@AnzyMiller

Research Fellow, University of Manchester

 Manchester, England
Joined April 2013
  • Tweets150
  • Following153
  • Followers135
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Are you interested in exploring the interplay between dynamic protein expression and cell division, and how they impact fate decisions in neural development? We are looking for a PhD student to combine live imaging, optogenetics and data modelling. @BigaVeronica @TheAsheLab
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To join our MRC funded PhD programme @FBMH_UoM apply before 15/11/24. #PhD #Stemcell #Oscillations #CellFate #CellDivision. The impact of cell division on the decoding of oscillatory gene expression during neurogenesis at The University of Manchester on FindAPhD.com
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Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. @Dev_journal journals.biologists.com/dev/…

Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robust...

Summary: Cell-cell coupling at population level compensates for abnormal dynamic Her6 gene expression at single-cell level, resulting in rescued early development and a mild phenotype at late stages.

journals.biologists.com
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The day is FINALLY here! The green light has been given by Swedish authorities for a first-in-human clinical trial with the stem cell therapy STEM-PD for treatment of Parkinsons disease! cam.ac.uk/research/news/clin… @ParmarLab @SCICambridge @BrainRepair_VGB @Kirkeby_Lab

Clinical trial for new stem cell-based treatment for Parkinson’s disease given go ahead

The Swedish Medical Products Agency has granted approval for the trial to proceed; ethical approval has already been obtained from the Swedish Ethics Review Authority. The team, led from Lund...

cam.ac.uk
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Anzy Miller retweeted
Teresa Rayon@t_rayon3 Jan 2024
🚨we’re looking for a Postdoc (2-years initially) 🐭⌛️ 📩 drop an email for further info Closes Jan 31st
Babraham Institute@BabrahamInst3 Jan 2024
VACANCY: Postdoctoral Research Scientist Looking for a new role this year? Check out this opportunity to contribute to our understanding of tempo in mammalian development ⏰ babrahaminstitute.livevacanc…
Mice embryos stained in purple. Text: The Rayon lab is looking for a postdoc to join the lab to play a central role in studying the molecular and metabolic mechanisms that control developmental timing. Deadline: Wednesday 31st January

ALT Mice embryos stained in purple. Text: The Rayon lab is looking for a postdoc to join the lab to play a central role in studying the molecular and metabolic mechanisms that control developmental timing. Deadline: Wednesday 31st January

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!!Job advert alert!! We are looking for an enthusiastic postdoc with molecular biology expertise and a strong interest in developmental and/or cancer biology to join our team. Apply before Feb 5th: thenode.biologists.com/jobs/…

Post-doc in Molecular Developmental and Cancer Biology - the Node

We wish to recruit an ambitious, self-motivated Research Associate (Post-Doc) to join our interdisciplinary research group studying the control of cell-state transitions, which are important for...

thenode.biologists.com
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We identified that the #SOX2 protein oscillates every 17h in proliferative and quiescent #glioblastoma stem cells. Interestingly, the #OscoNet algorithm predicted thousands more genes to oscillate 🤯 Our paper is out: nature.com/articles/s41598-0…

Identification of genes with oscillatory expression in glioblastoma: the paradigm of SOX2

Scientific Reports - Identification of genes with oscillatory expression in glioblastoma: the paradigm of SOX2

nature.com
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Yay my decoding NGN3 #oscillations paper is now in review, fingers crossed for a friendly reviewer 3 🤣
Papalopulu Lab@PapalopuluLab17 Jan 2024
How do cells decode #TF oscillations and how does this impact development? We find #NGN3 protein oscillates in #pancreatic endocrine cells, #oscillations are likely decoded via fold-change and impact on the timing of differentiation, but not fate choice: papers.ssrn.com/sol3/papers.…
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We are looking for a talented, self-motivated and collegial post-doc, with passion for #liveimaging, molecular biology expertise and a desire to understand the mechanisms of #cellstatetransitions in #development and #cancer. Apply before June 10th! jobs.manchester.ac.uk/intern…
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A new preprint from us! We use the SunTag system to image translation from single mRNAs in the Drosophila embryo and uncover translational regulation of the zygotic hunchback mRNA. Work by @DaisyJVinter, @Caro_Hoppe, Cath Sutcliffe, and @TomMinchington biorxiv.org/content/10.1101/…

Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila...

The Hunchback (Hb) transcription factor is critical for anterior-posterior patterning of the Drosophila embryo. Despite the maternal hb mRNA acting as a paradigm for translational regulation, due to...

biorxiv.org
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In the latest preprint a phase-dependent relationship between Hes1 and cell-cycle is shown to underlie #cellcycle length heterogeneity in ER+ #breastcancer cells. Congratulations to the authors @nitin_sabherwal @Andyrowntree @JochenKursawe @papalopulu biorxiv.org/content/10.1101/… 1/6
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Excited to see that my first, first-author paper with @samgriffjon and @PapalopuluLab is now out! Do you work on dynamically expressed proteins? Probably. Check to see if your favourite transcriptional regulator features in our results. nature.com/articles/s41598-0…

Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA...

Scientific Reports - Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback

nature.com
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I'm excited to share my first first-author publication that is out now in @Dev_Cell. An exciting collaboration between @TheAsheLab, @MagnusRattray and @TomMinchington. We show how the Drosophila embryo decodes the BMP signaling gradient at single-cell resolution. (1/7)
Developmental Cell@Dev_Cell5 Aug 2020
New Article online now at Dev Cell: Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo - zpr.io/HzDW3

Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP...

Hoppe et al. show that BMP target genes undergo bursts of transcriptional activity in the Drosophila early embryo. BMP signaling level modulates the frequency of transcriptional bursts by controlling...

cell.com
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Cells in tissue are using ‘group chats’ to make decisions! Multiscale synthesis of fine-grained protein expression of HES5 reveals locally co-ordinated clusters and stripes that control rate of progenitor differentiation. bioRxiv: biorxiv.org/content/10.1101/… 1/5
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Anzy Miller retweeted
Herbert Lab@HerbertLab28 Jul 2020
WE’RE HIRING! Are you a cell or developmental biologist? Are you interested in how cells coordinate multiple processes during tissue morphogenesis? Join our team! We’re looking for TWO new research associates! nature.com/naturecareers/job… #sciencejobs #postdoc @jobRxiv @the_Node
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How do cells make cell state transitions? @PapalopuluLab @XimenaSoto40 et al reveal a #miRNA-driven mechanism counteracting noise and ensuring oscillatory expression of transcriptional regulators during #zebrafish neurogenesis embopress.org/doi/10.15252/e…
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Latest preprint by @TomMinchington @samgriffjon decomposes gene regulation into simple motifs showing that dual feedback motifs (auto-regulatory TF+microRNA) are prevalent and thus could drive dynamic expression in many genes found in human. biorxiv.org/content/10.1101/…
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Exciting PhD opportunity with the up and coming PI of the moment Dr Guilherme Costa. If you are interested in RNA localisation, angiogenesis or ideally both then you should check out this fantastic opportunity: findaphd.com/phds/project/rn…
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