@pscottlab

We are a lab at University of Pennsylvania @pennvet investigating host-pathogen interactions.

 Philadelphia, PA
Joined November 2019
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  • Following76
  • Followers760
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Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity science.org/doi/10.1126/scit… – at Chicago, IL

Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms...

The skin microbiome enhances pathology through IL-1β and delays healing in cutaneous leishmaniasis patients.

science.org
Camila Farias Amorim, Ph.D@amorim_cfa19 Oct 2023
A #translational study evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in a parasitic infection, cutaneous #leishmaniasis. @hostmicrobe @tpsinglab @novaislab @LovinsTori @pscottlab @HarrisOnTheSkin #eGrice science.org/doi/10.1126/scit…

Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms...

The skin microbiome enhances pathology through IL-1β and delays healing in cutaneous leishmaniasis patients.

science.org
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Come to work in a GREAT multidisciplinary team @Penn super interested in Host-Pathogen interactions and cutting-edge high-throughput NGS single-cell technologies #JobAlert #Bioinformatician💻🐛🧫 – at Philadelphia, PA
Daniel Beiting@hostmicrobe23 Dec 2023
Start your New Year with a new job! We're hiring a bioinformatics specialist to lead analyses of single cell genomic data 💻. Great opp. to work w/ a large and interdisciplinary team of immunologists and infectious disease researchers. Apply below! bit.ly/3GUY9Hz
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Start your New Year with a new job! We're hiring a bioinformatics specialist to lead analyses of single cell genomic data 💻. Great opp. to work w/ a large and interdisciplinary team of immunologists and infectious disease researchers. Apply below! bit.ly/3GUY9Hz
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Findings by @tpsinglab @pscottlab and colleagues @pennvet @PennMedicine have clinical ramifications for cutaneous leishmaniasis and other skin diseases associated with a dysregulated microbiome when Tregs are limited or dysfunctional. bit.ly/3MgOlen #InfectiousDisease
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Insights: Michail Lionakis @LionakisLab @NIAIDNews discusses study from @tpsinglab, @pscottlab et al. (bit.ly/3MgOlen) showing that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth: bit.ly/48Y7iMy
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Learned more about S. aureus as editor of this excellent review @WolfDermGraz @PennSbdrc @pscottlab Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis frontiersin.org/articles/10.…

Frontiers | Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. A disrupted skin barrier, type...

frontiersin.org
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This cover is amazing! Our recent publication is here! Evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in cutaneous #leishmaniasis – at Chicago, IL
Science Translational Medicine@ScienceTM18 Oct 2023
The new special issue on zoonotic diseases has arrived! Articles this week explore the latest research and counterstrategies for zoonotic threats, including an Editorial from Anthony Fauci and research on how the skin microbiome influences leishmaniasis. scim.ag/4vr
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We highlight how the human microbiome can shape disease outcomes in cutaneous leishmaniasis and suggest pathways toward host-directed therapies to mitigate the inflammatory consequences. Nice work @amorim_cfa @microbiome @RNAseq @immunology science.org/doi/10.1126/scit…
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Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis, say Tej Pratap Singh @tpsinglab, Phillip Scott @pscottlab and colleagues @pennvet @PennMedicine: bit.ly/3MgOlen #InfectiousDisease #HostDefense
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Tregs tame skin bacteria and IFN-γ-associated pathology. Michail Lionakis @LionakisLab @NIAIDNews discusses recent study from @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) in new Insights: bit.ly/48Y7iMy #InfectiousDisease #HostDefense #Tolerance
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A #translational study evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in a parasitic infection, cutaneous #leishmaniasis. @hostmicrobe @tpsinglab @novaislab @LovinsTori @pscottlab @HarrisOnTheSkin #eGrice science.org/doi/10.1126/scit… – at Chicago, IL

Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms...

The skin microbiome enhances pathology through IL-1β and delays healing in cutaneous leishmaniasis patients.

science.org
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Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
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Insights @JExpMed by @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
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We appreciate immensely the @LionakisLab, for your insights on our recent work showing that Foxp3+ Rorγt+ Tregs suppress pathogenic IFN-γ responses to control S. aureus growth @tpsinglab @pscottlab #eGrice – at Philadelphia, PA
Journal of Experimental Medicine@JExpMed10 Oct 2023
Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (bit.ly/3MgOlen) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth bit.ly/48Y7iMy
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Led by @tpsinglab, collab with @amorim_cfa, @LovinsTori , Charles Bradley, Carvalhos labs and Elizabeth Grice 🧫 #translationalresearch #infectiousdiseases #inflammation #immunology #Tcell #bacteria #parasite #omics #DualRNAseq #datascience #datamodeling #clinicaloutcome – at Philadelphia, PA
Journal of Experimental Medicine@JExpMed9 Oct 2023
Study by Singh, Scott et al. @PennMedicine involving mice and #Leishmania braziliensis patients reveals that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology. bit.ly/3MgOlen
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Looking to study parasites for your PhD training? Join us a Penn! Great breadth cell biology, genomics, immunity, drug and vaccine development. Great labs & environment! @KingOfPathogens @yiweichang @odomjohnlab @DeBroski1 @hostmicrobe @PoveLab @omartheharb @pscottlab @dsro5os
Penn BGS@pennbgs2 Oct 2023
We are pleased to announce that we are now accepting BGS applications for Fall 2024 until December 1st! Please see our Admissions page for more info and how to apply: med.upenn.edu/bgs/phd-applic…
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Leishmania braziliensis patients & mouse models reveal that Treg levels function as a rheostat, controlling bacteria in the skin and influencing whether bacteria induce IL-17 or IFN-γ–mediated immunopathology @JExpMed @pscottlab doi.org/10.1084/jem.20230558

Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis

Foxp3+ regulatory T cells are vital for skin homeostasis, and this research involving mice and Leishmania braziliensis patients reveals that Treg levels fu

rupress.org
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⁦ok @CytokineSociety⁩ members ⁦@ImmunologyAAI⁩ stop by booth and learn about the annual meeting in Athens
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A great meeting for our family of immuno•parasitologists at the Woods Hole Conf 2023 🦠🪱 I got awards for our current study! @novaislab @pscottlab #DrAlanSher @MBLBoP @tpsinglab @LovinsTori #DrElizabethGrice @WHIP42266646 #Immunology #parasites #microbiome #science
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Being Dr. Alan Sher's scientific granddaughter is a real privilege and honor. Today I had the opportunity to hear again what I've been learning from @pscottlab over the years: "The parasites teach us a lot about immunology." at @MBLScience @MBLBoP @WHIP42266646
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