@HerbertLab

Exploring instructive cues encoded in cell shape – in vascular development, morphogenesis and beyond.

 Manchester, England
herbertlab.com/
Joined February 2019
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If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, please check out our new manuscript - mRNA trafficking controls cell-size-scaled organelle dynamics! nature.com/articles/s41467-0…

mRNA trafficking directs cell-size-scaling of mitochondria distribution and function

Nature Communications - How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA...

nature.com
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Our first post in 4-years! Very excited to share our work just published in @ScienceMagazine. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” – in angiogenesis and other tissues! science.org/doi/abs/10.1126/…

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could...

science.org
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LAST CHANCE TO APPLY! If you love zebrafish, RNA, and imaging please apply for our Research Associate vacancy! Deadline for applications is 4th March. #zebrafish #RNA #postdoc jobs.manchester.ac.uk/displa…

Research Associate in Cell and Tissue Dynamics :Oxford Road, Manchester

jobs.manchester.ac.uk
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Do you love RNA? Optogenetics? Developmental Biology? Then we have the perfect job for you!! 4 years Research Associate postion - apply here: jobs.manchester.ac.uk/displa…

Research Associate in Cell and Tissue Dynamics :Oxford Road, Manchester

jobs.manchester.ac.uk
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Herbert Lab retweeted
Raman Das@Raman_Das835 Jan 2021
Despite the national lockdown the 3rd North of England Developmental Biology (virtual) Symposium is still going forward on the 15th of January! Registration is free and everyone is welcome! Join us at: bit.ly/39WfbWq
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In the latest preprint a phase-dependent relationship between Hes1 and cell-cycle is shown to underlie #cellcycle length heterogeneity in ER+ #breastcancer cells. Congratulations to the authors @nitin_sabherwal @Andyrowntree @JochenKursawe @papalopulu biorxiv.org/content/10.1101/… 1/6
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Our first RNA localisation publication! Fantastic effort from Guilherme Costa (now group leader @QUBelfast), and @joshjbradbury and Nawseen Tarannum embopress.org/doi/full/10.15…

RAB13 mRNA compartmentalisation spatially orients tissue morphogenesis

The EMBO Journal - Polarised targeting of diverse mRNAs to cellular protrusions is a hallmark of cell migration. Although a widespread phenomenon, definitive functions for endogenous targeted mRNAs...

link.springer.com
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Hypothesising that these RNAs share a common localisation mechanism, we then used the MS2 system to identify a shared 3’UTR motif that directed localisation to sites of emerging filopodia.
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Perturbation of RNA targeting by genomic excision of localisation elements caused filopodia to depolarise in cultured endothelial cells and, importantly, caused mispatterning of blood vessels in vivo!
Excited to see that my first, first-author paper with @samgriffjon and @PapalopuluLab is now out! Do you work on dynamically expressed proteins? Probably. Check to see if your favourite transcriptional regulator features in our results. nature.com/articles/s41598-0…

Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA...

Scientific Reports - Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback

nature.com
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WE’RE HIRING! Are you a cell or developmental biologist? Are you interested in how cells coordinate multiple processes during tissue morphogenesis? Join our team! We’re looking for TWO new research associates! nature.com/naturecareers/job… #sciencejobs #postdoc @jobRxiv @the_Node
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Our first lock-down lab meeting!
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Herbert Lab retweeted
the Node@the_Node5 Mar 2020
18. 2xPostdoc positions: subcellular mRNA targeting, cell shape and tissue morphogenesis in zebrafish With @HerbertLab @OfficialUoM 🇬🇧 thenode.biologists.com/postd… thenode.biologists.com/postd…
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miR-9 mediated noise optimization of the her6 oscillator is needed for cell state progression in the Zebrafish hindbrain biorxiv.org/content/10.1101/…
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Shane has just given a great talk at #CBDB19 about exciting recent work on mRNA localisation in our lab!
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Our super PhD student @sabrinaghd is here giving a great talk about her work at #CBDB19
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Hello Twitter! #ourfirstTweet
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