@MehleLab

Our contribution to understanding influenza virus. At UW Madison. @uwmadisonMMI

mehlelab.com
Joined June 2015
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We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes cell.com/cell-host-microbe/f…) 1/10

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza...

King et al. develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness. A fitness-based TRPPC screen...

cell.com
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This was the result of tenacious work and deep thinking by Cason King, and offers a legacy that reflects who he was as a scientist. I thank other lab members and our collaborators in the labs of Judy Smith and @LangloisLab, and @BWFPATH for supporting risky science. 9/10.
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Find more here 10/fin. xitter.cf/cellhostmicrobe/status…
Cell Host & Microbe@cellhostmicrobe31 Aug 2023
Pathogen-driven CRISPR screening. @MehleLab develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness.TRPPC for influenza shows TREX1 tempers DNA self-sensing cell.com/cell-host-microbe/f…
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Bittersweet final lab meeting with Jordan Ranum (white shirt). Jordan is off to med school at UW Madison. He joined as an undergrad and stayed as a scientist. Watch out for his amazing project on defective viral genomes that is about to drop.
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It's been a busy work for the lab. Thomas (holding 🍾) passed his @UWMadisonMDTP qualifying exam with aplomb. Very excited to see him tackle his project as a dissertator. Congrats Thomas.
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Excited to announce the successful thesis defense by newly minted Dr. @graceschaack (seen riding her thesis gift, a T-Rex). Great public presentation and closed-door defense. Super proud to have her as a lab alumna, and returning to the clinic to complete her MD. Congrats!
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Congratulations to CMB Alums, Mitch Ledwith and Dan Tremmel, the 2022 Raymond L. Erikson Exceptional Thesis Award recipients! 🎉
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Studying how #influenza virus engages the cellular environment, @bakerlabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology plos.io/3VnlJS1
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When is an antiviral protein not antiviral? It's all about context. Cason summarized our current thinking about the subtle balance between pro- and antiviral activities. Free access for 50 days authors.elsevier.com/a/1fvVU…
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The fun begins at #ASV2022. Come see the exciting work from the lab with presentations Saturday by Jordan (W5-12), Sunday by Cason (W16-6) and Grace (W16-9), and Tuesday by Andy. All lab members are available to offer expert, local advice on best places for food, coffee and beer.
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Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks @kaaamato @mehlelab @tcflab @UWMadisonMMI #influenza #flu #virology go.nature.com/3PqiuXw
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Our NSV talks highlighted some of the fun projects in the lab. If you found them as interesting as we do, and you're looking for a postdoc, reach out. We're looking for someone to join our team. See pic for details. Drop a line to chat, or find Andy at #NSV2022.
Postdoc add for Mehle Lab.

ALT Postdoc add for Mehle Lab.

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Fantastic Suppressing and Conquering session and talk by @casonthemason at #NSV2022. Be sure to find him to ask about his favorite dinosaur.
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