Adelman Lab at Harvard Medical School, BCMP Department
Boston, MA
Joined August 2018
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AdelmanLab retweeted
Congratulations to Karen Adelman, Edward S. Harkness Professor of @HMS_BCMP, for her election as an @EMBO Associate Member! @harvardmed @AdelmanLab
Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community
embo.org/press-releases/outs…
AdelmanLab retweeted
I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors!
biorxiv.org/content/10.1101/…
Congratulations Emily and all authors! It’s great to see such a clear role for NELF-mediated RNAPII pausing in spermatogenesis. Thanks to Prabu for introducing us to this cool system!
Happy to announce the final version of our paper is now available @NatureComms!
nature.com/articles/s41467-0…
Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
Congratulations to all for a great team effort! Thanks especially to Zuzana, Emily Wheeler and Ben Martin for their exceptional contributions!
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AdelmanLab retweeted
SWI/SNF function compensated by another chromatin remodeller go.nature.com/3RkTG7m #ResearchHighlight by @haertl17
Thanks @Ludwig_Cancer for highlighting our work! @bmart87
A team led by Ludwig Harvard’s Karen @AdelmanLab has discovered why drugs targeting SWI/SNF, a protein complex that's mutated in 20-25% of cancers, don't always work as expected—and shown in cell culture studies how such resistance might be overcome. bit.ly/3QWrI1z
AdelmanLab retweeted
We have a great lineup of speakers for the the @CEEHRC annual meeting, featuring 2 exciting keynotes this year.
Michael Taylor from @TexasChildrens
@bcmhouston
Karen Adelman @AdelmanLab from @harvardmed who is our Trainee Keynote for this year!
event.fourwaves.com/ceehrc20…
Such great news! Congratulations to two amazing scientists, Eva Nogales @NogalesLab and Patrick Cramer @CramerLab who have changed our understanding of transcription with their beautiful structures! 🎉
The #ShawPrize in #LifeScienceAndMedicine 2023 is awarded in equal shares to Patrick Cramer and Eva Nogales for pioneering structural biology that enabled visualization, at the level of individual atoms, of the protein machines responsible for #genetranscription.
#ShawPrize2023
Thanks Rab! It was awesome to see you. It’s always inspirational to talk science with you, and a nice glass of port never hurts! 😉
Managed to catch-up with the truly amazing Karen Adelman @AdelmanLab before leaving Boston for Philadelphia. So much science, family and football to discuss. With perhaps a cheeky glass of port.
Thank you! We are definitely excited and hopeful about the prospects!
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AdelmanLab retweeted
And there is a nice perspective article by Robert Fisher here: science.org/doi/10.1126/scie…
AdelmanLab retweeted
Great to see the conclusions from a recent paper from our lab (Stein et al 10.1016/j.molcel.2022.10.004) so nicely recapitulated in a different system !!!
Online Now: INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II dlvr.it/Sml3jr
AdelmanLab retweeted
Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences! @AdelmanLab @harvardmed
Congratulations to our new members! Just announced! We are honoring the excellence of extraordinary leaders in an array of disciplines and professions. The first members were elected in 1781. Learn who was elected in 2023: amacad.org/news/2023-member-…
AdelmanLab retweeted
Pedal to the metal--U1 snRNP, known to be important for mRNA splicing, stimulates the elongation rate of RNA polymerase II (RNAPII). This allows RNAPII to transcribe introns more quickly, reducing the chance of transcriptional arrest. @camimoso @AdelmanLab
ow.ly/R2m750NvR3E
Congratulations Redi!
Very happy to have been awarded the NSF GRFP. This would not have been possible without the people who provided help and training along the way. Many thanks to everyone, especially Karen @AdelmanLab, Danesh @Moazed_Lab and Craig @craigedit.
AdelmanLab retweeted
with U1 snRNP bound
pol2 elongates faster
and with fewer stops
#ChromatinHaiku
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…
AdelmanLab retweeted
Online Now: U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes dlvr.it/SlQPQQ
Huge congratulations and thanks to Claudia @camimoso who single handedly did all the experiments and analysis in this paper. I’m so impressed and proud!
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…