NK cells; neutrophils; cytokines; cancer; inflammatory diseases etc |@sahlgrenskaAcad | @goteborgsuni
Göteborg, Sverige
Joined November 2015
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We are hiring!
Join our great team as a PhD student to develop future’s NK cell-based immunotherapy! Fully funded 4-year position available at Sahlgrenska Center for Cancer Research in Gothenburg.
Apply before Feb 27, or please spread in your network! gu.se/en/work-at-the-univers…
Thorén lab retweeted
Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell/full…
extensive 15-post-🧵 below
Dissertation day @goteborgsuni @SahlgrenskaAcad.
Excellent performances by @LinneaKristensn and faculty opponent @MalmbergLab. 🥂🥳🍾 #nkcells #crispr
It is out in PNAS!
A new study, led by @LinneaKristensn from us demonstrates that loss of function mutations in TMEM30a enable escape from NK cell cytotoxicity.
pnas.org/doi/10.1073/pnas.23…
A thread...
The NK-resistant phenotype of TMEM30a-deficient cells was not specific for K562 cells. Several leukemia and lymphoma cell lines displayed elevated PtdSer levels and reduced sensitivity to NK cells after deletion of the TMEM30A gene.
TMEM30a mutations are recurrently found in lymphoma, and our study thus suggests that this may be an NK cell-evasive strategy in these malignancies. Thanks to co-authors @chiarabadami256 @BrwaAliHussein @group_tang @YarongTian @FbThoren and others not on X/Twitter
Great performance by @hana_komic today when she defended her PhD thesis! Thanks to faculty opponent @BjornTG
Celebration day in the lab! @hana_komic nailing her thesis before the dissertation on Feb 29th. @goteborgsuni @SahlgrenskaAcad @sahlgrenska
Thorén lab retweeted
Interested in single cell sequencing and have a passion for cancer or mucosal immunology? Come join our lab! A great opportunity to grow your career as a postdoc: ki.varbi.com/what:job/jobID:…
Today on World #CML day, we are happy to present our latest preprint on leukemic stem cells #LSC. For the first time, we combine CITEseq with concomitant BCR-ABL1 detection. Great collaboration with @Martnerlab @MalinNilsson__ @hana_komic biorxiv.org/content/10.1101/…
Thorén lab retweeted
Thrilled to see our latest work @thoren_lab is published!
We reported biological/clinical impact of NKG2A rs1983526 jitc.bmj.com/content/11/8/e0…
Grateful to all co-authors for their help and input!
Thank you to the editor/reviewers & the rest of #JITC team for their efforts!
New #JITC article: NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells bit.ly/45wMY2r @thoren_lab @BrwaAliHussein
Thorén lab retweeted
New #JITC article: NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells bit.ly/45wMY2r @thoren_lab @BrwaAliHussein
Thorén lab retweeted
How did Sweden fare during the pandemic? Back then, the world was shocked by our openness. New York Times called us a “cautionary tale”, Trump said “Sweden is suffering very greatly”. But we never heard how it all turned out.
Now I’ve looked: Sweden did better than others. 🧵
Thorén lab retweeted
HLA-B*44 and the Bw4-80T motif are associated with poor outcome of relapse-preventive immunotherapy in acute myeloid leukemia: link.springer.com/article/10… #AML #CancerImmunotherapy #NKCellTherapy
Happy to see this paper out in CII, a project started by @Hallner90 and finalized by @hana_komic. Full text here, rdcu.be/djVLj
@SahlgrenskaAcad @goteborgsuni
A short 🧵...
The association w inferior survival was not shared across the HLA-B44 supertype, which comprises HLA-B alleles that present similar peptides. But interestingly, HLA-B*44 harbors an 80T-Bw4 motif – a weak ligand to the NK receptor KIR3DL1.
We found that individuals with this weak 80T-Bw4 ligand had less functional NK cells and inferior survival after HDC/IL-2 immunotherapy in AML.
Thanks to all involved, @elinbernson @BrwaAliHussein @chiarabadami256 and others not on Tw/X