@HummerLab

Molecular simulations and computational biophysics @MPIbp

 Frankfurt, Germany
biophys.mpg.de/theoretical-biophysics
Joined June 2021
  • Tweets64
  • Following72
  • Followers2.5K
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Hummer Lab retweeted
IBC2@IBC2_GU
28 Oct 2024
A multidisciplinary team around @RamBhaskara4 from @IBC2_GU @goetheuni provides fresh insights into the role of intrinsic disorder in large-scale membrane shaping during ER-phagy. @HummerLab @DikicLab @EnableFrankfurt @sfb1177 @SCALE_Uni_FFM
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Hummer Lab retweeted
Di Wu@MiChAeL_900922
22 May 2024
Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: nature.com/articles/s41586-0… Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪

Molecular mechanism of choline and ethanolamine transport in humans

Nature - Structural analysis of the human choline and ethanolamine transporters FLVCR1 and FLVCR2 clarifies the mechanisms of transport, the conformational dynamics of these proteins and the...

nature.com
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We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: nature.com/articles/s41467-0… See it in action in our short video!
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Congratulations!!!👏😀
Sergio Cruz-León@SergioCruzLeon1
13 May 2024
We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: nature.com/articles/s41467-0… See it in action in our short video!
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In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).
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Our team’s latest research on IDRs in membrane remodeling. #membraneremodeling #ERphagy @HummerLab @DikicLab
bioRxiv@biorxivpreprint
29 Mar 2024
Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy biorxiv.org/cgi/content/shor… #bioRxiv
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Heartfelt congrats to our group leader @eugene_kim__ (@EKimlab) on receiving the Heinz Maier-Leibnitz Prize, one of the most important awards for early-career researchers, for her research on genome packaging! #biophysics @dfg_public @maxplanckpress 👉 biophys.mpg.de/eugene-kim-he…
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#ATP, the energy currency of cells, is produced by the mitochondrial protein ATP synthase. Our @HummerLab provides new insights into the structural mechanism and energetics of the crucial proton-driven c-ring rotation by atomistic free energy calculations👉pnas.org/doi/10.1073/pnas.23…
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a true adventure and privilege to work Danny's team and colleagues (cryoEM, MS, SAXS) @IBCSinica @asibc512 @AcadSinica @khooAS @TzuJingYang @SKCM2_HU @KarenMinfenghsu big MD from @HummerLab @_mischi @SoBuelow enhanced sampling from @Isa_Grothaus @hmi_group and amazing @vidseh
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🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: pnas.org/doi/10.1073/pnas.23… @PNASNews

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated...

Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the archetypal member of the penta-EF hand protein family. ALG-2...

pnas.org
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Video by S. Rao: All-atom molecular dynamics simulation of the membrane-recruited ATG12-ATG5-ATG16L1-WIPI2 complex loaded with the ATG3-LC3 conjugate. Congratulations to all authors from @LazarouLab, @TheHurleyLab and @HummerLab on this amazing publication in @ScienceAdvances!
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S.Rao from our @HummerLab & coworkers resolve mechanism of LC3 delivery to the phagophore membrane, a key step in selective #autophagy, by combining #MDsimulations & experiments. Three-step targeting of ATG12-ATG5-ATG16L1 machinery leads to LC3 lipidation👉science.org/doi/10.1126/scia…
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Scientists from the MPI of Molecular Physiology (@mpimoph) and from our Department of Theoretical #Biophysics (@HummerLab) have identifed a region in actin that functions as a “molecular backdoor” for phosphate to exit through! 👉 biophys.mpg.de/2768357/throu…
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Very excited that our manuscript is now online @NatureSMB! nature.com/articles/s41594-0… We show how actin filaments release inorganic phosphate (Pi) through a “molecular backdoor” and demonstrate that the backdoor is distorted in a disease-linked actin variant. A thread (1/17)
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New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!
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The 2024 Gordon Conference on Autophagy will be held at the beautiful Il Ciocco site in Tuscany Mar. 10-15. If you have a passion for autophagy or just want to learn more, apply now before it gets oversubscribed! tinyurl.com/mu9dmc6w
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Detection of various complexes in cryo electron tomograms. Great work by @SergioCruzLeon1 and others now online. @MPIbp #teamtomo #cryoem @ChanZuckerberg
Sergio Cruz-León@SergioCruzLeon1
6 Sep 2023
🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.09.05.5…
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The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉biophys.mpg.de/cyddc #biophysics #cryoEM
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So nice to see Gerhard @HummerLab in Okazaki!
Ryota IINO 飯野亮太
@ryotaiino
29 Aug 2023
Prof. Gerhard Hummer (Max Planck Institute of Biophysics @MPIbp) gave a seminar at the 970th IMS colloquium and visited our lab with Kei-ichi @okapik! Thank you very much for great and thought-provoking seminar and discussion! biophys.mpg.de/theoretical-b… ims.ac.jp/en/research/semina…
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Hummer Lab retweeted
mito911@mito911_
19 Jul 2023
New @biorxivpreprint by Shanlin Rao @HummerLab and co-authors from @TheHurleyLab @LazarouLab for the collaborative work elucidating the mechansisms of LC3 targeting to membranes by the autophagy machinery @ASAP_Research @MichaelJFoxOrg biorxiv.org/content/10.1101/…

Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore

The covalent attachment of ubiquitin-like LC3 proteins prepares the autophagic membrane for cargo recruitment. We resolve key steps in LC3 lipidation by combining molecular dynamics simulations and...

biorxiv.org
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