Cellular immunologist exploring the complex interactions of immune cells and microbiota in skin.
University of Pennsylvania
Joined October 2021
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Tej Pratap Singh retweeted
Barriers sites are characterized by complex immunological crosstalk between pathogens, commensals, and the immune system. Explore this collection highlighting recent JEM papers dissecting barrier immunity at the epithelial and neurovascular barriers. ➡️ hubs.la/Q02kSy9_0
Tej Pratap Singh retweeted
.@tpsinglab et al. reveal that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology hubs.la/Q02kSFC90
In our Barrier Immunity collection: hubs.la/Q02kSy4j0
#KSBarrierReg24
Tej Pratap Singh retweeted
How do systemic PAMPs become accessible to cytosolic PRRs in vivo? Thrilled to have our work out @NatureCellBio showing Host EVs capture and escort systemic LPS to cytosol activating Casp11 & pyroptosis. Congrats to Puja @dolly_puja, who led the work. 1/3 nature.com/articles/s41556-0…
Tej Pratap Singh retweeted
A great mentor, a great scientist, a great human being, the best person for this position at Pasteur. We miss you at @NIH already!
La Professeure Yasmine Belkaid prend ses fonctions en tant que Directrice Générale de l'Institut Pasteur ↘️pasteur.fr/fr/espace-presse/…
ALT L'Institut Pasteur annonce l'entrée en fonction de la Professeure Yasmine Belkaid en tant que nouvelle Directrice Générale depuis le 2 janvier 2024. Sa nomination, approuvée par le Conseil d'administration le 29 mars 2023, marque le début d'un mandat de 6 ans à la tête de l'institution. ©Institut Pasteur / François Gardy
Intestinal inflammation is driven by unrestrained activation of IFNγ-producing CD4+ T cells and depletion of peripherally induced regulatory T cells through Fcγ receptor signaling.
#MicrobiotaPower! Anti-tumor checkpoint blockade therapy can lead to #colitis, Nunez &co show @ScienceMagazine that this happens in mice that harbor microbiota of wildlings. Colitis is driven by FcgR that depletes Tregs & boosts IFNg production by T cells! science.org/doi/10.1126/scie…
Tej Pratap Singh retweeted
Fantastic @Nature by Nir Hacohen &co! They created gene transcription maps at the single cell level for 17 different cell types in the lymph node in response to each of the 86 cytokines & develop a tool to infer from RNAseq data cytokine activity! nature.com/articles/s41586-0…
Tej Pratap Singh retweeted
Being a mid-career professor is different in a lot of ways from being junior faculty. I worry we are not providing them with the support they need to grow in their jobs, potentially squandering the talent we invested decades in nurturing. (Not just funding.)
We highlight how the human microbiome can shape disease outcomes in cutaneous leishmaniasis and suggest pathways toward host-directed therapies to mitigate the inflammatory consequences. Nice work @amorim_cfa @microbiome @RNAseq @immunology
science.org/doi/10.1126/scit…
Tej Pratap Singh retweeted
Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
Tej Pratap Singh retweeted
Using Foxp3+ Treg cell counts, we categorized patients in a skin #RNAseq dataset. In Leishmania+S.aureus co-infection cases, low Foxp3+ Treg levels connect to harmful IFN-g #inflammation and slower healing, unveiling its dual role in infections. #NGS #datawrangling #translational – at Philadelphia, PA
Study by Singh, Scott et al. @PennMedicine involving mice and #Leishmania braziliensis patients reveals that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology. bit.ly/3MgOlen
The editorial is out now; thanks to all the authors for their contributions:
frontiersin.org/articles/10.…
Researchers back African Union to join G20 group of largest economic powers nature.com/articles/d41586-0…
Enjoyed editing the review article by Richard L. Gallo
frontiersin.org/articles/10.…
@UCSDMedSchool @dermatology @microbiota
Tej Pratap Singh retweeted
Colonic RORγ+ Treg cells seed non-mucosal tissues in response to injury wherein they can rein in IL-17A-driven inflammation, regulate stem cell activities, and promote tissue regeneration @ImmunityCP @bolahanna MathisLab
cell.com/immunity/fulltext/S…
A journey from work to home is about more than just getting there – the psychological benefits of commuting that remote work doesn't provide theconversation.com/a-journe… via @ConversationUS
Tej Pratap Singh retweeted
Admissions tip - we’re not primarily selecting candidates based on “merit.” We’re selecting based on “how likely are they to successfully complete our program.” That is our primary concern, student success. Apply accordingly.
Old but still gold in my heart: UVR as a treatment for psoriasis and crucial role for Foxp3 Treg cells @PennSbdrc @pennvet
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ reg… pubmed.ncbi.nlm.nih.gov/2048…
Tej Pratap Singh retweeted
We are happy to release these new human reference single-cell maps for #ProjecTILs
