@KoelleLab

We study the ecological, evolutionary, and within-host dynamics of RNA viruses using quantitative approaches. @EmoryUniversity Department of Biology

 Atlanta, GA
scholarblogs.emory.edu/koellelab/
Joined January 2020
  • Tweets126
  • Following253
  • Followers753
10Media
Excited to share our recent preprint on quantifying pandemic potential from experimental transmission studies, spearheaded by grad student Elizabeth Somsen in my group and in collab with Troy Sutton & lab at Penn State and Anice Lowen at Emory: biorxiv.org/content/10.1101/….

Quantifying viral pandemic potential from experimental transmission studies

In the past two decades, two pandemic respiratory viruses (H1N1 and SARS-CoV-2) have emerged via spillover from animal reservoirs. In an effort to avert future pandemics, surveillance studies aimed...

biorxiv.org
2
9
1
13
842
Hope to post again in less than a year :)
1
115
Collaboration with Lucas Ferreri and the Lowen lab at Emory to look at influenza virus evolution and dispersal during infection within a host: pnas.org/doi/abs/10.1073/pna…

Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary...

Viral infections are characterized by dispersal from an initial site to secondary locations within the host. How the resultant spatial heterogeneit...

pnas.org
1
10
11
1,067
Fortunate to collaborate with Rustom Antia and Jim Bull on an analysis focused on the question: Why do respiratory viruses evolve antigenically while viruses undergoing systemic replication do not? watermark.silverchair.com/eo…
1
4
451
A fun analysis with David Rasmussen focused on seeing if incomplete purifying selection impacts/biases our estimates of epidemiological parameters in phylodynamic analyses: royalsocietypublishing.org/d… (thankfully, it doesn't bias estimates much at all!)
2
6
487
And while I'm on tweeter (once in a blue moon), here are some relatively recent papers from our group!
1
73
Congratulations to Dr. Yeongseon Park for her successful PhD defense on Friday, March 7, 2025!
1
3
101
(We think this new approach is preferable to existing approaches - some of which we've developed - because it uses a different subset of viral sites to estimate transmission bottleneck sizes and is less prone to underestimation of bottleneck sizes.)
5
640
We just posted a preprint on a new approach for estimating transmission bottleneck sizes. Spoiler alert: we confirm bottleneck sizes for influenza virus and SARS-CoV-2 to be tiny using the new approach: biorxiv.org/cgi/content/shor…
7
25
3,328
Congratulations @park_yeongseon and @m_a_martin 🎉
Michael Martin@m_a_martin
29 May 2023
So excited this work led by @park_yeongseon with @KoelleLab is finally out! We show that you can use sequence data to infer epidemiological dynamics (e.g. R0) of emerging pathogens w/o trees by fitting models to the observed segregating sites trajectories. nature.com/articles/s41467-0…

Epidemiological inference for emerging viruses using segregating sites

Nature Communications - Epidemiological models are commonly fit to case and pathogen sequence data to estimate parameters and to reconstruct disease dynamics. Here, the authors present an inference...

nature.com
1
5
643
#eeid2023 Transmission bottleneck and disease severity
EEID2023@eeid2023
23 May 2023
Dr. Katie Koelle from Emory University 🦠
3
16
1,336
And now with a more accurate title! Also a gift link, so it should not be behind a paywall. nytimes.com/2023/05/10/scien…

An Experiment Repeated 600 Times Finds Hints to Evolution’s Secrets (Gift Article)

Snowflakes of yeast in a lab offer insights into how life on Earth transitioned from single-celled into multicellular organisms.

nytimes.com
6
20
1
82
15,716
Our paper on influenza reassortment in mammals is out now on @NatureComms! Congratulations to all our collaborators!rdcu.be/cZtAo @anice_lowen @LucasFerreri1 @KoelleLab @CRP_FLU_UGA @Juaco1802 @Aivlys87 @juergenricht @CEIRRNetwork #LoveVirology
6
13
1
78
This week's EEB Thurs Seminar features ALUM Dr Katia Koelle @KoelleLab presenting Using genetic data at multiple scales to understand constraints on viral adaptation. 3pm, 1010 Bio Sci Bldg and Zoom live, see poster #eventalanche #Genetics #diseases
Poster for Department of Ecology and Evolutionary Biology Seminar Series. Block M. Using genetic data at multiple scales to understand constraints on viral adaptation. Katia Koelle, Professor, Department of Biology, Emory University. Zoom link email eebsemaccess@umich.edu at least 2 hours prior for passcode. Thursday, Oct 20 3pm, 1010 BSB. Hybrid event. Live/virtual. Block M EEB. Drawing of virus cells

ALT Poster for Department of Ecology and Evolutionary Biology Seminar Series. Block M. Using genetic data at multiple scales to understand constraints on viral adaptation. Katia Koelle, Professor, Department of Biology, Emory University. Zoom link email [email protected] at least 2 hours prior for passcode. Thursday, Oct 20 3pm, 1010 BSB. Hybrid event. Live/virtual. Block M EEB. Drawing of virus cells

1
1
6
Second PhD defended from the Koelle lab this week was from @m_a_martin. Mike not only did a phenomenal quantity of work, but it was of high quality as well! Mike collaborated with many folks, @SternLab @AnnePiantadosi @Ahmed_HBabiker among others. Congrats!!
10
6
1
83
For the second preprint announcement of the day, we’ve updated our earlier manuscript on using segregating sites trajectories of viral sequence data for epidemiological inference, which was led by @park_yeongseon. biorxiv.org/content/10.1101/…

Epidemiological inference for emerging viruses using segregating sites

Epidemiological models are commonly fit to case data to estimate model parameters and to infer unobserved disease dynamics. Epidemiological models have also been fit to viral sequence data using...

biorxiv.org
1
6
Our recent work on the variolation hypothesis with regards to SARS-CoV-2 and mask wearing is now up on medRxiv. We show that mask wearing reduces the e probability of infection but does little to reduce severity given infection. medrxiv.org/content/10.1101/…

Masks Do No More Than Prevent Transmission: Theory and Data Undermine the Variolation Hypothesis

Background Masking serves an important role in reducing the transmission of respiratory viruses, including SARS-CoV-2. During the COVID-19 pandemic, several perspective and review articles have also...

medrxiv.org
10
51
15
154
This was a highly collaborative project with (undergrad!) Jack Lin, Julie Zhu, Ruston Anita, @anice_lowen, and @dbweissman
1
11
It’s PhD Defense day for @brent_allman!
1
1
1
17
Congratulations Dr. Allman 🎉
10
congratulations to Dr. @brent_allman on his amazing PhD defense! i've been very lucky to get to co-advise brent with @KoelleLab
2
4
1
19
Load more