Research group at the University of Edinburgh using genome editing and targeted protein degradation to study genetic disease and therapy
The University of Edinburgh
Joined December 2013
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Andrew Wood retweeted
Out now. A collaboration with Sofia Lövestam, Masato Hasegawa and Sjors Scheres. We report that tau filaments extracted from the brains of individuals with Alzheimer’s disease and corticobasal degeneration breed true in the brains of wild-type mice. nature.com/articles/s41586-0…
Andrew Wood retweeted
Incredibly excited to report today on the determinants of toxicity to systemic therapy in cancer patients. Led by many including Alex Guo, Feiyang Huang, Saksham Mohan, River Walser, and the fearless @ZiadBakouny. Co-led by Wes Tansey and Jian Carrot-Zhang medrxiv.org/content/10.64898…
Andrew Wood retweeted
We're hiring a Postdoctoral Research Associate at @MRC_MBU Cambridge
Join our @ARIA_research Precision Mitochondria project with Bitrobius Genetics to develop novel technologies for mitochondrial DNA delivery and genome engineering
🔗 cam.ac.uk/jobs/research-asso…
Please share! 🙏
Andrew Wood retweeted
Beautiful new UK Wnt paper out now in @NatureGenet by Peter Hohenstein @AndrewWoodLab and Derya Ozdemir @UniLeidenNews @EdinburghUni @kocuniversity characterising the molecular/functional impact of numerous CTNNB1 mutational variants in human cancer.
nature.com/articles/s41588-0…
Andrew Wood retweeted
Nature research paper: Hepatic zonation determines tumorigenic potential of mutant β-catenin
go.nature.com/4nZHB4h
Andrew Wood retweeted
Major new direction in the @stark_lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @mike_tilapia lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint biorxiv.org/content/10.1101/…
Andrew Wood retweeted
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
Andrew Wood retweeted
The big one is finally out!! In this paper, we set out to provide insight into the fundamental question;
How do the individual cells from complex tissues regulate their proteomes?
Brief summary of our findings 👇
biorxiv.org/content/10.1101/…
Andrew Wood retweeted
Know it before you tag it!! 🏷️🧬
Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest.
biorxiv.org/content/10.1101/…
Andrew Wood retweeted
🚨We are recruiting🚨. We have a @UKRI_News funded position available @mrc_hgu for a Research Assistant working on Polycystic Liver Disease with @scott_wad_dell
& @Mill_lab ! If you are interested in #organoids, #singlecell and disease modelling then apply! job: 11386 & link👇
Andrew Wood retweeted
Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/scie…🧵(1/n)
Andrew Wood retweeted
Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/scie…
Andrew Wood retweeted
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s41586-0…
Andrew Wood retweeted
What if I told you that I co-founded a startup in 1987 that obtained world-wide rights to GLP1 as a metabolic Rx, collaborated with Pfizer to show key activities, & abandoned it in 1990 when Pfizer lost interest? I tell the previously untold tale in an open access paper now up in Perspectives in Biology and Medicine. Enjoy! muse.jhu.edu/pub/1/article/9…
Andrew Wood retweeted
🚨RTs please🚨
Apply to join our spatial hackathon, full details below and the call is looking for applicants across a range of computational, biological and clinical disciplines.
👇👇
Applications for our Spatial Biology Data Challenge, in partnership with @MRCMouseNetwork, are now open!
Collaborate with and compete against teams of data and cancer experts to overcome the challenges of using large-scale spatial biology data.
Apply by 16 September.
Andrew Wood retweeted
1st #prerpint from the lab together with @briscoejames!
biorxiv.org/content/10.1101/…
Collaborative effort led by @SNakanoh & Despina Stamataki, with contributions from @enabel_sp, @azziChiA, Alex Pokhilko, and help from proteomics (Crick & BI) + bioinformatic teams 🥂
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Andrew Wood retweeted
Congratulations to our Director, Sara Wells, who has received an MBE in the King's Birthday Honours List 2024 for services to medical research!
har.mrc.ac.uk/news/dr-sara-w…
Andrew Wood retweeted
Celebrate emerging talent!
Nominate an exceptional young investigator for the Balfour Lecture Award and recognize their remarkable contributions to genetics (nominee has to have <10 years postdoc experience).
genetics.org.uk/medals-and-p…
Andrew Wood retweeted
Thrilled to see @boulter_lab receive EASL emerging leader award. Thoroughly well deserved. @EASLnews @EASLedu @mrc_hgu @EdinUni_IGC @EdinburghUni
Andrew Wood retweeted
Excited to share: ‘Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo’
life-science-alliance.org/co…
Discover how a chromosome translocation drives one of the most aggressive solid tumors in human.
@georgemias @EhabHannaMD @HCCvPDAC @AndrewWoodLab @amyralston @michiganstateu
