StarkLab retweeted
Congratulations to @FilipNemcko PhD (@stark_lab, IMP), who recently defended his thesis: 'Systematic identification and functional characterization of transcriptional regulators' - Well done Filip! 🥂🍾 @univienna @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs
StarkLab retweeted
Nature biotechnology highlighting ours @stark_lab and @steinaerts @ibrahimihsan recent work on designing cell type-specific enhancers 🎉
Research Highlight: Designer enhancers for cell-type-specific gene regulation nature.com/articles/s41587-0…
StarkLab retweeted
Research Highlight: Designer enhancers for cell-type-specific gene regulation nature.com/articles/s41587-0…
We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature nature.com/articles/s41586-0…. Thread 👇(1/N)
See also the related and complementary work by @ibrahimihsan @steinaerts (@VIBlifesciences) in fly brains nature.com/articles/s41586-0… – together, these publications are the first to read & write enhancer DNA in vivo. (9/N)
Cracking the 2nd code of life has been a major goal of @AlexanderStark8 and the @stark_lab since their start at the @IMPvienna @ViennaBioCenter in 2008. Big thanks to all members and collaborators, especially @deAlmeida_BP & @Eileen_Furlong who made this possible! (fin)
StarkLab retweeted
Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila biorxiv.org/cgi/content/shor… #bioRxiv
StarkLab retweeted
Excited to share the final version of my Postdoc work in the @stark_lab on mapping and unravelling the regulatory specificities between transcriptional corepressors (CoRs) and active enhancers. (1/5)
science.org/doi/10.1126/scie…
StarkLab retweeted
Transcription pre-initiation complex formation & composition is not as uniform as we thought:
@stark_lab @IMPvienna finds distinct PICs acting at housekeeping vs. developmentally-regulated promoters in Drosophila cells
#RefereedPreprint via @ReviewCommons
embopress.org/doi/10.15252/e…
StarkLab retweeted
🚨 Research paper alert!
Functionally distinct #promoter classes initiate transcription via different mechanisms, according to @LeoSerebreni from the @stark_lab & co-authors. Read more in our interview with him. 👇🏽 1/3
imp.ac.at/news/article/custo…
StarkLab retweeted
Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)
News article: imp.ac.at/news/article/decod…
Paper: genome.cshlp.org/content/ear…
StarkLab retweeted
Monika Heinzl from @jkulinz joined the lab of Alex Stark @stark_lab at @IMPvienna to understand and predict the DNA-sequence encoding of enhancer activity.
StarkLab retweeted
The @stark_lab investigates how transcription is regulated at the enhancer and core-promoter DNA level & the proteins involved in activation. Their aim is to comprehend transcription, how it defines cellular and developmental programs via transcriptional networks. @IMPvienna
