@ManciasLab

#PancreaticCancer Research Lab interested in selective #autophagy, iron, therapeutic resistance, and #proteomics. @DanaFarber, @BrighamWomens, @harvardmed

Boston, MA
Joined May 2017
Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors: nature.com/articles/s41467-0…
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How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/ar…
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During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: bit.ly/47G1kQ9 @EileenMOReilly @ManciasLab
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Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research. #AACRpan24 @ManciasLab
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#AACRpan23 @graceah9 presenting her poster today - an awesome collaboration with @ManciasLab
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WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word. au.dk/om/stillinger/job/post… lnkd.in/eNgDM74z
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Our #OpenAccess review on #PancreaticCancer - advances & challenges is now online at @CellCellPress Many thanks to @CJHPhD @Pasca_Lab & @LyssiotisLab for all the hard work & @jiaying_tan6 for the opportunity. It’s FREE to read so share widely! cell.com/cell/fulltext/S0092…
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A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target: bit.ly/3uQwFgd
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Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR aacrjournals.org/cancerres/a…
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Now online in @CD_AACR: Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition by Vaibhav Jain, David Speicher, @AmaravadiRavi and colleagues @TheWistar @PennCancer aacrjournals.org/cancerdisco…
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Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer. forbes.com/video/63128816421…
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On the cover!! Thanks @CD_AACR for featuring work from our lab by Miru Ravichandran and @ManciasLab @SantanaCodina on the cover !
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Thanks to @CD_AACR for featuring our stories @ManciasLab and @rushika_perera on the cover of the September issue!
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🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.
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Happy to share our latest work now out in @nature. At long last, we resolved the structure of the SHOC2-RAS-PP1C complex and integrated this work with deep mutational scanning to comprehensively evaluate #SHOC2 structure and function. 🧵(1/n) nature.com/articles/s41586-0…
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