@LabSchirmer

nuclear envelope, genome organisation, laminopathies,

 The University of Edinburgh
schirmer.bio.ed.ac.uk
Joined September 2021
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  • Following45
  • Followers40
How is the genome organized in fat tissue? Our new study on #genomeorganisation in #lipodystrophy is published today in @NatureComms. We show that Tmem120a gene knockout in fat leads to lipodystrophy in mice due to disrupting genome organisation in fat rdcu.be/cEUW1
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New paper: Enhancers on the edge - how the nuclear envelope controls gene regulatory elements @WTcell @mrc_hgu @EdinUni_IGC @RafalEstrella Read more here: doi.org/10.1016/j.gde.2024.1…
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Happy to share our newest review by Rafal Czapiewski @RafalEstrella In this work we discuss current research on the nuclear envelope control of the 3D genome and especially the regulation of the enhancers and other regulatory elements. sciencedirect.com/science/ar…
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Probably yet the most esthetic project of my entire career... Could I even imagine, some quarter of a century ago, doing my PhD on spiral waves in model chemical equations that I would be studying these intricate wave patterns in a real LIVING biological system!! Fascinating...
Journal of Cell Biology@JCellBiol23 Jun 2022
Ani Michaud, @GoryachevAndrew, George von Dassow, William Bement @BementLab, et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, and RGA-3/4. bit.ly/3O2fBfi #CellCycle #CellDivision #Cytokinesis #cytoskeleton
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We are hiring a postdoc @EdinburghUni #epigenetics #Edinburgh nature.com/naturecareers/job…
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We are back @EdinEpigenetics Seminars with @Hannah_K_Long @mrc_hgu @RafalEstrella @SBSatEd @crm_edinburgh
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Interested in nucleus size in cancer and how to target it with old drugs? Check the latest from @LabSchirmer published today! pubs.acs.org/doi/10.1021/acs…

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects...

Abstract. Background: Lower survival rates for many cancer types correlate with changes in nuclear size/scaling in a tumor-type/tissue-specific manner. Hyp

pubs.acs.org
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Check out our latest research on targeting cancer cell nucleus with old drugs! ed.ac.uk/biology/news-events…
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breaking news! Discovery could hold the key to alleviating metabolic disease eurekalert.org/news-releases…

Discovery could hold the key to alleviating metabolic disease

A newly characterized fat protein could provide the missing link to explain a rare metabolic disease while offering fresh insight into common disorders such as obesity and type 2 diabetes.

eurekalert.org
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5. We see genes are also spatially disorganized in #musculardystrophy.
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6. Finally, we see regulatory miRNAs also changed by genome organization disruption, arguing that injection of miRNAs could be used therapeutically and/ or simply used by athletes to gain muscle mass.
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When email from the editor starts with "We are delighted to..."
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#PostdocAppreciationWeek 🧑‍🔬🌟 @RafalEstrella from Eric Schirmer's lab studies rare diseases caused by mutations in genes coding for proteins of nuclear lamina with a focus on #lipodystrophy and #musculardystrophy ➡️ edin.ac/3lYCCCS #NPAW2021 @UK_NPAW
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Congratulations to Chalres Dixon from @LabSchirmer for his STING paper. Its online today: sciencedirect.com/science/ar…
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