Cilia, centrioles, signaling & cell cycle - Yale University - Molecular, Cellular & Developmental Biology
New Haven, CT
Joined June 2017
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David Breslow lab retweeted
✨️ Exciting opportunity to join MCDB at Yale!
MCDB is hiring a Tenure-Track Assistant Professor in Synthetic Biology and Genomics with an anticipated start date of July 1, 2027. 🧪 👨🔬 👩🔬
Apply here: buff.ly/eMOluTm
Excited and grateful to be chosen as the 2026 ASCB Innovation in Research Award recipient! I especially want to thank all lab members, whose research is recognized here. Congrats as well to the other ASCB honorees.
Congratulations to the 2026 ASCB Honorific Award Winners!
This year's recipients are recognized for outstanding achievements in research, education, mentoring, leadership, and inclusion that continue to advance cell biology.
See the full list:
ascb.org/society-news/ascb-a…
David Breslow lab retweeted
Carolyn Ott @HHMIJanelia, Jennifer Lippincott-Schwartz @JLS_Lab & David Breslow @DavidBreslowLab review how recent advances have expanded our models of how, when & where primary cilia disassemble & discuss emerging roles of altered disassembly in disease.
journals.biologists.com/jcs/…
ALT Schematic showing the mechanisms contributing to cilia disassembly.
David Breslow lab retweeted
Also in Issue 13:
- Research Highlights on a fungal virulence factor, ER-Golgi contact sites, ammonium transporters and neuron-epidermal attachment.
- Opinion on the response to lysosomal damage
- Primary cilium disassembly Review
journals.biologists.com/jcs/…
ALT Schematic showing the mechanisms contributing to cilia disassembly.
David Breslow lab retweeted
Please come join me in Washington, DC August 2-6th for the FASEB SRC on Cilia and Centrosomes meeting! Over 40 talks will be selected from abstracts. We are also excited to launch our first North American Ciliopathy Summit, held at the same venue on Aug 2. events.faseb.org/event/cilia…
David Breslow lab retweeted
Imaging-based CRISPR genome screening allows effects of cell-regulating molecules & modifications to be revealed in live & fixed cells – applied here to frog embryo cilia
📹 Jingbo Sun et al @DavidBreslowLab @Yale in @Dev_Cell
➡️ bpod.org.uk/archive/2026/1/2…
Ever wanted to do a genome-scale CRISPR screen for a microscopy-based phenotype? Pooled CRISPR screens are amazing, but hard to combine with microscopy... Excited to share a technology platform for such imaging screens and applications to primary cilia... cell.com/developmental-cell/…
SMIM27/TZMP1 KO cells don't form cilia. TZMP1 localizes to the transition and by IP/MS is part of the MKS complex at the transition zone. With Mustafa Khokha, we find conserved roles in ciliary function in Xenopus embryos.
David Breslow lab retweeted
Online now: A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology dlvr.it/TPNHyB
Excited to share our latest work on a new cilia disassembly pathway & a link between this pathway and the neurological disorder focal cortical dysplasia: science.org/doi/10.1126/scia…
Summary: From a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
3) it is noteworthy that a GOF CRISPRa screen was able to uncover a connection to a disorder caused by somatic activating mutations; possibly CRISPRa screening may be broadly useful for studying such diseases caused by somatic mutations ...