@AdelmanLab

Adelman Lab at Harvard Medical School, BCMP Department

 Boston, MA
adelman.hms.harvard.edu
Joined August 2018
  • Tweets120
  • Following137
  • Followers2.1K
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Congratulations to Karen Adelman, Edward S. Harkness Professor of @HMS_BCMP, for her election as an @EMBO Associate Member! @harvardmed @AdelmanLab
EMBO@EMBO9 Jul 2024
Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community embo.org/press-releases/outs…

Outstanding scientists elected to EMBO Membership – Press releases – EMBO

In the 60th anniversary year, 100 new members and 20 associate members join the community

embo.org
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I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors! biorxiv.org/content/10.1101/…

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chroma...

Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that influences a wide range of cellular processes by regulating transcription. Despite years of study, however, how...

biorxiv.org
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SWI/SNF function compensated by another chromatin remodeller go.nature.com/3RkTG7m #ResearchHighlight by @haertl17
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We have a great lineup of speakers for the the @CEEHRC annual meeting, featuring 2 exciting keynotes this year. Michael Taylor from @TexasChildrens @bcmhouston Karen Adelman @AdelmanLab from @harvardmed who is our Trainee Keynote for this year! event.fourwaves.com/ceehrc20…

CEEHRC 9th Annual Canadian Conference on Epigenetics

Join CEEHRC 9th Annual Canadian Conference on Epigenetics, November 13 to December 8, 2023. Learn more on Fourwaves.

event.fourwaves.com
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AdelmanLab retweeted
Ben Martin@bmart8720 Apr 2023
And there is a nice perspective article by Robert Fisher here: science.org/doi/10.1126/scie…

Tumor suppression by RNA surveillance

A cyclin-dependent kinase triggers degradation of prematurely terminated RNAs

science.org
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Great to see the conclusions from a recent paper from our lab (Stein et al 10.1016/j.molcel.2022.10.004) so nicely recapitulated in a different system !!!
Molecular Cell@MolecularCell19 Apr 2023
Online Now: INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II dlvr.it/Sml3jr

INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase...

Hu et al. reveal that the two catalytic modules of INTAC have unexpectedly general yet distinct roles in transcription: the endonuclease module cleaves nascent RNAs to induce promoter-proximal RNA...

cell.com
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Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  @AdelmanLab @harvardmed
American Academy of Arts & Sciences@americanacad19 Apr 2023
Congratulations to our new members! Just announced! We are honoring the excellence of extraordinary leaders in an array of disciplines and professions. The first members were elected in 1781. Learn who was elected in 2023: amacad.org/news/2023-member-…
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Pedal to the metal--U1 snRNP, known to be important for mRNA splicing, stimulates the elongation rate of RNA polymerase II (RNAPII). This allows RNAPII to transcribe introns more quickly, reducing the chance of transcriptional arrest. @camimoso @AdelmanLab ow.ly/R2m750NvR3E
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with U1 snRNP bound pol2 elongates faster and with fewer stops #ChromatinHaiku
Claudia Mimoso@camimoso24 Mar 2023
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…
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Online Now: U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes dlvr.it/SlQPQQ
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AdelmanLab retweeted
Ben Martin@bmart878 Mar 2023
It took my 25 tweets to share this, but if that (or the manuscript itself) is too long - here is the synopsis in 17 syllables for @ChromatinHaiku: At most promoters P400 compensates For loss of SWI/SNF #ChromatinHaiku biorxiv.org/content/10.1101/…
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Online Now: Integrator is a global promoter-proximal termination complex dlvr.it/Sgk2zj
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Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci dlvr.it/Sd0Bzy
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Online Now: Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci dlvr.it/SbsRkq

Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed...

Stein et al. show that Integrator broadly balances levels of RNAPII pause release with premature termination. Acute depletion of Integrator endonuclease allows for increased RNAPII release into...

cell.com
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Happy Saturday! #EMBLTranscript is about to begin! 🤩 Waiting for everybody to arrive so we can start discussing the latest findings in the #transcription and #chromatin field 🧬🗣️ Can't wait! Have a look at the programme 👇🏽 embl.org/about/info/course-a…
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Less than a month left to submit your abstract for #EMBLTranscript ⏲️ Join us to discuss the latest findings in the #transcription and #chromatin field🧬🗣️ Organisers🔹Karen Adelman @AdelmanLab🔹Eileen Furlong 🔹Jürg Müller @MPI_Biochem🔹Peter Verrijzer 👉🏾 s.embl.org/trm22-01
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1 week to go! Registration & Poster submission for the 3rd #Epigenetics Conference close next Friday. Don't miss out on joining Chairs @giacomo_cavalli, @ludicroce and our superb line up of speakers in Mexico this May☀️ 📆 Deadline: 25 Mar 2022 🌐fusion-conferences.com/confe…
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AdelmanLab retweeted
Emily Kaye@egkaye26 Feb 2022
I am excited to share this new paper I contributed to! This was a collaborative effort investigating the protective role of m6A methylation against nascent RNA cleavage by the Integrator complex. Congrats to Yang Shi, Hongjie Shen, @AdelmanLab, @geoffmnelson and other co-authors!
Molecular Cell@MolecularCell25 Feb 2022
Online Now: Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis dlvr.it/SKg2yv

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

Xu et al. show that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) widely localizes to promoters and enhancers and deposits the m6A modification on nascent transcripts. Further, they...

cell.com
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You’ve thought about it, now go on and apply by Apr. 1! Join @AdelmanLab, @MarcMendillo, and me for @cshlcourses @cshlgnx 2022! You’ll learn a ton, meet leaders in the field, and hang for 3 wks with your fellow future leaders of the field. meetings.cshl.edu/courses.as…

Chromatin, Epigenetics and Gene Expression

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
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Congratulations to @AdelmanLab graduate student @chadbstein on being awarded a NIH F31 predoctoral fellowship from NIAID! @BBS_Harvard #NIH
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