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Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery.
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#TeamTomo #CryoEM
nature.com/articles/s41586-0…
Max Gemmer retweeted
You always wanted a book on cryo- electron tomography, written by the leading experts in the field? I have good news-You can now pre- order this book, edited by the one and only @FriedrichForst1 and myself! link.springer.com/book/97830…
Max Gemmer retweeted
Muyuan has been working on this for some time, it's cool to see a manuscript: How to create full, atomic resolution scenes of biomolecules in Unreal Engine and fly around them in real-time. Really cool stuff with untapped potential.
eman2.org/unreal_render
biorxiv.org/content/10.1101/…
Max Gemmer retweeted
Happy to report our new structure of Sec61 and the TRAP complex out now in @emboreports! This has been a nice group effort with us @BIOTECH_UH and with @JuhaHuiskonen and @LHapponen @lunduniversity.
embopress.org/doi/full/10.15…
How is the biogenesis machinery organized to produce multispanning membrane in humans? In our most recent preprint, we characterize the composition of the multipass translocon in its native membrane environment using cryo-ET.
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#TeamTomo #cryoEM
biorxiv.org/content/10.1101/…
8 | The function and interplay between TRAP, NOMO, and NCLN remains largely obscure. The architecture of the BOS complex (NCLN-NOMO) and its interaction with the insertase EMC was now characterized by the @voorheeslab. Check out their paper, too!
biorxiv.org/content/10.1101/…
9 | Big thanks to @ChailletMarten, @FriedrichForst1, and the rest of our team for their contributions. The full raw data set of unperturbed ER-derived vesicles from this and our previous paper is now also available online ebi.ac.uk/empiar/EMPIAR-1175…
Max Gemmer retweeted
We developed "DeepFIBing" - a new strategy to create #cryoFIB-lamellae for #cryoET in any depth of very large cells - this also works for tissue. If you want to know more, have a look into our publication in CELL with @jentoft_ida and @SchuhLab. #teamtomo bit.ly/3u3Azp6
I successfully defended my PhD thesis on protein biogenesis last week. I am really grateful to my supervisor @FriedrichForst1, colleagues and friends for this wonderful experience! In particular Juliette Fedry and @ChailletMarten who significantly contributed to our projects.
Want to learn how to create stunning scientific visualizations in #b3d? Check out @bradyajohnston's molecular nodes and @luminous_lab's tutorials on YouTube!
#SciArt
Max Gemmer retweeted
Great symposium to honor the opening of the cryoEM facility in Berlin! Thank you for the invitation @MishaKudryashev, Christian Spahn and Christoph Diebolder. Happy invited speakers Helen Saibil, @FriedrichForst1 and Kay Grünewald
Max Gemmer retweeted
Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites!
So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomo
In situ cryoET reveals inhibitor-induced perturbations in Pf80S GTPase interactions biorxiv.org/cgi/content/shor… #bioRxiv
Max Gemmer retweeted
🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.09.05.5…
Max Gemmer retweeted
Abstract submission is now open! Register for this EMBL workshop on the application of cryo-EM in industry and academia embl.org/about/info/course-a…
