@tcppham

Postdoc @BiomedUCPH studying #Exercise #Muscle #Mitochondria

Joined January 2015
  • Tweets47
  • Following98
  • Followers120
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The mighty mitochondria strike again!💪⚡️So excited to share our latest paper on exercise and mitochondrial adaptations. Endless gratitude to our fantastic collaborators and funders for their support!
Lykke Sylow@LykkeSylow
14 Nov 2024
In our latest study led by @tcppham, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! nature.com/articles/s41467-0…

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure...

Nature Communications - Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise...

nature.com
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Replying to @Dpla_ @LykkeSylow
Thank you, David!
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Lykke Sylow@LykkeSylow
3 Jun 2024
In this work, driven by amazing postdoc in our team @A_Irazoki, we found that adaptations to cancer in mice critically depend on housing temperature. biorxiv.org/content/10.1101/…

Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice

Cancer cachexia is a metabolic condition affecting up to 80% of patients with cancer. Cachexia is mediated by reduced muscle and fat mass and impaired function, and it lowers survival for patients....

biorxiv.org
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Replying to @BarteltLab
Any chance for non-Bavarians to participate?🙏
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Replying to @TimoMueller_IDO @AaronNovikoff @helmholtz_diabc
Of course he did! Congratulations, Aaron! 🥳 And hi Timo :)
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Camilla Lund@CamillaLund92
9 Feb 2024
Exciting news! My main paper for my PhD in the @ClemmensenC lab with @pranea is now published in @naturecomms! 🎉 It delves into how the body is naturally defended against excessive weight gain. A🧵👇#obesityresearch 1/11 nature.com/articles/s41467-0…

Protection against overfeeding-induced weight gain is preserved in obesity but does not require...

Nature Communications - Overfeeding triggers a mechanistically ill-defined compensatory response that counteracts weight gain. Here, the authors show that the defence against overfeeding is...

nature.com
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Thomas E. Jensen@tejensen23
16 Jan 2024
2y research assistant position (master degree or equivalent) on international collaborative project with me and Christine Allen, Toronto, to test temperature-sensitive liposomes for muscle drug-targeting in mice🐀. Please help me spread the word 🙏 jobportal.ku.dk/videnskabeli…
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Excited to share our latest work on the dynamic relationship between mitochondria and exercise! 🏋‍♀️ Dive into the details and share your thoughts in the thread below.🙏
Lykke Sylow@LykkeSylow
14 Jan 2024
Just submitted our manuscript🤞 We uncover the exercise-responsive mitochondrial-mRNA-stabilizing protein SLIRP, as a PGC-1α target that regulates mitochondrial structure, respiration, and mitochondrially-encoded-mRNA pools in skeletal muscle. Preprint: biorxiv.org/content/10.1101/…

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial struct...

The decline in mitochondrial function is associated with decreased muscle mass and strength in multiple conditions, including sarcopenia, type 2 diabetes, and cancer. Treatment of these diseases...

biorxiv.org
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Steffen H. Raun@SteffenRaun
10 Jan 2024
A fun little read about the discovery of GLUT4 more than 30 years ago 😃 @NatureRevEndo @UCPH_health
Nature Reviews Endocrinology@NatureRevEndo
9 Jan 2024
Journal club: Steffen H. Raun highlights two seminal papers from 1988 and 1989 that describe what is now known as glucose transporter 4 (£) go.nature.com/3tOgBPq
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Replying to @AaronNovikoff
Major pinch-me moment! Thank you, Aaron!
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Happy #FluorescenceFriday! @ed_battey working some Christmas magic on our mouse muscle samples. Stunning piece of art! 🎄🔬 #myotwitter
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Replying to @HeWaHippo
Any chance this could be a hybrid meeting? :)
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Replying to @magnusgronset @NEXSKU
Thank you, Magnus :)
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Replying to @ThibauxV @NEXSKU
Thank youuuu :)
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Replying to @hohien @NEXSKU
Thank you, Hien😊
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Replying to @AaronNovikoff @LykkeSylow
Thank you, Aaron! :)
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A new page in obesity research: Thrilled to share our latest publication uncovering a new regulator! Thank you to everyone who's been part of this journey.🙏 @NEXSKU @BiomedUCPH
Lykke Sylow@LykkeSylow
10 Aug 2023
In this study, driven by @tcppham🔥we integrated diet-induced obesity Drosophila and mouse models, metabolomics studies, and a multitude of metabolic screening approaches and identify TNIK as a conserved regulator of glucose and lipid metabolism in obesity science.org/doi/10.1126/scia…

TNIK is a conserved regulator of glucose and lipid metabolism in obesity

Cross-species comparative analysis identifies TNIK as a crucial component of whole-body glucose and lipid metabolism.

science.org
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We are recruiting a PhD student to work with us within Molecular Lipid Metabolism. Deadline for applications August 10. Please share with relevant candidates: candidate.hr-manager.net/App…
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Nature Metabolism
@NatMetabolism
26 Apr 2023
Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction dlvr.it/Sn6VKR
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Lykke Sylow@LykkeSylow
20 Apr 2023
I am perhaps a bit biased…🤷‍♀️ but this will be a fantastic opportunity to hear about a hot topic with very cool unpublished data🔥 Not to mention the great speakers @LisbethLVMoller and @Mona_ali1990 💪2 - 3pm EST Monday april 24th @MyogenesisGroup @BiomedUCPH @NEXSKU #myotwitter
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