Group Leader at the @JohnInnesCentre | Photosynthetic gene expression 🧬🌿 | Cryo-EM ❄️🔬.
Norwich, UK
Joined September 2012
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How photosynthetic genes are transcribed 🧬🌿 I’m really pleased to share the first work from my group at @JohnInnesCentre published today in @CellCellPress: cell.com/cell/fulltext/S0092…
Michael Webster retweeted
Super lucky to get the Faraday!@royalsociety Very grateful for the support from @JohnInnesCentre, @CarolineDeanLab, @DingLab_RNA, and all the collaborators/friends🙏jic.ac.uk/press-release/roya…
Michael Webster retweeted
Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein.
biorxiv.org/content/10.1101/…
#cryoEM #transcription #splicing
Inspiring example of structural prediction + evolutionary conservation analysis by @amiralito_ in this thread 👇
🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14)
biorxiv.org/content/10.1101/…
Michael Webster retweeted
VACANCY - We have an exciting opportunity for a Cryo-electron Microscopy Support Specialist to join the Bioimaging Platform, collaborating with scientists at JIC and @NorwichResearch
okt.to/si4roe
Closing date - 14 February 2025
Contract - Full-time, indefinite
Michael Webster retweeted
Please spread the word: we are looking for PhD students! Interested in supramolecular complexes in gene expression? Go to
imcbio-phdprogram.unistra.fr
scroll down to “Integrated Structural Biology (LabEx INRT)” for project descriptions and start application process by January 19th!
Really pleased to see this study of gene expression coupling performed so comprehensively! When we determined structures of ribosome-polymerase complexes we knew were seeing the tip of the iceberg- static moments of two machines that should be seen moving. Congratulations!
First paper of our lab today @Nature by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl
doi.org/10.1038/s41586-024-0…
Beautiful cryo-EM reconstructions from our lab neighbour. Delighted to see it out 👇🔬❄️🧬
Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date).
@JohnInnesCentre @DurhamU34989 @MCB_UJ
Michael Webster retweeted
In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics?
eurekalert.org/news-releases…
Michael Webster retweeted
From #cryoEM to #singlemolecule kinetics
science.org/doi/10.1126/scie…
So proud and humble to share this work alongside @WebsterMichael0 and one of my scientific hero @AlbertW_Lab
This is how I envision Science and Collaboration at its best. @NilsWalterLab
Michael Webster retweeted
🌱 Exciting opportunity in the Jarvis Lab @OxfordBiology! We're hiring a 3-year Research Assistant to study the structure & function of the plant chloroplast protein import machinery.
🔬 Help us resolve the structure of the TOC-TIC translocon! Apply here: my.corehr.com/pls/uoxrecruit…
Michael Webster retweeted
We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/scie…
The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7
Michael Webster retweeted
PRESS RELEASE - Delivery mechanism discovery resolves gene expression puzzle
International research collaboration has used advanced microscopy to capture in unprecedented detail a critical moment in gene expression.
okt.to/ewgcsX
@NorwichResearch @WebsterMichael0
Michael Webster retweeted
Joe Ecker @JoeEcker, Joseph Swift @_joseph_swift, and team have revealed the genetic details of 30-million-year-old question: How did some plants evolve from less-efficient C3 photosynthesis to C4 photosynthesis? Their findings pave the way for the creation of more robust, efficient plants that withstand the effects of climate change and can feed a growing global population 🌱 @Nature
salk.edu/news-release/superi…
A few more days to apply 👇 Hopefully an exciting project for a student interested in cryo-EM, biochemistry, biophysics and plants 🪴
We are looking for a PhD student to lead a project in the lab focused on the gene expression mechanisms supporting Rubisco production in plants 🌿🧬👇 Please share and contact me if you'd like to know more. biodtp.norwichresearchpark.a…
Michael Webster retweeted
We are excited to announce the launch of our MSc in Microbiology, and I will be serving as the Program Director for the next academic year. Please feel free to reach out if you would like to learn more about this exciting opportunity.
@biouea
uea.ac.uk/course/postgraduat…
Michael Webster retweeted
VACANCY - We're recruiting a Director to lead our world-renowned, independent, international centre of excellence in plant science, genetics and microbiology.
Please share and apply: okt.to/kURnfW
Closing date - 22 November 2024
@NorwichResearch
Great to see this #cryoEM collaboration between @JohnInnesCentre and @TheSainsburyLab out in its final form. Take a look if you're interested in the fascinating world of plant immunity structural biology.
So happy to see the final version of our paper on the structure of the sensor-activated NRC2 hexamer online! Congrats to @JMadhuprakash and the whole team 👏
Check out Madhu's and @amiralito_'s threads below for the key highlights 👇🧵
science.org/doi/10.1126/scia…
Michael Webster retweeted
We have an open #postdoc position to study the molecular mechanisms of #DNArepair !🧬🔬
The project will build on recent findings nature.com/articles/s41586-0… and established collaborations, using #cryoEM and #SingleMolecule imaging.
Access to fantastic facilities @MRC_LMB .
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