@wjunj

Microbiologist at NEA, Environment Health Institute, Microbiology and Molecular Epidemiology Division

 singapore
Joined September 2010
  • Tweets331
  • Following366
  • Followers146
6Media
Monitoring pathogens in wastewater nature.com/articles/s41579-0… Wastewater genomic surveillance can transform global viral disease monitoring. This Genome Watch article explores the techniques, analytical pipelines and implications for public health.
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The most recent work of my post-doc at SMART, in the Chen (MIT) and Kline (Unige) Labs is out! science.org/doi/10.1126/scia… Curious about how we can use repurposed compounds to target macrophages to clear infections? See the link for the article with our most recent example. 🧵👇🏻

Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus...

Mitoxantrone represents a promising dual bacterium- and host-targeted therapeutic for overcoming vancomycin resistance.

science.org
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E. coli senses S. aureus and upregulates colibactin production, which kills >99.99% of coinfecting Staph during wound coinfection. @wjunj @JchenLab @KimInGeneva plos.io/3BuQOg6

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin...

Author summary Wound infections are often polymicrobial in nature and are associated with poor disease prognoses. Escherichia coli and Staphylococcus aureus are among the top five most cultured...

journals.plos.org
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Excited to share our latest work on polymicrobial wound infections, led by @wjunj, now out in @plospathogens: journals.plos.org/plospathog… #WhatNoEnterococcus

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin...

Author summary Wound infections are often polymicrobial in nature and are associated with poor disease prognoses. Escherichia coli and Staphylococcus aureus are among the top five most cultured...

journals.plos.org
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Three days to go to apply for an exciting postdoc position to join our friendly team and work on inter-bacterial interactions mediated by the T6SS and its effectors. Closing date 02 Feb, details here: bit.ly/3tYY0xP
Sarah Coulthurst@SarahCoulthurs124 Jan 2022
Do you want to live in beautiful Scotland and work on T6SS effectors? Do you want to join (or remain in) the vibrant UK Microbiology community @MicrobioSoc? Do you have expertise in applying next-gen sequencing or bacterial cell biology? Postdoc available: bit.ly/3tYY0xP
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We are recruiting for a post-doc to join an exciting project studying the role and molecular basis of inter-bacterial interactions mediated by the bacterial Type VI secretion system. We are a friendly lab in the world-class @UoDLifeSciences bit.ly/3Gakr67 Pls retweet!
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Wong Jun Jie retweeted
Shu-Sin Chng@Figlegend31 May 2021
Super excited abt our latest work, where we reconstituted lipid transfer & gained insights into the MlaFEDB complex, an ABC transporter in the OmpC-Mla system impt for bacterial OM lipid asymmetry. Massive work by Wen-Yi Low, supported by Shuhua Thong! biorxiv.org/content/10.1101/… 1/8

ATP disrupts lipid binding equilibrium to drive retrograde transport critical for bacterial outer...

The hallmark of the Gram-negative bacterial envelope is the presence of the outer membrane (OM). The OM is asymmetric, comprising lipopolysaccharides (LPS) in the outer leaflet and phospholipids...

biorxiv.org
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The human virome: assembly, composition and host interactions rdcu.be/chLEA Liang and Bushman review research on the human virome and highlight studies that explore the assembly and composition of the virome as well as host–virome interactions in health and disease.
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Pfizer Inc.
@pfizer9 Nov 2020
UPDATE: We are proud to announce, along with @BioNTech_Group, that our mRNA-based #vaccine candidate has, at an interim analysis, demonstrated initial evidence of efficacy against #COVID19 in participants without prior evidence of SARS-CoV-2 infection.

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Type X secretion anyone? doi.org/10.1111/mmi.14599
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Wong Jun Jie retweeted
NTU Singapore
@NTUsg6 Aug 2020
A synthetic #peptide molecule developed by @NTUsg scientists makes drug-resistant bacteria vulnerable to antibiotics again. In combination with conventional antibiotics, it could be an effective treatment for antibiotic-tolerant infections. bit.ly/SuperbugPeptide @SCELSE_SG
A synthetic peptide molecule developed by scientists makes drug-resistant bacteria vulnerable to antibiotics

ALT A synthetic peptide molecule developed by scientists makes drug-resistant bacteria vulnerable to antibiotics

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The T6SS makes the cover @JBacteriology Congrats to the SciArtist Annalisa Pierro @Annalekos ! jb.asm.org/content/202/13.co…
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T6SS: shoot and scrub This study shows that T6SS-mediated killing of competitors is most effective if a lytic toxin is injected. nature.com/articles/s41579-0…
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science.sciencemag.org/conte…
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Targeted microbiome depletion This study describes the development of an approach to selectively target and deplete cells in complex microbial communities. nature.com/articles/s41579-0…
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Wong Jun Jie retweeted
Swaine Chen@swaine_chen11 May 2020
Honored and excited to be invited to write together with @NUSMedicine Dean Chong Yap Seng! Our first op-ed together, taking a step back on #COVID19 and looking to the (hopefully near) future! newenglanddiary.com/home/6vi… @NewEnglandDiary
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UPECpapers@UPECpapers27 Mar 2020
Tailoring a Global Iron Regulon to a Uropathogen. dlvr.it/RShRsK

Tailoring a Global Iron Regulon to a Uropathogen - PubMed

Pathogenicity islands and plasmids bear genes for pathogenesis of various Escherichia coli pathotypes. Although there is a basic understanding of the contribution of these virulence factors to...

pubmed.ncbi.nlm.nih.gov
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Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWAB USING QIAGEN RNEASY KITS OR DIRECTLY VIA OMISSION OF AN RNA ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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