@AndreassonLab

We use yeast to understand the molecular mechanisms of cellular protein homeostasis. Account is run by members of the lab.

 Stockholm, Sweden
andreassonlab.com/
Joined January 2021
  • Tweets374
  • Following921
  • Followers1.1K
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… aaand the Andréasson lab is finally online! Make sure to visit our new homepage, where we post about #proteostasis, current projects and #jobopportunities! andreassonlab.com/

Andréasson lab

andreassonlab.com
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From MBoC Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding Cells counteract stress by inducing adaptive transcriptional programs. Hsf1 in yeast is solely responsible doi.org/10.1091/mbc.E23-05-0…
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Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. sciencedirect.com/science/ar…
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Latest paper from my former lab- congrats, guys ⁦@AndreassonLab ⁩Protein misfolding releases human Heat Shock Factor 1 (HSF1) from HSP70 latency control sciencedirect.com/science/ar…
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Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with @BukauLab @hauryliuk and many others! rdcu.be/dyFTI
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I'm so happy that the first paper from my PhD is finally published🙊. We define the tethers in the yeast vacuole-lipid droplets #membranecontactsite and their role in microlipophagy. Major thanks to all the people that contributed to make this story happen 😁
BüttnerLab@ButtnerLab14 Feb 2024
We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-cell/…

LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

Álvarez-Guerra et al. identify the tethering machinery of the membrane contact site that enables lipid droplet consumption via lipophagy. They show that nutrient exhaustion drives the formation of...

cell.com
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Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with @BukauLab @hauryliuk and many others! rdcu.be/dyFTI
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AndréassonLab retweeted
BüttnerLab@ButtnerLab14 Feb 2024
We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-cell/…

LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

Álvarez-Guerra et al. identify the tethering machinery of the membrane contact site that enables lipid droplet consumption via lipophagy. They show that nutrient exhaustion drives the formation of...

cell.com
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AndréassonLab retweeted
BüttnerLab@ButtnerLab12 Jan 2024
We are very proud to share our latest work describing the role of nuclear Hsp104 in protecting the translation machinery during quiescence nature.com/articles/s41467-0…
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AndréassonLab retweeted
Beckmann Lab@BeckmannLab30 May 2023
🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM
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We're happy to share a new paper (the 1st one!) from our SUMO project. A short summary follows. jbc.org/article/S0021-9258(2…

Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its...

Protein SUMOylation is a ubiquitylation-like post-translational modification (PTM) that is synthesized through an enzymatic cascade involving an E1 (SAE1:SAE2), an E2 (UBC9), and various E3 enzymes....

jbc.org
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Publication alert 🚨In our manuscript, we provide robust methods to biochemically and structurally analyze #mitoribosomes: Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipitation pubmed.ncbi.nlm.nih.gov/3716… @Ott_MitoLab #Mitochondria

Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipit...

Mitochondrial protein biosynthesis is maintained by an interplay between the mitochondrial ribosome (mitoribosome) and a large set of protein interaction partners. This interactome regulates a...

pubmed.ncbi.nlm.nih.gov
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The TIM23 translocase of the inner membrane of mitochondria stabilizes PINK1 and thereby directly influences the distribution of Parkin. Beautiful mechanistic @CellReports study by Toshihiko Oka and Toshiya Endo relevant for mitophagy and parkinson. cell.com/cell-reports/fullte…
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Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding | bioRxiv biorxiv.org/content/10.1101/…

Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response select...

Heat Shock Factor 1 (Hsf1) in yeast drives the basal transcription of key proteostasis factors and its activity is induced as part of the core heat shock response. Exploring Hsf1 specific functions...

biorxiv.org
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Check out this week's selection of publications on #MembraneContactSites! biomed.news/bims-mecosi/2023… My favourite: doi.org/10.1038/s41556-023-0… Thanks to @Bims_BiomedNews for the pre-selection! #ParkinsonsDisease #Neurodegeneration #MCS #Mitochondria #QualityControl #ESCRT
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AndréassonLab retweeted
EmSontagMU@EmSontagMU20 Apr 2023
IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12 #proteostasis #proteinfolding nature.com/articles/s41556-0…
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Chaperone-directed ribosome repair after oxidative damage: Molecular Cell cell.com/molecular-cell/full…

Chaperone-directed ribosome repair after oxidative damage

Yang et al. describe the discovery of ribosome repair, where oxidized ribosomal proteins are released by protein-specific chaperones and replaced with newly made intact proteins. This occurs in...

cell.com
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Back-to-back JBC papers! Happy to share another JBC paper @jbiolchem on the phase separation of bacterial nucleoid-associated proteins. A great collaboration with my departmental colleague, P. Guptasarma @guptasarma_p & his lab @pglab_iiserm @DBS_IISERM doi.org/10.1016/j.jbc.2023.1…
Samrat Mukhopadhyay@SamratLabMohali21 Apr 2023
Happy to share our 4th paper in the Journal of Biological Chemistry (JBC) @jbiolchem (new role of ATP in yeast prion conversion). Congrats @SayantaIISERM (co-corresponding) @AnushaSarbahi (co-first) @_NehaPunia @AshishJ87810510 @AnamikaAvni @anuja_walimbe doi.org/10.1016/j.jbc.2023.1…
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The proteomic landscape of genome-wide genetic perturbations cell.com/cell/fulltext/S0092…

The proteomic landscape of genome-wide genetic perturbations

By combining functional genomics with proteomics, molecular phenotypes in the yeast Saccharomyces cerevisiae can be assigned at genome scale, and systems-level insights reveal principles of how gene...

cell.com
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The phosphorylation status of Hsp82 regulates mitochondrial homeostasis during glucose sensing in Saccharomyces cerevisiae #Proteostasis sciencedirect.com/science/ar…
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Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection pubs.acs.org/doi/10.1021/acs…

Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome...

Abstract. A hexanucleotide repeat expansion (HRE) in an intron of gene C9ORF72 is the most common cause of familial amyotrophic lateral sclerosis and front

pubs.acs.org
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