@DikicLab

Research group of @iDikic2 at @IBC2_GU. ubiquitination, autophagy, host-pathogen interactions

 Frankfurt, Germany
biochem2.com/research-group/molecular-signaling
Joined August 2020
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  • Following79
  • Followers1.2K
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🎙️Honored to enjoy insightful presentations on “RNA-based therapeutics” & “New targets & therapeutic approaches” on day 2 of the 1st Symposium on Advances in Therapeutic Approaches.🙏Thanks to all speakers & participants for their valuable contributions. @BMBF_Bund @HMWK_Hessen
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We are making a move ➡️🦋 Follow us there: bsky.app/profile/dikiclab.bs…
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🤩It's out! Check out our latest paper describing an optimised #CRBN that we used for high-throughput drug screening and developing new chemo-proteomic assays. #HTS #TPD @proxidrugs @IBC2_GU @goetheuni
Cell Chemical Biology@CellChemBiol
27 Nov 2024
Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by Henry Bailey, Jonathan Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 @DikicLab et al at @goetheuni @IBC2_GU @MPIBP @merckgroup dlvr.it/TGRCyX
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*See, share, register* for the Frankfurt Conference on Quality Control in Life Processes, 24-27th of March. The speaker's lineup looks amazing already!! 🤩 👉Registration before 1st of December: fcqc.de #FCQC2025 #autophagy #proteostasis #ubiquitin
SFB 1177@sfb1177
26 Nov 2024
Excited to announce the keynote speakers at #FCQC2025! Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech Stay tuned for more updates and don't forget to register!  fcqc.de/ #autophagy #ubiquitin #TPD #UPS #signaling
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SFB 1177@sfb1177
26 Nov 2024
Excited to announce the keynote speakers at #FCQC2025! Aaron Ciechanover from @TechnionLive and @dixitvishva from @genentech Stay tuned for more updates and don't forget to register!  fcqc.de/ #autophagy #ubiquitin #TPD #UPS #signaling
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SFB 1177@sfb1177
21 Nov 2024
🔔 Registration deadline approaching! Don't miss out and secure your spot now! 🔗 fcqc.de/ #FCQC2025
SFB 1177@sfb1177
3 Sep 2024
#FCQC2025: Registration open fcqc.de/ Join us for a high-caliber line-up of talks on quality control mechanisms & networks, the interplay of autophagy & ubiquitin in health & disease, novel therapeutics using the ubiquitin system. #proteostasis #autophagy
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The 2024 #Proxidrugs annual retreat was once again a great chance to meet our colleagues from the consortium. A big shout out to our team members who represented us on stage @acjacomin @GiulioGiulian16 Henry Bailey @mohitasya @shahvarun28 #Cluster4Future @proxidrugs @IBC2_GU
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7th year in a row that Ivan is on the @Clarivate Highly Cited Researchers list. Congratulations @iDikic2 , and a big thank you to all the team members, past & current collaborators and colleagues. #HighlyCited2024 @ClarivateAG @goetheuni @IBC2_GU
IBC2@IBC2_GU
19 Nov 2024
🥳 Proud to see IBC2 Director @iDikic2 on the #HighlyCited2024 list for the 7th year in a row! Congratulations to all @goetheuni colleagues on the list - @StefanieDimmel1, @HummerLab, Florian Greten, Sibylle Loibl & Stefan Offermanns
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How changes in kinetics of #splicing can lead to proteotoxic cell death & what is the role of #ubiquitination and ER-phagy in this process? Congrats to Cristian & all collaborators for this fascinating discovery 👏 More info: nitter.cf/IBC2_GU/status/1857149… science.org/doi/10.1126/scie…
Cristian Prieto-Garcia@CristianPG_mlg
14 Nov 2024
It is finally out! My first @ScienceMagazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor @iDikic2 for all the support and trust ! 🫶. Science science.org/doi/10.1126/scie…

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular...

science.org
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Excited to share our latest research published in @ScienceMagazine! Cryptic splicing can lead to proteotoxic stress, but how do cells cope? Our study uncovers the role of ubiquitination and ER-phagy in mitigating the effects of misfolded proteins. science.org/doi/10.1126/scie…
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We’re incredibly proud of this work and grateful to the amazing team behind it.🙌@IBC2_GU @goetheuni @CristianPG_mlg @iDikic2 @mixmue @BrandesLab @JamesAOo7 @StainierLab @shahvarun28 @GiulioGiulian16 @acjacomin @WojtekGalej @ManuelKaulich @IEbersberger @ronaycetin @RayeneBerkane
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@MPIbp @imbmainz @srcsb @mpi_hlr @KyushuUniv_EN @UCAS1978 @SFB1531 @EnableFrankfurt @dzhk_germany @proxidrugs @ProLOEWE @trr267 @BMBF_Bund @Fraunhofer
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I am very happy to have had the opportunity to present our latest results on targeting #legionella with #protacs. Especially in a session with such renowned scientists. Thanks to Antje Flieger and her team at @rki_de for organising this meeting.
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We can’t wait for this conference!😍4 days to talk about quality control mechanisms, the interplay between #autophagy and #ubiquitin and emerging therapeutics utilising the ub system. Registration Deadline: 1st Dec fcqc.de #FCQC2025 @goetheuni
Women in Autophagy@WAutophagy
8 Nov 2024
SAVE DATE: March 24-27, 2025, in Frankfurt. "4th Frankfurt Conference on Quality Control in Life Processes". FCQC.de
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Really happy to take part of this amazing manuscript from @crypt_tales and @DiefenbacherL published in @oncogenejournal . USP10 promotes colorectal cancer and stemness. #ubiquitin #cancerResearch 🫶👏🏻
Michaela Reissland@crypt_tales
4 Nov 2024
🥳I am beyond to finally share the story of my PhD out now: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer nature.com/articles/s41388-0… Lets have a little look what we found: 🧵1/11

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Oncogene - USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

nature.com
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I’m thrilled to share that my latest research paper has been published in PNAS! 📄 pnas.org/doi/10.1073/pnas.24… A big thank you to all the co-authors 🙏 @RamBhaskara4 @KateLohachova @iDikic2 @HummerLab. Thanks to @IBC2_GU @BMLS @EnableFrankfurt @sfb1177 @dfg_public
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Really happy to contribute with mouse liver cancer models and human cancer data analyses to this amazing Cell paper from @iDikic2 and Herhaus lab. Huge congrats to Lina, Uxia, Ivan and other authors from @jwadeharperlab , @ManciasLab, @DikicLab, etc.👏🏻 sciencedirect.com/science/ar…
Cell@CellCellPress
30 Oct 2024
Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

IRGQ acts in the quality control of MHC class I molecules through autophagy, mediating tumor immune evasion.

cell.com
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Dikic lab retweeted
Cell@CellCellPress
30 Oct 2024
Now online! IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion dlvr.it/TFvLRM

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

IRGQ acts in the quality control of MHC class I molecules through autophagy, mediating tumor immune evasion.

cell.com
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🥳Excited to share our latest research on the role of the autophagy-lysosome system in tumour progression! #cancer #immunotherapy #autophagy @FCI_health @EnableFrankfurt @IBC2_GU @goetheuni sciencedirect.com/science/ar…
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We identified IRGQ as a key regulator of MHC-I quality control. Its absence enhances CD8+ T cell responses. Reduced IRGQ levels in hepatocellular carcinoma patients and mouse models lead to improved survival by promoting anti-tumour immunity. #CancerResearch #Immunotherapy
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And, of course, a huge thank you to all our collaborators and funders 🫶 @IBC2_GU @EnableFrankfurt @sfb1177
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