@BukauLab

Our research group @ZmbhH is interested in protein biogenesis and quality control. This account is run by the members of the @BukauLab.

 Heidelberg
Joined October 2020
  • Tweets25
  • Following89
  • Followers710
2Media
Our first 2021 paper reveals the prevalence and mechanism of a co-translational protein assembly mechanism in human cells: co-co assembly. Congratulations to the co-co team @KaiFenzl, @matildebertolin and @guenter_kramer! science.sciencemag.org/conte… @Sciart by @munafomarzia 1/6
6
32
13
182
What shall Germany deliver next? A good question posed by @faznet, thanks 🙏🏻 Well, the answer is obvious: Ukraine desperately needs 🇩🇪 fighter jets Tornados & Eurofighters💪 Dear German Government, please do not hesitate Just do the right thing! m.faz.net/aktuell/politik/au…
356
95
13
653
85,788
Great news! Together with @sjtans & @The_Ban_Lab, we are among this year's recipients of a Synergy Grant from @ERC_Research. This marks the beginning of an exciting journey into a mechanistic analysis of the biogenesis of protein complexes 🧬
10
7
1
145
Our team will combine advanced ribosome profiling, cryo-EM and single-molecule experiments, to study how multiple ribosomes, mRNAs, nascent chains, chaperones and other factors form dynamic super-assemblies that act as coordinated protein complex assembly lines.
1
14
Hier eine schöne Allegorie wie das von @LabJoazeiro und @PfefferCryoLab beschriebene MutS2 Protein fehlerhafte Proteinbiosynthese anhand kollidierter Ribosome erkennt und verschiedene Qualitätskontrollmechanismen initiiert bevor das fehlerhafte Protein der Zelle schaden kann.
Uni Heidelberg@UniHeidelberg10 Mar 2022
Auffahrunfall auf der „Ribosomen-Autobahn“: Wissenschaftler identifizieren bakterielles Protein, das „stehengebliebene“ Ribosomen erkennt und rettet @ZmbhH uni-heidelberg.de/de/newsroo…
Deutsch: Kryo-EM-Struktur der kollidierten Ribosomen mit MutS2. Die verschiedenen molekularen Bestandteile wurden unterschiedlich eingefärbt (stehengebliebenes Ribosom: orange; kollidiertes Ribosom: grün; MutS2: blau; mRNA: pink). Bild: Sebastian Filbeck (ZMBH)

ALT Deutsch: Kryo-EM-Struktur der kollidierten Ribosomen mit MutS2. Die verschiedenen molekularen Bestandteile wurden unterschiedlich eingefärbt (stehengebliebenes Ribosom: orange; kollidiertes Ribosom: grün; MutS2: blau; mRNA: pink). Bild: Sebastian Filbeck (ZMBH)

1
7
How do cells fire up the #RQC engine? Check out our structural and mechanistic blueprint for bacterial #ribosome collision sensing by MutS2, out today in @Nature. MutS2 senses collisions and splits ribosomes to initiate RQC! nature.com/articles/s41586-0…
6
16
4
78
B. subtilis MutS2/RqcU deals with stalled ribosomes by binding collided disomes, recruits the RNA degradosome and initiates #RQC by #ribosome splitting. Happy we could contribute to this work led by @LabJoazeiro in collaboration with @PfefferCryoLab xitter.cf/ZmbhH/status/150159148…
ZMBH - Center for Molecular Biology Heidelberg@ZmbhH9 Mar 2022
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature nature.com/articles/s41586-0…
2
1
14
A new study by the @bukaulab in @CellReports sheds light on role of Nt acetylation in eukaryotes cell.com/cell-reports/fullte…

Nα-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in...

Friedrich et al. analyze yeast strains lacking the major N-terminal acetyltransferases NatA or NatB. Observed changes of transcription, translation, cellular physiology, and proteome integrity reveal...

cell.com
5
20
Comparative SUMO proteome analysis identifies novel SUMO-controlled regulators in EGFR signaling - paper by a team led by @frauke_melchior embopress.org/doi/full/10.15…
1
3
9
Our data suggest that co-co assembly generally involves neighbouring ribosomes on one mRNA, thereby ensuring specific homomer formation of isoforms and structurally-related proteins which are highly prone to promiscuous interactions inside cells. 5/6
1
5
More details @ScienceMagazine: science.sciencemag.org/conte… 6/6
2
15
Congratulations to our colleagues @ZmbhH for the great work!!
Stefan Pfeffer@PfefferCryoLab30 Nov 2020
How do you synthesize proteins with only half a ribosome? We are excited to share our work on the structural basis of Alanine tailing in bacterial ribosome-associated quality control (RQC). Great collaboration with @LabJoazeiro @ZmbhH. cell.com/molecular-cell/full…
1
5
PNAS selected our joint work with @BukauLab on the mechanism of fiber disaggregation to be highlighted on their journal club blog! @PNASNews blog.pnas.org/2020/11/insigh…
3
20
Read our new article in @nature! Congratulations to Ofrah, Meital and Michael! It was fun working with @BukauLab @london_lab, here's to many more! 🥂 nature.com/articles/s41586-0…
16
20
6
94
And that makes two: The fruits of a fun and productive collaboration with the @lab_rosenzweig on a unique regulatory mechanism of class B JDPs that is essential to DNAJB1s ability to support amyloid disaggregation by HSP70. nature.com/articles/s41586-0…
1
10
2
34
Excited to share our latest work on the mechanism of amyloid disaggregation by the HSP70 chaperone machinery, now published in @nature. Thanks go to @NadinathN, Janosch Hennig, @PaoloDeLosRios and Alessandro Barducci. nature.com/articles/s41586-0…
3
21
4
83
Hermann Bujard (1934 – 2020) – pioneering researcher and visionary science politician | The EMBO Journal embopress.org/doi/full/10.15…
1
7
Load more