Structural biology and biochemistry lab at IGBMC, Strasbourg, France. We are interested in molecular machines executing gene expression.
Strasbourg, France
Joined March 2020
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AlbertW_lab retweeted
Max Planck President Patrick Cramer @mpgpresident has written an open letter to the President of @Harvard, expressing his full support to the University & its stance against demands from the Trump administration to change its policies in order to retain federal funding @maxplanckpress
ALT A photo of Max Planck President Patrick Cramer, with the words "Threats to science anywhwere are threats to science everywhere."
AlbertW_lab retweeted
We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
AlbertW_lab retweeted
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
AlbertW_lab retweeted
First paper of our lab today @Nature by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl
doi.org/10.1038/s41586-024-0…
Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥
Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher
@embl paper in @biorxivpreprint
biorxiv.org/content/10.1101/…
AlbertW_lab retweeted
Structures of transcription-translation coupling complexes at each stage of the translation cycle
(Collaboration between our laboratory and the laboratories of Yue Gao, Jinzhong Lin, and Chengyaun Wang. Extensively expanded preprint. Posted 07/25/24.)
biorxiv.org/content/10.1101/…
AlbertW_lab retweeted
Happy to share our latest work on DNA topology regulation ! With cryo-EM and magnetic tweezers, we unveil how DNA gyrase captures a DNA crossover in supercoiled minicircles.
doi.org/10.1126/science.adl5…
@Inserm @CNRS @IBENS_ENS @univ_paris_cite @bcmhouston @BCMFromtheLabs @IGBMC
AlbertW_lab retweeted
bioRxiv: Molecular basis of mRNA delivery to the bacterial ribosome dlvr.it/T4KX4p
AlbertW_lab retweeted
How photosynthetic genes are transcribed 🧬🌿 I’m really pleased to share the first work from my group at @JohnInnesCentre published today in @CellCellPress: cell.com/cell/fulltext/S0092…
AlbertW_lab retweeted
Credit for the project goes to first author Lucy @DimitrovaLucy and last author Helge Paternoga, as well as collaborators for mass spectrometry @TanelTenson , RNA-sequencing analysis @GrannemanSander and the @DCI_EM for great cryo-EM data!
AlbertW_lab retweeted
Very grateful for the funding provided by the @ChanZuckerberg Initiative to develop a #CryoCLEM probe with my nascent team at @IGBMC ❄️🔬! Congratulations to the other grantees!
🎉 Meet our new imaging grantees, who are working to improve #CryoCLEM imaging probes so researchers have a more detailed view of cells and help advance our understanding of health + disease
⤵️ bit.ly/46bDvgy
AlbertW_lab retweeted
"Here, we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4, Spt5, and a transcription elongation complex (TEC)."
AlbertW_lab retweeted
Thankful that we were SCOOPED!!!
It forced us to look closer and soon we could see the entire translocation cycle of the protozoan parasite Giardia! Bravo to @majumdar_sonia and @AndyEmmerich, who did the entire craft at @UU_University, the story will soon appear in @NAR_Open!
AlbertW_lab retweeted
Happy to share our recent work on mRNA translation and protein biogenesis at the ER. From >1000 tomograms 'Mad' @MaxGemmer &Co deduce the interplay of polysomes, translocons and chaperones. Great collaboration with @xlinkx_pd and @AbhayKot teams. doi.org/10.1038/s41586-022-0…
AlbertW_lab retweeted
👩🔬👨🔬 @IMC_Bio's #PhD call is open for 2023! 17+ projects are available, this is a great opportunity to train in one of #Strasbourg's state-of-the-art institutes!
More info👇
#research #stemcells, #cancer, #genomics, #biology, #structuralbiology, #neurogenetic, #rna, #immunity
Come and find our offers for doing your #phd #recherche @IMCBio @unistra @IGBMC @ARN67IBMC @CNRS_Alsace @cnrs_ibmp @InsermEst Institute for Viral and Liver Diseases, here as well:
euraxess.ec.europa.eu/jobs/4…
AlbertW_lab retweeted
NEW: In @ScienceMagazine today, our latest peer-reviewed research shows Exxon scientists predicted global warming with shocking skill & accuracy between 1977 & 2003, contradicting the company's decades of climate denial. THREAD.
📰No pay wall for 2 weeks: bit.ly/ExxonKnew2point0
AlbertW_lab retweeted
DALL-E’s amazing images are popping up all over the web. That software uses something called a diffusion model, which is trained to remove noise from static until a clear picture is formed.
Turns out diffusion models can design proteins too!
AlbertW_lab retweeted
Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes | Nature Chemistry nature.com/articles/s41557-0…
AlbertW_lab retweeted
PhD studentship in my lab @JohnInnesCentre to investigate gene expression mechanisms 🧬 that underpin photosynthesis in plants 🌱 using #CryoEM 🔬❄️ (fully funded). @NRPBIODTP
biodtp.norwichresearchpark.a…
AlbertW_lab retweeted
Visualization of linker DNA in situ reveals zigzag motifs of nucleosome chains. We combined VPP cryo-electron tomography and deep learning-based denoising. biorxiv.org/content/10.1101/…
