Senior Investigator @NIH | Studying how #chromosomes attach to microtubules in mitosis and meiosis | Opinions are my own
Bethesda, MD
Joined September 2017
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Excited to share our new @ScienceAdvances paper! During interphase, centromeres form 3D shells organized by the CENP-A chaperone complex at their core. Led by Hindol Gupta, with the @TakashiAkeraLab , Losada, and Shroff labs.
science.org/doi/10.1126/scia…
Alexander Kelly retweeted
It was wonderful to be part of the group honoring the memory and contributions of David Allis and Gary Felsenfeld to the field of chromatin biology and epigenetics at the National Cancer Institute. @theNCI Thanks to Shiv Grewal @grewalsh, and the organizing committee at NCI for putting this outstanding meeting together. @NIH @NUFeinbergMed @NorthwesternMed @LurieCancer @DrBrianStrahl @MuirLab @berger_lab @CKadoch @GAlmouzni @bernstein_lab @AsifaAkhtar1 @YiZhang_Lab @senergystic @todd_macfarlan @NogalesLab @pioneerfactors @PeterLewisLab @PlathLab @AlexKellyLab
Alexander Kelly retweeted
Hurry! The deadline to register for the exciting symposium on "Histone Modifications and Chromosome Structures" is quickly approaching—this Friday, October 4, 2024. This symposium featuring talks by 25 renowned scientists is free to attend. To secure your spot, please visit: go.cancer.gov/hrxQPuE
Alexander Kelly retweeted
🎉 Exciting Announcement! 🎉
“Histone Modifications and Chromatin Structure Symposium”
🗓️ Dates: October 17-18, 2024
📍 Location: National Institutes of Health, Bethesda, Maryland
The NCI Center of Excellence in Chromosome Biology is delighted to invite you to our upcoming symposium. This symposium honors the legacies of Dr. C. David Allis and Dr. Gary Felsenfeld, pioneers in the study of chromatin and gene expression. Presentations from 25 renowned scientists. For more details and to register, visit: ncifrederick.cancer.gov/even…
Alexander Kelly retweeted
Happy to share our work about DNA supercoiling, an understudied physical feature of the double helix and the chromatin. 1/5
nature.com/articles/s41594-0…
Alexander Kelly retweeted
📢ACCESS DENIED!!
Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited?
Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance
#epigenetics #heterochromatin #histones #chromatin
Congratulations to @rakesh_k_sahu and other lab members!
cell.com/molecular-cell/full…
Alexander Kelly retweeted
We're deeply saddened by the passing of Dr. Maxine Singer, esteemed scientist emeritus at NCI’s Laboratory of Biochemistry and Molecular Biology. Her groundbreaking work and dedication to science have left an enduring legacy. Our thoughts are with her family and colleagues🌹
Comprehensive cancer survivor care is essential. Learn more about the latest here:
June is #NationalCancerSurvivorsMonth. Join @NCICancerSurv all month long in honoring the more than 18 million #CancerSurvivors in this country. cancercontrol.cancer.gov/ocs…
ALT Background photo of an open field and the sun shining through trees. The text reads, “NCI Office of Cancer Survivorship Recognizes National Cancer Survivors Month”
Alexander Kelly retweeted
Preprint🚨on a new mechanism of genetic cheating in meiosis! 🧬We found that a mouse selfish DNA, R2d2, combines the elements of both male and female meiotic drivers! (gamete sabotaging in female meiosis)
biorxiv.org/content/10.1101/…
Alexander Kelly retweeted
My department is hiring! Tenure track faculty position in genetics. Researchers using any eukaryotic model, including fungi and plants are encouraged to apply! We are a broad biology department with strengths across all kingdoms. Join us! Apply by March 1 tinyurl.com/y4evds8p
Our department is looking for a computational biologist. Please help spread the word!
📢Job Opening COMPUTATIONAL STAFF SCIENTIST🌟
The Laboratory of Biochemistry and Molecular Biology (LBMB) at NIH is seeking a Computational Staff Scientist to analyze transcriptional and post-transcriptional processes in eukaryotes. Full job ad here 👉ccr.cancer.gov/careers/staff…
Alexander Kelly retweeted
📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly bit.ly/4b8wpNA
Alexander Kelly retweeted
Now recruiting: enthusiastic postdocs to use advanced imaging methods to dissect biological processes. My group at Harvard has 2 Wellcome-funded positions examining the underlying mechanisms and resultant forces driving bacterial growth, division, and antimicrobial resistance.
Huge thanks to @chienlab @UMassBMB and @UMassMCB for hosting me at the MCB seminar series yesterday! @UMassAmherst has a great community and wonderful trainees, I really enjoyed all of my discussions!