@zhulinlab

Igor Jouline's computational biology lab. Signal transduction - Evolution - Disease

 Columbus, OH
biology.joulinelab.org/
Joined April 2014
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We're excited to introduce the GPCR Evolution Database - an open-access resource for evolutionary analysis of GPCRs 🎉 👉 gpcrevolution.org 📄 doi.org/10.64898/2026.09.08.… 🧵
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NIH grant training video: “The review process can be discussed with no one. This includes your lab members, colleagues…”Me trying to figure out if everyone else is fair game since they just defined "no one" as a specific list: 👁️👄👁️
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New paper! How do hundreds of GPCRs maintain the same activation mechanism while evolving to recognize completely different signaling partners? We developed an evolutionary framework that separates residues responsible for shared GPCR functions from those driving specialization
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A ligand-binding sensor domain got a tiny insertion from cytochrome c, which contained a heme-binding motif, and now it is a nitric oxide sensor. As simple as that: biorxiv.org/content/10.64898…
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A really cool platform for annotating new bacterial genomes and metagenomes. Intuitive, biologist-friendly interface and a powerful gene neighborhood tool. So, if you have a new (meta)genome - don't go anywhere else. It's free (I don't know why -)) - seqhub.org
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What are the odds? Two PNAS acceptances, 28 minutes apart. Maybe I should start buying lottery tickets?
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We keep learning new things about bacterial flagella: biorxiv.org/content/10.1101/…

FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type...

The bacterial flagellum is a complex nanomachine essential for motility, environmental sensing, and host colonization. While many of its core components have been well characterized, the relevance of...

biorxiv.org
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ChatGPT says: The two spellings Zhulin and Jouline are both transliterations of the same original Russian surname Жулин — but they follow different conventions: Zhulin - Anglo-style transliteration, JoulineFrench-style transliteration. Are we clear now :-)?
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Our last review now out in Trends In Microbiology: Structural and functional diversity of sensor domains in bacterial transmembrane receptors @BLASTMeetings @SEMicrobiologia @miguel_matilla @gavirius @Eli_Monteagudo @zhulinlab sciencedirect.com/science/ar…
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Cache-containing chemoreceptors by AlphaFold. One is sober, another is drunk as a skunk. Managed to cross the membrane twice. "How many ligands did you have, Dude?"
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Our heartfelt thanks to our reviewers, authors, readers, and followers. In 2024, we achieved over 1.075 million full reads and published 227 articles. This incredible milestone wouldn’t have been possible without your continued support.
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Interested in anti-bacteriophage defense systems? We have an open PhD position in cell biology of bacteria and bacteriophages: nature.com/naturecareers/job…
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Not only a beautiful image and a beautiful structure, but also an example of a tour de force that can be achieved when two talented assistant professors join forces!
ZackB
@zacharyberndsen20 Feb 2025
Our ApoB paper is out in print today in @Nature and since we didn't get the cover I can share our (@CKeithCassidy ) beautiful artwork from molgraphics.com/ that wasn't selected 😆 rdcu.be/eaGPH
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Zhulin Lab retweeted
SourjikLab@sourjik18 Feb 2025
Just appeared: How knowing physics helps to understand bacterial strategies of resource allocation. Congratulation @LisevichIra on this paper! nature.com/articles/s41467-0…
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Phosphorylated CheV interacts with a subset of chemoreceptors biorxiv.org/content/10.1101/… #biorxiv_micrbio

Phosphorylated CheV interacts with a subset of chemoreceptors

Chemotaxis pathways are among the most complex signaling systems in bacteria. A central feature of these pathways is the ternary complex formed by chemoreceptors, the autokinase CheA, and the...

biorxiv.org
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Usually, things evolve from simple to complex, but occasionally they say "Well, wait a minute, let's go back to where we were..." pnas.org/doi/10.1073/pnas.24…
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The Institut Pasteur is leaving X. Due to serious issues observed since its acquisition by Elon Musk, the Institut Pasteur is suspending its activities on this platform starting today and invites its followers to join on other platforms. ➡️ linktr.ee/institutpasteur
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The recent COG update paper, now with page numbers: academic.oup.com/nar/article…

COG database update 2024

Abstract. The Clusters of Orthologous Genes (COG) database, originally created in 1997, has been updated to reflect the constantly growing collection of co

academic.oup.com
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A really cool concise review by @EmonetLab looking at bacterial chemotaxis from the physicist's point of view: cell.com/current-biology/ful…
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It was a delight to give a talk at this amazing amphitheater during #IUMS2024, especially after the inspiring keynote lecture by @ACasadevall1 . Thank you @IUMSmicrobio for the invitation! Glad to represent @ASMicrobiology at this global forum.
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