the gene &, of course, the T/+ mouse
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🔬🧬 Exciting PhD Opportunity! I am looking for a motivated PhD candidate with a strong profile in mammalian epigenetics and gene regulation to strengthen my team at SILS (University of Amsterdam). Application deadline March 21st For more details, tinyurl.com/hznwtjmb
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