@GeneticsMike7

Geneticist and stem cell biologist studying epigenetics and neurodegeneration @WhiteheadInst @MIT. B.S. @Muhlenberg Ph.D. @Penn

 Cambridge, MA
scholar.google.com/citations?user=BIUDa94AAAAJ&hl=en&oi=ao
Joined May 2021
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1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
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Mike Gallagher retweeted
medRxiv@medrxivpreprintJan 26
GLP-1R expression protects against 58 diseases but raises risk for 34 diseases and neonatal health medrxiv.org/cgi/content/shor… #medRxiv
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Letter: jeffersoncouncil.org/news/fa…

Commentary from a UVA Senior Tenured Faculty Member — The Jefferson Council

The would-be labor unionists of the UVA chapter of the AAUP claim that the UVA Faculty Senate is more representative than the AAUP itself, and naturally the officers of the Faculty Senate concur. But...

jeffersoncouncil.org
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Replying to @GeneticsMike7 @WhiteheadInst @MITBiology @MIT @Harvard @wyssinstitute
20/ strangely, leaky SALL1 is not due to unwanted splicing in the absence of drug, but rather the unspliced pre-mRNA somehow escapes the nucleus and is translated in-frame to make the full-length protein. We still don't know how this works.
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21/ in summary, this "iPSC-Xon" system overcomes critical limitations in current transgene systems in hPSC-based work, and will benefit from additional improvements. I'm on the job market and would love to bring and improve this technology to other researchers!
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