@AlbertW_Lab

Structural biology and biochemistry lab at IGBMC, Strasbourg, France. We are interested in molecular machines executing gene expression.

 Strasbourg, France
Joined March 2020
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We study the cooperation between Molecular Machines. Work by Vita Vidmar and @borde_celine in collaboration with @OlivierEspeli and @valeroche looking at the interplay of #Transcription and DNA topology is out: nature.com/articles/s41594-0… 1/7

DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation

Nature Structural & Molecular Biology - Vidmar et al. use cryo-EM to reveal how bacterial RNA polymerase (RNAP) and topoisomerase I (TopoI) cooperate. TopoI switches conformation, senses DNA...

nature.com
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Big thanks for lots of #TitanKrios time and help to Alexandre Durand @DurandA17996106, Nils Marechal @marechal_nils, @BioS_ME_Alsace, @IGBMC, Michael Hons, Gregory Effantin, and Eaazhisai Kandiah at beamline CM01 @esrfsynchrotron, and @FrommSimon @EmblImaging. 6/7
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We were supported by @IGBMC, @Inserm, @CNRS @unistra, @ERC_research, and @instructhub. 7/7
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Max Planck President Patrick Cramer @mpgpresident has written an open letter to the President of @Harvard, expressing his full support to the University & its stance against demands from the Trump administration to change its policies in order to retain federal funding @maxplanckpress
A photo of Max Planck President Patrick Cramer, with the words "Threats to science anywhwere are threats to science everywhere."

ALT A photo of Max Planck President Patrick Cramer, with the words "Threats to science anywhwere are threats to science everywhere."

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We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
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Please spread the word: we are looking for PhD students! Interested in supramolecular complexes in gene expression? Go to imcbio-phdprogram.unistra.fr scroll down to “Integrated Structural Biology (LabEx INRT)” for project descriptions and start application process by January 19th!
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Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
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First paper of our lab today @Nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl doi.org/10.1038/s41586-024-0…

Tracking transcription–translation coupling in real time

Nature - Single-molecule fluorescence microscopy experiments with a recombinant Escherichia coli transcription–translation system provides insights into the coordination of the transcription...

nature.com
Olivier Duss@OlivierDuss14 Dec 2023
Our new findings on how the ribosome couples with the RNA polymerase are summarized in a movie highlighting the dynamics of the process🎞️🎥 Thanks to Clemens Bretscher for the great animations! - behance.net/cbretscher @embl paper in @biorxivpreprint biorxiv.org/content/10.1101/…
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We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/scie… The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7

Molecular basis of mRNA delivery to the bacterial ribosome

Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the...

science.org
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Closely related work has also been done in the laboratory of Shun-ichi Sekine: biorxiv.org/content/10.1101/… 7/7

Structural insight into bacterial co-transcriptional translation initiation

In bacteria, transcription and translation are tightly coupled, forming a transcription-translation complex (TTC) between RNA polymerase (RNAP) and the ribosome. As nascent mRNA emerging from RNAP is...

biorxiv.org
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We want to thank additional people involved: Kristine Charles, Nataliya Miropolskaya, Maria Takacs, Charlotte Saint-André, Alexandre Durand @DurandA17996106, Nils Marechal @marechal_nils, @BioS_ME_Alsace, Gregory Effantin, and Eaazhisai Kandiah at beamline CM01 @esrfsynchrotron
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