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Finally out! The second part of my PhD, a study on fiobrostenosis in Crohn's disease co-lead with @kebojun . Read on the thread for a summary.
Our study "Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease" is out jci.org/articles/view/173835 with first authors @kebojun and @saeedfc in collaboration with @SeverineVermei1 and the @ibdleuven team
Saeed retweeted
Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in @CD, a fantastic collaboration with @gmatteoli1978 with first authors
@kebojun @saeedfc now in @jclinicalinvest
jci.org/articles/view/173835 @SeverineVermei1
As we say in India, a 'double Dhamaka' from Mucosal Immunology Lab. Super happy to be part of this study co-lead by the amazing @LiesvanBaarle @VeronicaDeSimone alongside
@LindaSchneider from @UniBonn
Excited to announce our latest article on enteric glia-macrophage communication in colorectal cancer (CRC) now published in @NatureComms! doi.org/10.1038/s41467-024-5…
Saeed retweeted
Excited to announce our latest article on enteric glia-macrophage communication in colorectal cancer (CRC) now published in @NatureComms! doi.org/10.1038/s41467-024-5…
Saeed retweeted
Our study "Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease" is out jci.org/articles/view/173835 with first authors @kebojun and @saeedfc in collaboration with @SeverineVermei1 and the @ibdleuven team
Exciting news!! IBD Leuven @ibdleuven , @gmatteoli1978 and @BoeckxstaensLab , has secured a $2.8m grant from @HelmsleyTrust for a collaborative study on the origin of fibrosis in Crohn's disease. shorturl.at/dfMW3 @bverstockt @SeverineVermei1
Saeed retweeted
It’s truly a pleasure hosting this week #Victoria #Gudiño from the @AzucenaSalas17 lab @ibd_bcn giving an excellent talk today at our weekly labmeeting! #unmetneeds #perianalCD @gmatteoli1978 @fibrotarget @HelmsleyTrust
Broke through the PhD finish line 👨🎓 Immense gratitude to my promoter @gmatteoli1978 & co-promoter @bverstockt, & to my team at the Mucosal Immunology lab @TARGID_KULEUVEN. You've made the road worthwhile.🙏
A massive thanks to the jury members @RajaAtreya @YvanSaeys @LabMazzone @bernthie for their time and effort to evaluate the thesis.
Saeed retweeted
Today our Human Lung Cell Atlas (HLCA) paper came out in Nature Medicine nature.com/articles/s41591-0…! The HLCA includes 2.4M cells from 486 individuals and 49 datasets. Check out this tweetorial to learn more about how we built it, and how you can use it (1/21)
Saeed retweeted
Our new article, "IL-1R signaling drives enteric glia-macrophage interaction in colorectal cancer progression" is now available as preprint biorxiv.org/content/10.1101/… fantastic collaboration between our lab @gmatteoli1978
@TARGID_KULEUVEN and the lab of @ProfSvenWehner @UniBonn
Saeed retweeted
📚For Tomorrow's #JournalClub Tapas Mukherjee @ImmunologyUofT will present a #preprint by @gmatteoli1978 @SeverineVermei1 labs on how CD150 monocytes promote tissue fibrosis by inducing the differentiation of FAP fibroblasts in Crohn’s disease patients💥👇
biorxiv.org/content/10.1101/…
Saeed retweeted
Really nice study - progress in an area of unmet need in #IBD – at Chicago, IL
New pre-print!! We analyzed a triad of lesions from fibrostenotic #CrohnsDisease patients (non-inflamed, inflamed & stenotic) & non-CD patients using scRNAseq. biorxiv.org/content/10.1101/…
#CD #IBD #inflammation
🧬 Key findings below.
Saeed retweeted
Another #DDW2023 poster session round today! Proud of the entire team presenting their research today, disseminating with the #IBD field! #IDeGreef #LFierens @SeverineVermei1 @JoaoPGSabino @bverstockt #MFerrante @HelmsleyTrust @TARGID_KULEUVEN – at Chicago, IL
Saeed retweeted
Taking a deep dive into the mystery of #fibrostricturing #CD! Big collaborative effort with @gmatteoli1978 @saeedfc @kebojun and many other collaborators! @SeverineVermei1 @bverstockt @SareVerstockt @DhooreAndre @bisle84 @FWOVlaanderen @TARGID_KULEUVEN @HelmsleyTrust – at Chicago, IL
New pre-print!! We analyzed a triad of lesions from fibrostenotic #CrohnsDisease patients (non-inflamed, inflamed & stenotic) & non-CD patients using scRNAseq. biorxiv.org/content/10.1101/…
#CD #IBD #inflammation
🧬 Key findings below.
Saeed retweeted
Our study sheds light on fibrostenotic #CrohnsDisease! Together with @ibdleuven we uncover pro-fibrotic signals from CD150-monocytes, leading to a specific fibroblast population causing inflammation & tissue fibrosis. Follow our @fibrotarget @HorizonEU consortium for new update
Taking a deep dive into the mystery of #fibrostricturing #CD! Big collaborative effort with @gmatteoli1978 @saeedfc @kebojun and many other collaborators! @SeverineVermei1 @bverstockt @SareVerstockt @DhooreAndre @bisle84 @FWOVlaanderen @TARGID_KULEUVEN @HelmsleyTrust
New pre-print!! We analyzed a triad of lesions from fibrostenotic #CrohnsDisease patients (non-inflamed, inflamed & stenotic) & non-CD patients using scRNAseq. biorxiv.org/content/10.1101/…
#CD #IBD #inflammation
🧬 Key findings below.
1. Inflammatory monocytes activate a specific pathogenic ECMhi fibroblast population during inflammation.
2. TWIST1 is a crucial modulator of fibroblast activation & ECM production.
🧪 Led by @kebojun & @saeedfc in an extensive collaboration between @gmatteoli1978's Mucosal Immunology lab & IBD Leuven (@Severine, @ibdleuven) at @TARGID_KULEUVEN, with crucial contributions from other collaborators. #IBDResearch #Inflammation #Fibrosis (3/3)
Saeed retweeted
1/9 Indians in the US on a work visa can't go home. There’s NO appointments.
The now ~200k H-1B Telegram group is growing by 13,000 per month.
Even with ~$40m in fees, the 5 VACs process ~10,000 a month. The next availability is ~2024!
Here’s 6 stories from hurting families:
