Laboratory of organelle biogenesis and homeostasis - studying ER organization and size control; discovering roles for the nuclear envelope lipid environment

Yale Science Building
Joined March 2014
Congratulations to David Breslow of Yale University, recipient of the 2026 ASCB Innovation in Research Award recognizing groundbreaking research in cell biology. ascb.org/society-news/ascb-a…
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Out today in @JCellBiol Work from the Mogessie, @FachinettiLab & @DrSteffi labs reveals how CENP-A/B/C cooperate to maintain kinetochore function in oocytes and how declining centromere strength predisposes aging eggs to aneuploidy. @pewhealth @HFSP doi.org/10.1083/jcb.20260613…
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How does aging drive #oocyte #aneuploidy? Work from Mogessie, Fachinetti, and Redemann labs links reduced CENP-A/CENP-C to high rates of chromosome segregation errors during maternal #aging. hubs.la/Q04BzWpd0 #Development #Cytoskeleton #Genetics #Celldivision
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Bahmanyar lab retweeted
Excited to share my postdoctoral work from the @BahmanyarLab! doi.org/10.64898/2026.02.27.… We show that preferential tethering by LEMD2 over Emerin ensures faithful nuclear envelope assembly and link PC homeostasis (via CTDNEP1/CNEP-1) to nuclear morphology.
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Bahmanyar lab retweeted
Super proud of my lab mate @vicpuccini from the @Bahmanyarlab for successfully defending her thesis today! 🎉 She discovered that the new transmembrane nucleoporin NPP-28/TMEM209 controls PLK-1 localization in mitosis. Check out our preprint here: biorxiv.org/content/10.64898…
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great article by Izzy Backman about our recent and ongoing work! Yale Tool Links Molecule Clusters to Neurodevelopmental Disorders m.yale.edu/dmtp
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Excited and grateful to be chosen as the 2026 ASCB Innovation in Research Award recipient! I especially want to thank all lab members, whose research is recognized here. Congrats as well to the other ASCB honorees.
Congratulations to the 2026 ASCB Honorific Award Winners! This year's recipients are recognized for outstanding achievements in research, education, mentoring, leadership, and inclusion that continue to advance cell biology. See the full list: ascb.org/society-news/ascb-a…
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Bahmanyar lab retweeted
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7) cell.com/cell/fulltext/S0092…
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Bahmanyar lab retweeted
James Olzmann (@OlzmannLab at @UCBerkeley) won the 2026 Avanti Award in Lipids. His work has advanced knowledge of lipid droplets, lipid metabolism & ferroptosis. ⏯️Watch his #ASBMB26 talk, "Guardians of the membrane": youtu.be/QJ5YOsUCuHQ #LipidResearch @AvantiResearch
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Visibility in Academia, like in the world, is not fixed; it is produced. This piece “What Cell Biology Reveals About Academia” is a reminder that everyone has the potential to be either seen or unseen.    sciencepolitics.org/2026/03/…
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Bahmanyar lab retweeted
Happy to share this collaborative work published in @Nature today: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly” by @OlzmannLab @apsarruda , led by co–first authors @alymathiowetz and @EmilyMeymand nature.com/articles/s41586-0…
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Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles nature.com/articles/s41589-0…
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Bahmanyar lab retweeted
Very happy to see my corresponding author paper out in MBoC (@ASCBiology). Here we explore the organisation of the yeast seipin complex across lipid droplet formation and find interesting aspects of protein recruitment and wiring to nutrient availability. molbiolcell.org/doi/10.1091/…
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Bahmanyar lab retweeted
The #ABRCMS2025 conference was my first scientific meeting as an undergrad, and it was the experience that propelled me into science. Being back this week, surrounded by brilliant, aspiring young scientists, has been incredible. #Seeingisbelieving
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Ever wanted to do a genome-scale CRISPR screen for a microscopy-based phenotype? Pooled CRISPR screens are amazing, but hard to combine with microscopy... Excited to share a technology platform for such imaging screens and applications to primary cilia... cell.com/developmental-cell/…
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Thrilled to share our work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes. nature.com/articles/s41594-0…
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Bahmanyar lab retweeted
I'm thrilled to share our new preprint, in which we've found that neurotransmitters can be chemically "marked" as a way to incorporate metabolic history - such as diet or life stage. biorxiv.org/content/10.1101/… Led by Porhathai "Un" Malaiwong, Allen Schroeder and Tia Brown. 🧵(1/6)
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