Brandon, Manitoba
Joined January 2023
Dr. Jose Antonio, el gurú mundial de los suplementos nutricionales: "El café es una de las bebidas más saludables" Many thanks to all of the super-smart and fun men and women of the ISSN! We had an amazing time in Malaga, Spain. The food was amazing. We treated eating like an Olympic sport. Our team from L to R: Jose Antonio, Richard Kreider, Cassie Evans, Ralf Jager, Shawn Arent, Michelle Singleton, Scott Forbes, Katie Vasenina, Tony Ricci, Brandi Antonio, and Corey Peacock. Last but not least, thank you, Diego Bonilla, for bringing this event to life and making it happen. Oh, one last thing. Tony Ricci and I agree that the coffee was second to none! @ShawnArent @DrCreatine @DrCPeacock
1
6
839
How does muscle growth actually progress over time? Our new systematic review and meta-analysis, posted as a preprint (DOI:10.51224/SportRxiv.910), pooled 3,237 observations from 480 studies to model the trajectory of resistance training-induced muscle growth. As expected, muscle growth follows a curvilinear trajectory. Gains occur relatively rapidly during the early stages of training and then progressively slow as training continues. At 10 weeks, the model estimated an average increase in muscle size of approximately 7%. This increased to ~7.5% at 12 weeks, ~8.9% at 20 weeks, ~10.5% at 36 weeks, and ~12.6% at 78 weeks. In other words, hypertrophy displays diminishing returns—but diminishing returns do not mean no returns. Gains continue to accumulate; they simply become progressively smaller over time. Importantly, there was substantial variability around these averages. At 10 weeks, for example, the 95% prediction interval ranged from approximately −7% to +22%, highlighting just how much hypertrophic responses can differ across studies and individuals. Moreover, most of the included studies were relatively short in duration, limiting our ability to draw conclusions about the rate of hypertrophy over longer training periods (above ~16 weeks). Perhaps more importantly, research studies are generally designed to determine group-level effects rather than to optimize muscle development for each individual. Thus, these findings provide a useful framework for understanding the general trajectory of hypertrophy over time, but should not be interpreted as defining the limits of what a person can achieve with a customized, well-designed training program. Take-home: Muscle growth tends to occur most rapidly during the early stages of resistance training, with the rate of gain progressively slowing as training exposure accumulates. However, diminishing returns do not mean an end to progress, and early rates of growth should not be extrapolated linearly over the long term. Shout out to @BM_Roberts_SkM for spearheading the project 💪 sportrxiv.org/index.php/serv…
15
83
4
487
26,947
🤖 Made with AI
Join us in Medellin Colombia for ISSN-Latin America! Nov 13-16! motioncolombia.com/landing-2…
1
2
9
1,307
In our latest review, we focus on the application of creatine supplementation for mitigating 🧠 metabolic stress #creatine @NTFabiano @DrCreatine academia.edu/3071-4087/2/2/1…
2
14
2
56
6,340
Scott Forbes retweeted
🚨NUEVO: La suplementación con creatina no se relaciona con incremento en los efectos secundarios. 👉🏽Es totalmente segura en un rango de dosis, duraciones y poblaciones, según los ensayos en humanos disponibles a la fecha😎: mdpi.com/2075-4663/14/4/137
3
8
37
2,130
A single dose of creatine reduces the cognitive effects of sleep deprivation.
111
433
81
5,397
678,281
Scott Forbes retweeted
Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes @JoseAntonioPhD @darrencandow @DrCreatine @_MCRicardo_ cureus.com/articles/471288-e…
4
1
6
897
Scott Forbes retweeted
Pleased to publish a 25y update to my 2001 review: Anaerobic and Aerobic Energy System Contribution During Maximal Exercise (Sports Med) Synthesising 102 studies of energy system interplay during maximal efforts 🔗 rdcu.be/fcXUu #ExercisePhysiology @hareshsuppiah
5
87
8
393
49,551
#CreatineForHealth Lack of sleep adversely affects cognitive function, motor skills, and mood, partly because of reduced creatine levels in the brain. Hence, it has been posited that CrM could alleviate these detrimental effects of sleep deprivation. #CreatineMonohydrate
1
2
5
448
This is one of the most common misunderstandings I see: Creatine starts → creatinine rises → kidney panic But sometimes the biomarker changed more than the kidney did. That is why isolated creatinine can mislead. Full breakdown + free review: substack.com/home/post/p-192…
1
3
446
When combined with 16 weeks of high-repetition resistance-band training, 3 and 5 grams of creatine/day (without a loading phase) improves some measures of body composition and strength in untrained healthy adults (≥ 50 years of age). sciencedirect.com/science/ar…
7
17
907
Scott Forbes retweeted
Creatine supplementation for performance & recovery 💪 This new review examined how creatine supplementation impacts… ⚡️ High-intensity performance 🔁 Recovery & muscle damage 🏃 Endurance & intermittent sport performance 🧠 Cognitive function & resilience …across athletic, endurance, team sport, and tactical populations 📚 Here are the key findings ⬇️ Energy production & ATP resynthesis 🔋 👉 Creatine increases phosphocreatine stores, allowing faster ATP regeneration during high-intensity efforts Strength & power performance 🏋️ 👉 Consistently improves strength, power output, and training capacity, especially in repeated high-intensity efforts 👉 Strength gains of ~8% greater than training alone have been reported in some studies Repeated sprint & team sport performance ⚽️ 👉 Enhances repeated sprint ability, agility, and fatigue resistance 👉 Particularly relevant for sports with intermittent high-intensity demands like football and rugby Training adaptations & muscle mass 📈 👉 Supports greater training volume over time → leading to increases in lean mass and hypertrophy 👉 Long-term use linked with meaningful increases in muscle fibre size and total body mass Recovery from muscle damage 🔁 👉 May accelerate strength recovery in the days after intense or eccentric exercise 👉 Can reduce markers of muscle damage, inflammation, and oxidative stress (though findings vary) Endurance performance 🏃 👉 No consistent benefit for steady-state endurance performance 👉 BUT improves high-intensity surges, finishing sprints, and interval capacity within endurance events 👉 May support glycogen resynthesis when combined with carbohydrate intake Thermoregulation & hydration 🌡️ 👉 Increases total body water and intracellular fluid 👉 May help maintain plasma volume and improve heat tolerance in demanding environments Cognitive function & neuroprotection 🧠 👉 May support attention, memory, and decision-making 👉 Can attenuate cognitive fatigue during sleep deprivation or stress 👉 Potential neuroprotective role in high-impact or contact sports Inflammation & immune support 🛡️ 👉 May reduce pro-inflammatory cytokines and oxidative stress following intense exercise 👉 Potential role in supporting gut integrity under high training loads Typical dosing 💊 👉 Loading: ~20 g/day for 5–7 days (optional) 👉 Maintenance: ~3–5 g/day 👉 Or ~3 g/day for ~4 weeks to fully saturate stores without loading Body mass considerations ⚖️ 👉 Small increases in body mass (~0.5–1 kg) are common 👉 Can be beneficial for strength/power athletes but may impact running economy in some endurance contexts Reference: pubmed.ncbi.nlm.nih.gov/4187… Subscribe to Performance Nutrition Digest FREE to receive your daily study breakdown, straight to your inbox or via the Substack app 📥 performancenutritiondigest.c… Performance Nutrition Digest is powered by Healthspan Elite⚡️ healthspanelite.co.uk/
9
1
33
1,548