@sunscapee

HMS Postdoc ➡️ Biotech • Neurobiology • Stem Cells • Preclinical Development • Precision Medicine ☕🌈

 Philadelphia, PA
Joined May 2011
  • Tweets836
  • Following582
  • Followers114
31Media
Hayes P retweeted
HHMI
@hhmi_scienceApr 20
Scientists just discovered new "controllers" of the brain's most elite security checkpoint. Jiefu Li & team at our Janelia Research Campus have ID'd proteins that help open & close the blood-brain barrier — a step toward treating Alzheimer's & more: hhmi.news/4mkrDT2.
Janelia Group Leader Jiefu Li (right) and his team are uncovering how the blood-brain barrier functions.

ALT Janelia Group Leader Jiefu Li (right) and his team are uncovering how the blood-brain barrier functions.

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FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n
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Out today from the Neal lab! An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbation atlas in human cells. nature.com/articles/s41592-0…
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The university will not surrender its independence or relinquish its constitutional rights. Neither Harvard nor any other private university can allow itself to be taken over by the federal government. hrvd.me/ResearchFunding25t
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IPSC-derived exosomes were found effective at reversing #PulmonaryHypertension by reducing pulmonary vascular remodeling and may provide an iPSC-free therapy for the treatment of pulmonary arterial hypertension. bit.ly/3w0wOSo
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Time-lapse of zebrafish optic cup development. Credit to @kwantourage. #ZebrafishZunday
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Our special issue on “stress” features review articles on how cells sense and respond to stresses. We also invite scientists to discuss common stressors in research and publishing cell.com/molecular-cell/curr…
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science.org/content/article/…

Feeling full? Researchers pinpoint neurons that prevent eating too much, too fast

Mouse study highlights neural circuits regulating the speed and amount of food intake

science.org
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When microglia are vacuuming the brain! 🧠 Here is an in vivo application using Bliq’s Video-rate Multiphoton System (VMS) to image microglial phagocytosis of glutamatergic neurons in a transgenic zebrafish larva (dorsal view). bliqphotonics.com/solutions/…

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With RTutor.ai, you can chat with your data in plain languages. Now upgraded to v. 0.96. Fix a bug and made GPT-4 available. Interactive plots via plotly and CanvasExpress!
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1/ Why can multiple sclerosis symptoms worsen with heat exposure, something known as the Uhthoff phenomenon? This question is especially relevant in the era of record-breaking heat waves and climate change. #tweetorial #medtwitter
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For this #FluorescenceFriday we bring a trhowback to one of our iconic serial killer T cells in honor of all the great work performed on understanding and enhancing T cell #immunotherapy using #LiveCellImaging for #CancerResearch
Nature Reviews Cancer@NatureRevCancer13 Sep 2023
NEW content online! Bridging live-cell imaging and next-generation cancer treatment dlvr.it/Sw2fL5
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Our new work in ⁦@Nature⁩ to explain how retrotransposons synthesize the 2nd-strand DNA by a circularization process. Story: made some cool findings (we thought) -> actually scooped 40-yr ago by textbook knowledge -> textbook appear to be incorrect. nature.com/articles/s41586-0…

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis

Nature - Retrotransposons hijack the alternative end-joining DNA repair process of the host for a circularization step to synthesize their second-strand DNA.

nature.com
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FDA approves first cell therapy for type 1 diabetes bit.ly/3CZU6Ie
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What if small molecules could allow you to alter protein localization at will? What if they could allow you to turn on specific transcription factors? Our new manuscript reveals bifunctional molecules to do just that. 🧵
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Optogenetics helps researchers study the role of the microtubule end-binding protein, EB1, in the growth of neurons. elifesciences.org/articles/8…
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Our understanding of how the brain and immune system interact has changed substantially over the past years and decades. A new #ScienceReview takes a look at recent discoveries that are transforming our understanding of brain immunity: scim.ag/2dv
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In rats fed a “cafeteria diet,” nicotinamide riboside (NR) reduced hepatic fat, cholesterol deposition & liver fibrosis. Matches known cholesterol-lowering effects of NMN in humans 👏 See thread for relevant papers 1/n ⬇️
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K-Means has two major problems: - Number of clusters must be known - Doesn't handle outliers But there's a solution! Introducing DBSCAN, a Density based clustering algorithm. 🚀 Read more 🧵👇
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Are you curious to try the new Segment Anything Model by @MetaAI on microscopy images? We just added it to our #BioImageAnalysis software #CellACDC. As per all the models, Cell-ACDC will automatically install and download the model and generate the GUI widget for the parameters!
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