Structural biologist and biochemist. CNRS researcher at CBM Orléans. Interested in protein modifications & interactions. Also husband, dad of 3, friend, ☧.

Orléans, France
Joined August 2020
A new group photo on the banks of Loiret ☀️
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Marcin J. Suskiewicz retweeted
[HOMMAGE] Le CNRS a appris avec une grande tristesse le décès de Pierre Joliot, pionnier de la photosynthèse et figure de la recherche au CNRS. Nos condoléances à sa famille et à ses proches. 👉 insb.cnrs.fr/fr/cnrsinfo/hom…
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Marcin J. Suskiewicz retweeted
The vibe on here re: AIxMath is kind of apocalyptic, and what’s true is that highly capable AI models have significant impacts on (non-mathematical!) questions around hiring, journals, etc. But if you just log off in fact the day to day of doing math research is really not so different, except that you can talk to your computer about it and sometimes it’s helpful. What does this help look like? In practice high quality math research has never looked like “run a for loop through open conjectures and try to resolve them all,” and it still doesn’t. Most interesting work does not have the form of a problem set, but is rather an open-ended exploration of some phenomenon. There are lots of ways talking to one’s computer can help with this, but I don’t feel particularly worried that it will be automated. After all, it’s a process that is only done when I say it is! Anyway, it’s a great time to be a congenitally calm mathematician.
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Marcin J. Suskiewicz retweeted
People on this app don't appreciate how well purely human mathematics is doing. People prove major results literally every few weeks, with proofs that are insightful, beautiful, and solve many problems simultaneously. Currently reading this wonderful thing: arxiv.org/pdf/2608.26392
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Marcin J. Suskiewicz retweeted
#100ANS #15SEPTEMBRE2026 Mon père, le #mathématicien #JeanPierreSerre , + jeune médaille Fields à 27ans, prix Abel, médaille d'or du @CNRS, élu prof. au Collège de France à 29ans, racontera le 15 septembre 2026, jour de ses 100ans, ses souvenirs #mathématiques à l'institut Henri Poincaré. #sciences @cdf1530 @InHenriPoincare @abel_prize @Michel_Broue
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Happy to share our preprint on a subset of ZBTB BTB domains as efficient natural SUMO 'supersubstrates'. The work was spearheaded by a great postdoc, El Hadji Cisse, with input from other team members and in collaboration with Defossez and Aucagne labs. biorxiv.org/content/10.64898…
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This property extends to 5 human ZBTB proteins (38, 4, 33, 21, 14). This work continues from our previous study where we found that BTB domains of around 20 different ZBTB proteins form filaments. Now we show that 5 other ZBTB proteins undergo efficient SUMOylation.
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So efficient SUMOylation as a new function of (some) BTB domains + our result support a hypothesis structural SUMOylation motifs pre-organised for productive UBC9 engagement may be more efficiently modified than typical flexible SUMOylation motifs. Might apply to other PTMs.
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Marcin J. Suskiewicz retweeted
If your claim to fame is pushing a button to optimize a breakthrough announced by a junior mathematician a few days ago, it’s not very impressive, to put it politely. Without getting into rumors on the sequence of events…
1/ ✨ World record today on bounded gaps between primes, one of number theory’s oldest open conjectures.  We show that infinitely many pairs of prime numbers are separated by 212 or less.
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Marcin J. Suskiewicz retweeted
Btw Andreas Thom is now also wondering outloud whether OpenAI used his personal user data to train the model to find a non-sofic group... mathstodon.xyz/@andreasthom/…
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Marcin J. Suskiewicz retweeted
This reference list for Navier Stokes blowup is outrageous. No Chen-Hou, no Alpoge-Buckmaster, no Córdoba and Martínez-Zoroa, no Elgindi. They are not properly attributing any previous work to the problem
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I feel there are more points of division at play: utilitarian (things matter if they serve the right goal, ultimately the pleasure/health of individuals) vs. attentive to inherent value; individualist vs. communitarian; universalist (global wellbeing) vs. localist (a web of...
I wonder how much of the divide among mathematicians on AI comes down to which of us consider ourselves scientists and which of us consider ourselves artists. (I'm very much in the former camp but for what it's worth I am sympathetic to the latter.)
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local responsibilities); ready to risk status quo to improve things vs. conserving what is good against entropy; neodarwinian nihilist vs. humanist/religious; libertarian vs. socialist; tenured vs. still in training, etc.
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I follow the AI & math discourse a bit - without understanding the actual math. I thought I might offer some thoughts as a scientist in structural biology - a field transformed by various tech over the years, and recently by AlphaFold. It might perhaps interest @nasqret et al.🧵
I'm currently returning to Toronto from a summit on the future of mathematics, at OpenAI. @SebastienBubeck asked me to talk a bit about the future we'd all like to avoid, where humans are mathematically disempowered. @Jacob_Tsimerman advised us to try to prioritize detail over correctness, and I have no doubt that I succeeded in deprioritizing correctness. I tried to find a title that wasn't too bombastic:
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Sorry, I was editing and pasting as I went, so it's only finished now. Good luck to all the mathematicians navigating changes in their domain! @nasqret
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I don't know if it might be interesting to @littmath , @gro_tsen .
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Marcin J. Suskiewicz retweeted
I'm pleased to share our review on how Human Herpesviruses (HHVs) interact with the host SUMOylation machinery. We discuss viral strategies, molecular mechanisms, and key open questions. Read more: sciencedirect.com/science/ar… #Virology #Herpesvirus #SUMOylation #HHVs
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