Virology, immunology, and evolution of pandemic viruses since 2008. Tweets from lab members.
Madison, WI
Joined November 2015
- Tweets85
- Following144
- Followers366
- Likes63
We are proud of you Siyang! Congratulations on your Hilldale award!
#PharmTox student Siyang Peng is studying the evolution of the #influenza virus through observing its transmission between ferrets. Her research, done within the @tcflab, is being supported by a Hilldale Undergraduate/Faculty Research Fellowship!
pharmacy.wisc.edu/4-pharmtox…
TCF lab retweeted
After 5 great years, I've wrapped up my time in the @tcflab! Grateful to everyone in the lab & esp to @tcfriedrich for being a great mentor. And now, I'm excited to start my postdoc tomorrow studying congenital CMV with @SalliePermar at @WeillCornell! 👩🔬
Where do new #SARSCoV2 variants come from? Unusually long infections in immunocompromised people may be one important source. New preprint with @HalfmannPeter @dho and many others to look at viral evolution in one individual with a very long infection. @itsnickminor has details!
New manuscript from my work at @dho_lab is up on medRxiv!
This was my first big project on staff there, and was an extraordinary opportunity to shift gears into viral genomics and public health.
So, what did we find?
Figures & findings in thread.
New paper on H7N9 influenza evolution within and between hosts from @KATarinambraun @haddocksoto and many wonderful collaborators! Kat has the details below.
📣We compare sequence evol’n of H7N9 #birdflu to H1N1 in ferrets. Purifying selection➕ stochasticity➕ tiny bottlenecks=human-transmissible H7N9 is unlikely to emerge from spillover infxs. BUT, every infx is a pull on the evolutionary 🎰slot machine🧵1/11 go.wisc.edu/ao1l5o
TCF lab retweeted
What factors shape evolution of influenza virus within an individual? Happy to share our collaborative work led by @kaaamato with Luis and Kat and @tcflab, @SSCLabQuips, and @KoelleLab that shows genetic bottlenecks restrain intrahost influenza virus evolution. 1/10
Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks biorxiv.org/cgi/content/shor… #bioRxiv
Great work here from current and former lab members — we are especially proud of @LouiseHMoncla for her intellectual direction of this project!
New paper with #MDTP alum @LouiseHMoncla, alum/trainer @dho, and trainer @tcfriedrich!
Learn about #SARSCoV2 diversity within-host and transmission between individuals!
@UWiscPathology @uwvetmed @MadisonVirology
TCF lab retweeted
Friday paper drop! Excited to see my second paper out in @PLOSNTDs today. Check out the thread below for details on our study of the impact of prior #DENV exposure on #ZIKV pathogenesis during pregnancy. Thanks to a great team for making this happen! @AliotaLab @tcflab
Excited to present our work, now on @biorxivpreprint, to assess the impact of pre-existing dengue virus immunity on Zika virus pathogenesis during pregnancy in NHP. 🧵Thread below with our primary findings! biorxiv.org/content/10.1101/…
TCF lab retweeted
Love having amazing colleagues and VIROLOGY?
UW-Madison is looking to hire a new faculty member who loves working on viruses as much as we do! jobs.hr.wisc.edu/en-us/job/5…
Congrats @KATarinambraun ! We are all proud of you!
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TCF lab retweeted
Great interview with MSTP @KATarinambraun- check out Here & Now for April 9, 2021 pbswisconsin.org/watch/here-…
TCF lab retweeted
Today, @SenatorBaldwin joined @BeckyBlank and researchers @tcfriedrich, @dho, @KATarinambraun, @GageKMoreno and others to discuss #UWMadison efforts to sequence variants and study transmission of the virus that causes #covid19.
TCF lab retweeted
Great work from #MDTP trainers @dho_lab and @tcflab using viral sequencing to track SARS-CoV-2 variants in Wisconsin!
The pandemic's tiniest shifts — virus mutations — could cause its biggest problems. #UWMadison scientists keep watch by making Wisconsin a genome-sequencing hotspot. news.wisc.edu/viral-sequenci…
TCF lab retweeted
#COVID19 work continues for MSTP student @KATarinambraun alongside the labs of @tcfriedrich and @dho - “You know you want to be able to track how each of those viruses is circulating, which viruses are circulating, because it will save lives."
The pandemic's tiniest shifts — virus mutations — could cause its biggest problems. #UWMadison scientists keep watch by making Wisconsin a genome-sequencing hotspot. news.wisc.edu/viral-sequenci…
TCF lab retweeted
Preprint 🧵Using viral sequencing + some epi data, we show that a majority #SARSCoV2 infections in healthcare workers at our institution occur in the community and can only rarely be traced to a #COVID19 patient source. @GageKMoreno @dho @tcfriedrich 1/12 medrxiv.org/content/10.1101/…
Important thread here on #SARSCoV2 evolution and the “UK variant” from an outstanding science writer.
There’s a lot of concern and confusion right now about the new #sarscov2 variant identified in UK. I’ve spent today and yesterday talking to a dozen people working on this. My story is here: sciencemag.org/news/2020/12/…
Thread to come (may be long and slow)
TCF lab retweeted
Check out this thread from #MDTP student @chelsea_crooks4 on her new paper with MDTP trainers @tcflab and @dho_lab on African-lineage #Zika pathogenesis in pregnancy! 👇
Excited to share my work to characterize African-lineage #Zika during pregnancy in NHP! Thread 🧵 below with our primary findings: biorxiv.org/content/10.1101/…
TCF lab retweeted
Check out our preprint! We deep sequenced #SARSCoV2 viruses longitudinally before & after transmission in 🐱s. We observed narrow (& potentially non-random) transmission bottlenecks and argue cats may be a useful model. @GageKMoreno @tcfriedrich 🧵1/
biorxiv.org/content/10.1101/…
TCF lab retweeted
My group with @slo_wis , @tcflab , regulatory support from @UWMadison, saliva guidance from @NathanGrubaugh , support from @WARF_News , @wnprc, and @NIH RADx.
First day testing van-based, fast-turnaround COVID testing by RT-LAMP. Spit in a tube (h/t @NathanGrubaugh), inactivate for 30 minutes, then RT-LAMP to look for color change. Hoping a version of this could enable twice-weekly testing of teachers to keep schools open.
TCF lab retweeted
Thanks to Andrea W. In @tcflab we now have an optimized subgenomic RNA PCR protocol available on our open research portal: openresearch.labkey.com/wiki…
TCF lab retweeted
We have been working hard to characterize #SARSCoV2 in #Wisconsin, USA. Our work is being peer reviewed now, but our preprint is available here: medrxiv.org/content/10.1101/…
Here is what we have learned about #SARSCoV2 in WI:
THREAD (1/8) @GageKMoreno
