Dan_Turner (@DanTurnez) profile picture

Dan_Turner

@DanTurnez

CSO at #Enhanc3dgenomics

 Cambridge, England
Joined August 2016
  • Tweets77
  • Following40
  • Followers390
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Photo by Dan_Turner (@DanTurnez)Photo by Dan_Turner (@DanTurnez)Photo by Dan_Turner (@DanTurnez)Photo by Dan_Turner (@DanTurnez)Photo by Dan_Turner (@DanTurnez)
I’m absolutely delighted to be starting my new job today as CSO at #Enhanc3dGenomics! I’ll be working with the amazing team here to unlock new therapeutic targets by looking at 3D genomic architecture. If you’re attending #AGBT24 please come to my talk on Thursday to hear more!
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I'm so delighted to see this Borg paper out as a preprint! @BanfieldLab and @MSchoelmerich are amazing collaborators and we're excited to be a part of it! @LynnLynnLynnLy @bowerlauwer @sfhickey1 et al.
Oxford Nanopore (@nanopore) profile pictureOxford Nanopore
@nanopore2 Aug 2023
Here @BanfieldLab used #nanopore sequencing to study 'the nature and existence of enigmatic genetic elements' (Borgs) in soil. They assembled 7 new curated Borg genomes, revealing extensive DNA methylation that differentiates them from their host archaea, Methanoperedens. 🧵1/2
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Phased nanopore assembly with Shasta and modular graph phasing with GFAse biorxiv.org/cgi/content/shor… #bioRxiv
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Awesome work from @timp0 looking at 5-hmC directly in brain gDNA using @nanopore #AGbt2023
Image from Dan_Turner (@DanTurnez)
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And if that’s not enough, protein-binding quantification!
Image from Dan_Turner (@DanTurnez)
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Pleased to release two new #NanoporeAppsTeam HMW DNA extraction protocols for @nanopore, from human brain and dry blood spots. Details here: community.nanoporetech.com/p…
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Join our #NanoporeAppsTeam Benchmarking Team to: ➡️ produce cutting edge, precise and up-to-date measures of our performance comparing to gold standards ➡️ convert our platform specs into metrics that are meaningful for @nanopore applications
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The #NanoporeAppsTeam are excited to release Reduced Representation Methylation Sequencing (RRMS) to uncover changes in methylation patterns associated with changes in gene expression and diseases such as cancer: bit.ly/3yL6kD9 (Community login required) 1/7
Image from Oxford Nanopore (@nanopore)
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I’m beyond excited that we, #NanoporeAppsTeam, can share RRMS with everyone. It utilizes two unique Nanopore features: ➡️ Adaptive Sampling ➡️ Native, highly accurate, per read, methylation calling 1/5
Oxford Nanopore (@nanopore) profile pictureOxford Nanopore
@nanopore6 Jul 2022
The #NanoporeAppsTeam are excited to release Reduced Representation Methylation Sequencing (RRMS) to uncover changes in methylation patterns associated with changes in gene expression and diseases such as cancer: bit.ly/3yL6kD9 (Community login required) 1/7
Image from Oxford Nanopore (@nanopore)
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S05.2: Complex rearrangement junction only resolved by using Nanopore reads! 👇#ESHG2022 #nanopore
Image from Rocío Esteban - ONT (@bio_rococo)
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This fantastic collaboration not only has groundbreaking biology, it has been the basis of our released @nanopore seq protocol for @10xGenomics libraries including bead clean-ups for full length transcripts and now also the sockeye analysis tool (no short reads) #nanoporeAppsTeam
Dan Landau (@landau_lab) profile pictureDan Landau@landau_lab10 Jun 2022
✂️🧬GoT-Splice! 🧬✂️ Excited to share new work connecting somatic mosaicism & MDS genotypes to splicing phenotypes in human samples! Led by the brilliant @fgaiti Paulina Chamely @allyhawkins92 & @alt_spliced team biorxiv.org/content/10.1101/…
Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human...

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human...

RNA splicing factors are recurrently affected by alteration-of-function mutations in clonal blood disorders, highlighting the importance of splicing regulation in hematopoiesis. However, our unders...

biorxiv.org
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.@shrutiiyer90 showing ultra-long sequence capture on @nanopore using #ACME. Spanning BRCA2 in single reads and looking at SVs in heterogeneous cancers #AGBT22
Image from Dan_Turner (@DanTurnez)
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Exciting to see our work on Pore-C out in @NatureBiotech. A new tool to add in the toolbox to understand the complex and fascinating nature of 3D chromatin conformation. Shoutout to @skimomiks @eoghh @Sisseljuul and all the collaborators! nature.com/articles/s41587-0…
Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer...

Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer...

Nature Biotechnology - High-order chromatin contacts are identified using a combination of 3C, nanopore sequencing and robust statistical analysis.

nature.com
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So excited to finally see Pore-C out in the wild. Great collaboration with @skimomiks @draditya12 and of course our very own @eoghh @DanTurnez . Protocol is on @nanopore website #ONT_Applications nature.com/articles/s41587-0…
Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer...

Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer...

Nature Biotechnology - High-order chromatin contacts are identified using a combination of 3C, nanopore sequencing and robust statistical analysis.

nature.com
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Interested in full-length, single-cell transcriptomics? Check out our ⁦@nanopore⁩ analysis pipeline #sockeye from ⁦@bowerlauwer⁩ github.com/nanoporetech/sock…
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Dan_Turner retweeted
Andrew Beggs (@adbeggs) profile picture
Andrew Beggs@adbeggs21 Dec 2020
So it’ll probably get lost in all the noise today on Twitter, but here is our preprint on more than *24,000* samples analysed by @nanopore LamPORE technology - both symptomatic and a symptomatic patients - finding > 99.5% sens and spec - medrxiv.org/content/10.1101/… – at Leamington Spa, England
Image from Andrew Beggs (@adbeggs)
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Oxford Nanopore’s LamPORE test for the detection of the #SARSCoV2 virus (for #COVID19) now CE marked for in vitro diagnostic use on the GridION device. Read more: bit.ly/2GVkYiz
Image from Oxford Nanopore (@nanopore)
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Dan_Turner retweeted
Andrew Beggs (@adbeggs) profile picture
Andrew Beggs@adbeggs25 Sep 2020
Replying to @nanopore
We’ve done it on *one* Gridion X5
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Scientists from @UniofOxford, @OUHospitals, @PHE_uk, @sheffielduni & @sheffieldhosp have published their evaluation of LamPORE in more than 500 clinical samples, showing 99.1% sensitivity and 99.6% specificity: bit.ly/3088OKh
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External evaluation of our @nanopore LamPORE test for #COVID19 Dx. Sensitivity: 99.1 % & specificity: 99.6 % medrxiv.org/content/10.1101/…
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