Physician-scientist #NIAID @NIH | #Immunology | #innate immunity | #Immunodeficiency | #Fungi | #Infection | Father | 🇬🇷🇺🇸 | Views are mine, not of US govt
Bethesda, MD, USA
Joined January 2021
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We previously showed that APS-1/APECED features excess IFNg responses that can be targeted therapeutically (Oikonomou NEJM 2024). We now extend this to show that early JAK inhibition can intercept the development of irreversible autoimmune endocrinopathies
nature.com/articles/s41467-0…
Expanded diagnostic criteria in APECED promote earlier diagnosis which can improve patient outcomes
insight.jci.org/articles/vie…
pubmed.ncbi.nlm.nih.gov/4248…
@JCI_insight
In @elife: Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency doi.org/10.7554/eLife.111039…
Great work, Kathleen! Many congratulations!
A million thanks to @tmhohl71, the whole Hohl lab 🍄, @LionakisLab, Amariliz Rivera's group @RutgersU, @WCM_IMP, and the folks @SciImmunology. If you'd like to read the paper 📰 and don't have access for any reason, I'm happy to send a copy, just let me know. End thread ☺️
A great lab to train! Amazing science, great mentoring!
Interested in immunology and looking to gain research experience before applying to graduate or medical school?Join us! We're hiring a research technician general-mskcc.icims.com/jobs…
Mihalis Lionakis retweeted
𝘊. 𝘢𝘶𝘳𝘪𝘴, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health care facilities. Full review with interactive map: nej.md/3CMj8gT
ALT Figure 1. Geographic Origins of Candida auris and Clinical Cases in the United States. Shown are the areas of the globe in which the five C. auris clades initially arose. The inset shows the number of C. auris clinical cases across the United States from 2013 through 2022 (data are from www.cdc.gov/fungal/candida-auris/tracking-c-auris.html). In South Africa and India, C. auris accounts for up to 25% and 40% of candidemia cases, respectively, in certain health care settings.
Fun to write this review on Candida auris infections @NEJM with @AnuradhaMyco! Thanks Anu!
nejm.org/doi/full/10.1056/NE…
Mihalis Lionakis retweeted
Our recent study out today in @PLOSPathogens identified cell type specific immune responses to Candida auris skin infection using single cell transcriptomics. Thank you @LionakisLab, Mihai Netea and Vinod for collaborating in this study !
journals.plos.org/plospathog…
Thanks @NIAIDNews for highlighting our work!
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Our synthesis of the genetics, immunopathogenesis, diagnosis, and treatment of inborn errors of immunity that impair thymic development and/or function. With Francesca Pala and Gigi Notarangelo @jacionline
sciencedirect.com/science/ar…
Mihalis Lionakis retweeted
Candida auris
Skin tropism
Drug resistance
Challenging infection control
Persistence at hight temperatures and high saline condition
#IDWeek2024 Dr. Lionakis
Mihalis Lionakis retweeted
We are recruiting! A PhD position is available @LabLeibundgut on Malassezia-host interactions. We are looking for highly motivated, creative and dedicated team player. Please apply before 1st November via our PhD program @MimZurich at mim.ethz.ch/application/appl…
Mihalis Lionakis retweeted
Host-microbe interaction paradigms in acute &recurrent vulvovaginal candidiasis
@jessiemacalpine @LionakisLab review host, microbiome &fungal factors that alter susceptibility to vaginal yeast infections & highlight progress in antifungals & vaccination
cell.com/cell-host-microbe/a…
Mihalis Lionakis retweeted
Reviews on Fungi
Host-microbe interaction paradigms in acute & recurrent vulvovaginal candidiasis
cell.com/cell-host-microbe/a…
Intestinal fungal-host interactions in promoting &maintaining health
cell.com/cell-host-microbe/f…
Immunity to fungi &vaccine considerations
cell.com/cell-host-microbe/f…
A synthesis of our current understanding of host-fungal interactions in vaginal candidiasis, the most common human fungal infection. By @jessiemacalpine, way to start your fellowship at @NIAIDNews Jessie! @cellhostmicrobe
sciencedirect.com/science/ar…
An honor to write a @J_Immunol Pillars piece for @slg1717 and H.Conti groundbreaking work @JExpMed on IL-17 promoting mucosal fungal defense. A rare example of basic research that faithfully translates to humans and will undoubtedly stand the test of time! pubmed.ncbi.nlm.nih.gov/3937…
Mihalis Lionakis retweeted
Last call: ID Service @MSKCancerCenter is hiring a clinician. Interest in stewardship a plus, not required. Apply via: careers.mskcc.org/vacancies/…
Include CV, cover letter, career statement, and contact info for 3 references. Applications reviewed as they come in through October.
Mihalis Lionakis retweeted
Focus on Fungi: from infections to immunity, inflammation, mycobiota, and AMR with the amazing @slg1717 @gordon_d_brown @DukeHeitman @LionakisLab, Bruce Klein, Petra Bacher. #FungaWeek24 @Cell cell.com/cell/fulltext/S0092…
1/3 Excited to share our new paper led by Sebastian Ochoa & @ChasenLouie at @ScienceTM in which we found a deep intronic AIRE variant that causes inclusion of a frame-shifting pseudoexon that impairs AIRE function and explains APECED in ~15% of our cohort science.org/doi/10.1126/scit…
3/3 an antisense oligonucleotide could restore normal AIRE splicing in vitro, pointing to a potential treatment approach for these patients (currently being tested in a new KI mouse model with this variant). Thanks to all referring physicians and to collaborators @AfzaliBehdad