We study double-stranded RNA (dsRNA)--its biological functions and the proteins that bind it to mediate these functions. Views are our own!

Joined February 2019
Very excited for our new paper, now out in @CellCellPress! /🧵The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms of Tau transmission are not clear. /1
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Congratulations Esther!!
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Developed by @UofUBiochem scientists, a new kind of CRISPR that destroys cells rather than gene editing them has shown potential for killing sick cells while leaving healthy cells untouched. The technology could treat viral infections and cancer. attheu.utah.edu/health-medic…
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Bass Lab retweeted
"This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board." —@_david_ho_ nature.com/immersive/d41586-…
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Dr. Jennifer Lippincott-Schwartz (@HHMIJanelia) will be giving Thursday's Biochemistry Seminar on "Imaging Protein Synthesis at Micron and Atomic Scales"! 12pm in HSEB Alumni Hall.
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I don’t know what kind of NIH Director @DrJBhattacharya will be, and like many scientists I have concerns about aspects of MAHA. But there is a lot to like in the agenda he set out, and I hope people at least give him a chance.
Dr. Jay Bhattacharya just pledged to support dissident scientists in his Senate confirmation hearing: “Dissent is the very essence of science.” “23% of Americans have not much or no confidence at all … in scientists to act in the public’s best interests.” “I have five concrete goals if confirmed as Director of the NIH.” “First, NIH research should focus on research that solves the American chronic disease crisis.” “Life expectancy flatlined between 2012 and 2019, plummeted during the pandemic, and still has not bounced back.” “The chronic disease crisis is severe, with hundreds of millions of Americans—children and adults—suffering from obesity, heart disease, cancer and more.” “Second, NIH-supported science should be replicable, reproducible, and generalizable.” “Unfortunately, much bought modern biomedical science fails this basic test.” “Third, if confirmed, I will establish a culture of respect for free speech in science and scientific dissent at the NIH.” “Over the last few years, top NIH officials oversaw a culture of cover-up, obfuscation, and a lack of tolerance for ideas that differ from theirs.” “Fourth, the NIH must recommit to its mission to fund the most innovative biomedical research agenda possible to improve American health.” “Fifth, the NIH must embrace, and vigorously regulate, risky research that has the possibility of causing a pandemic.” “If confirmed, I'll carry out President Trump's agenda of making the public science institutions of this country worthy of trust and serve to Make America Healthy Again.” @DrJBhattacharya
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On Thursday Feb 20th, Dr. Samuel Hobbs @DanaFarber will give a Biochemistry seminar entitled "Mechanisms of viral immune evasion conserved across the tree of life." HSEB 1730 at 12pm!
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Looking forward to this symposium next month, including Erica Hastings from my lab @UofUBiochem
Watch for the Utah CIHD U54 Rising Stars in Iron, Heme and Hematology Symposium March 10th, 2025! @NIDDKgov
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Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/4gtYosR
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In response to the federal directive issued on Feb. 7, 2025 to change the Facilities and Administration rate for all existing and ongoing new @NIH research awards, UW–Madison has issued the following statement. news.wisc.edu/uw-madison-res…
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Confirmed: DOGE operatives attempted to gain access to secure spaces, sources tell me and @lbarronlopez . This as a group of Democratic senators is raising alarm and asking for precise information on what happened. foreign.senate.gov/imo/media…
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Bass Lab retweeted
The Trump administration is continuing to dismantle USAID, placing almost all personnel on administrative leave globally. A post on the agency's website claims that travel back to the U.S. for staff stationed in other countries will be arranged. For more, @IAmAmnaNawaz speaks to Andrew Natsios, the administrator for USAID during the George W. Bush administration.
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Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇
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Don’t miss out on this seminar featuring our very own Dr Thomas Koch!
Join us on 9 October at 5pm CET for a new EUVEN seminar featuring Thomas Koch discussing cone snail venom evolution, and Schyler Ellsworh discussing mechanisms of venom resistance in flies. Register at bit.ly/3EUvDVe @Schy_Ellsworth @LundKoch
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Bass Lab retweeted
Think Mass Spec can't do RNA-seq & RNA modification mapping? Think again! With the trick of generating RNA ladder (the very core of Sanger sequencing) our work with @sz2110 enables De Novo RNA-seq & mapping of multiple RNA modifications in #tRNA @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.1101/…
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Bass Lab retweeted
1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn
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The first review written entirely by the Cottrell Lab is now available here doi.org/10.1042/BST20230727. Hopefully, it will be a worthwhile read for those interested in dsRNA sensing in cancer. @PPPublishing @PurdueBiochem @PUCancerInst
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