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THE GLP-1 MUSCLE PARADOX
Let’s have an intellectually honest conversation about GLP-1s and muscle loss.
The SURMOUNT-1 DXA substudy evaluated body composition changes in patients taking tirzepatide.
The smallpox, polio, and MMR vaccines didn't eradicate iron lungs and severe pediatric disability by being 'poison.' Dismissing a century of medical progress with a sweeping headline might get (zero) likes online, but it has zero grounding in reality or physiology.
We did NOT elect you for BS like this!
@POTUS
All vaccines are poison!
whitehouse.gov/presidential-…
Larry being Larry. He doesn’t let facts change the outlook that pays his bills, provides his interactions, or whatever his goal is in spreading falsehoods.
The vaccine was so dangerous, so ineffective, so disgusting, that parents would rather go to jail - and did - than allow their children to go through a filthy smallpox vaccination process. Tens of thousands of people protested against this barbaric process of cutting into an infant’s skin and rubbing diseased pox into the wound only to watch these children die or be permanently injured from the process. The anti vaccine movement began with this disgusting and filthy process that was mandated across countries. Doctors of the time testified that the smallpox vaccine didn’t work and was barbaric. Stop romanticizing the death and destruction caused by a horrific pox infection process that killed countless children Neil.
Readers added context they thought people might want to know
The smallpox vaccine used vaccinia (cowpox) virus, not material from smallpox lesions. It proved highly effective: the WHO confirmed global eradication of smallpox in 1980, with the last natural case occurring in 1977. web.archive.org/web/2026080504… who.int/emergencies/si…
A coronary calcium score of 0 is genuinely reassuring. It usually signals lower near-term cardiovascular risk.
But it does not mean “clean arteries,” zero plaque, zero future risk, or permission to ignore the rest of the risk profile.
Think of CAC 0 as a favorable snapshot, not a lifetime warranty.
The goal is to preserve that low-risk state: avoid tobacco, control blood pressure and atherogenic lipoproteins, exercise, and support metabolic health.
A zero should lower fear, not eliminate attention.
Full article and references:
propstmetabolichealth.substa…
#CardiovascularHealth #CoronaryCalcium
I’m calling BS on this.
Anyone who says “I have xxx friends who tell me xxx” is lying.
MASLD and MASH are not letters in the formal CKM acronym, but the liver belongs in the conversation. Obesity, insulin resistance, diabetes, kidney disease, cardiovascular disease, and metabolic liver disease share overlapping drivers. Treat the whole patient.
1/9 Muscle ultrasound can add useful information to a muscle evaluation.
But it is not a complete muscle-health test.
Here is what it measures, where it may help, and where the limits remain. 🧵
8/9 Routine B-mode ultrasound and raw echo intensity should not be treated as direct quantitative measurements of intramuscular fat.
A bright image may carry information under controlled conditions, but it is not a tissue assay.
9/9 Best current framing:
Ultrasound adds one local structural layer to a muscle evaluation. It does not replace strength testing, physical performance, or clinical judgment.
Full review: open.substack.com/pub/propst…









