@Pol2Runner

Walter Benjamin Research Fellow @AdelmanLab @harvardmed; PhD @_WolfLab @Uni_WUE.

 Boston, MA, USA
scholar.google.com/citations?hl=en&user=1wfNuS0AAAAJ&view_op=list_works&gmla=AJsN-F4U6bZl6U6
Joined October 2016
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Thrilled to see my postdoc work @AdelmanLab on the Integrator (INT) now out @CellCellPress:We found that INT deficiency allows immature and unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes
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A new study shows mutations in the Integrator complex — linked to cancers, blood disorders, neurodevelopmental abnormalities, and other diseases — cause chronic stress in cells bit.ly/4mIdFdF
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Amazing to see how this work connects defects in transcription elongation to chronic stress signaling and disease! Could targeting dsRNA or ISR pathways offer new therapeutic strategies for conditions caused by INT mutations? Fascinating implications for RNA biology and medicine!
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Thanks to @Wagnerlab_RNA @khurana_lab and SchafferLab for the awesome collaboration that made this work possible! #RNA #StressResponse #RNA #GeneReg #stemcells #Genomics #GeneRegulation Check out the paper here: authors.elsevier.com/c/1kwzm….
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Excited to be at @KeystoneSymp for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #GeneRegulation
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Ernst Schmid@ernstschmidd26 Feb 2025
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. cell.com/molecular-cell/full…

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this...

cell.com
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Join organizers @AdelmanLab, @helin_kristian to discuss emerging research @KeystoneSymp #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25

Epigenetics in Development and Disease | Keystone Symposia

Join us at the Keystone Symposia on Epigenetics in Development and Disease, March 2025, in Banff, with field leaders!

keystonesymposia.org
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Very proud to have been awarded an ERC Consolidator grant for research on neuronal RNAs! Rock on, team!
MPI of Immunobiology & Epigenetics@mpi_ie3 Dec 2024
Wow. Congratulations to Valérie Hilgers (@hilgers_lab) 🎉! She has been awarded the prestigious ERC Consolidator Grant by @ERC_Research! More on her project on alternative processing of RNA molecules in neurons here: ie-freiburg.mpg.de/5985387/2…
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Looking for an exciting #PhD project in #molecularBiology? How about this question: what determines a gene's end? Most human genes have alternative ends, the choice of which is important for health and disease. Yet we still don't understand how this choice is made!
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Apoorva Baluapuri retweeted
G V Pavan Kumar@Pavan_KumarGV31 Mar 2024
All the points in a single blog: backscattering.blog/2024/03/…
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Emily Kaye@egkaye30 Jan 2024
Happy to announce the final version of our paper is now available @NatureComms! nature.com/articles/s41467-0… Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
Emily Kaye@egkaye10 May 2023
I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
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...and here is the official ad 👇👇👇👇👇👇👇👇👇👇👇👇👇👇👇
José Pedro Friedmann Angeli@AngeliFriedmann23 Dec 2023
🔬 Join Our Team! 😎 We're hiring a Postdoctoral Researcher for out #ERC-funded project #DeciFERR focusing on Transporters, Protein Biochem & Pharmacological Screens. If you're passionate about groundbreaking research in these fields, please get in touch! 🙏 for retweeting 🙏
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My RNA didn’t degrade, it just underwent a rapid unscheduled disassembly into nucleotides !!
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Great to see the conclusions from a recent paper from our lab (Stein et al 10.1016/j.molcel.2022.10.004) so nicely recapitulated in a different system !!!
Molecular Cell@MolecularCell19 Apr 2023
Online Now: INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II dlvr.it/Sml3jr

INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase...

Hu et al. reveal that the two catalytic modules of INTAC have unexpectedly general yet distinct roles in transcription: the endonuclease module cleaves nascent RNAs to induce promoter-proximal RNA...

cell.com
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Apoorva Baluapuri retweeted
Claudia Mimoso@camimoso24 Mar 2023
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…
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Molecular Cell@MolecularCell3 Feb 2023
Integrator is a global promoter-proximal termination complex dlvr.it/Shtx7G
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New therapies for a certain type of #pancreatic #cancer: Elmar Wolf @Uni_WUE is working on this. He has now received a €2 million ERC Consolidator Grant from the EU. Congratulations! #ERCCoG @_WolfLab @ERC_Research go.uniwue.de/wolf-erc
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Another day, another #NRMCBResearchHighlight! 🥳 We highlight work by Elmar Wolf' and Martin Eilers's labs @Uni_WUE, recently published @Nature: go.nature.com/3uIsfb7
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