PhD student studying cancer immunology in the Chiappinelli Lab at @GW_IBS. Interested in epigenetics, spatial biology, and cancer immunotherapy.
District of Columbia, USA
Joined March 2022
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Trace Walker (he/him) retweeted
Considering graduate school?
Check out GW's Integrated Biomedical Sciences PhD Program. Application deadline 12/1/2024. We have some fantastic trainees and mentors! @GW_IBS
ibs.smhs.gwu.edu/
Spread the word - retweets welcome.
Trace Walker (he/him) retweeted
Our new paper on epigenome editing is out!
We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability
nature.com/articles/s41587-0…
Trace Walker (he/him) retweeted
We then show these changes are found within tissues and during aging. To learn more, check out our preprint!
Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible!
biorxiv.org/content/10.1101/…
Trace Walker (he/him) retweeted
In 2023 I led negotiations involving 9 corporations & 24 African institutions that trained 408 African scientists in genomics & bioinformatics. That effort, with >100 African authors, is now published in @NatureGenet. Thanks to all contributors: nature.com/articles/s41588-0…
Trace Walker (he/him) retweeted
Two papers in @Nature present a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. The approach may provide an easier method of genome editing.
go.nature.com/3RGkI8M
go.nature.com/3RHBvIs
ALT This is figure 1 from the paper from Patrick Hsu and colleagues, which shows that IS110 mobile genetic elements express a ncRNA that is bound by its encoded recombinase.
Trace Walker (he/him) retweeted
With 3 approved epigenetic drug classes and many more under clinical investigation, epigenetic targets are gaining traction. Here, we take survey of developments and hurdles in targeting the cancer epigenome. Thank you @NatureCancer for the opportunity
nature.com/articles/s43018-0…
Trace Walker (he/him) retweeted
It's great to see the response to this work by @KeithSiew and @LTubularCentre on the impact of spaceflight on kidney structure and function. Extremely proud to be a part of this and special thanks to @HFazelinia for bringing me along. #CosmicKidneyDisease
nature.com/articles/s41467-0…
Trace Walker (he/him) retweeted
Accelerate real-time cell morphological analysis - pushing everything everywhere all at once! 💨👇🏻
*Real-time cell image acquisition + segmentation @10GB/s using FPGA (see top left)
*Real-time (subsampled) DL image classification (green vs yellow cell states) on RTX 4090 GPU (1000’s cells/sec)
*Real-time data visualization of morphological descriptors (cell size & textures) sync with DL step.
Petabyte single-cell image data analytics is not impossible - but needs much bigger effort on data management…….
This is an on-going effort extended from our #FACED imaging cytometry platform:
nature.com/articles/s41596-0…
Trace Walker (he/him) retweeted
Strong showing from the Chiappinelli Lab at the MITM Retreat 2024! PhD students Kevin Nestler and Trace Walker won 1st and 2nd place poster prizes!
Trace Walker (he/him) retweeted
Granted tenure and promotion to Associate Professor @GWSMHS, effective July 1. Many thanks to my mentors, collaborators, and colleagues, but most of all to the extraordinary Chiappinelli Lab members who worked so hard, together, through challenging times. Onward!
Trace Walker (he/him) retweeted
The Chiappinelli Lab is hiring a research assistant! Please apply below and share widely:
gwu.jobs/postings/108936
No matter what facet of biology or medicine you might work in, it is worth challenging your perceptions of cellular processes through the lens of a highly active environment! This is definitely worth a read. #Biology #physics #medicine
Fast Biology 🚀
Cells are crowded, frenzied places. Sugar molecules cruise at 250 mph. ATP synthase whips around 134 times per second.
But these numbers seem made up. How do we know they're real?
My first editor's column for @AsimovPress.
asimov.press/p/fast-biology
Trace Walker (he/him) retweeted
Heatmap can be the worst data visualization if you aren't doing it right. For example, reordering/grouping rows & columns gives a completely different look to a heatmap from the same data.
Tutorial for programmatically re-order rows/columns here: github.com/cxli233/FriendsDo…
Trace Walker (he/him) retweeted
Do you know an undergrad in their 2nd or 3rd year thinking about grad school for biochem/biophys but hasn't had any hands-on research experience yet? We have a program for them (fully paid - $6K for 8 weeks!)
biochem.wustl.edu/resources/…
Please repost/share!
Trace Walker (he/him) retweeted
Much needed web-based tool in the TE field! Designs guideRNAs for TEs and TE-subfamilies. Looking forward to use this approach!
mobilednajournal.biomedcentr…
Trace Walker (he/him) retweeted
Online Now: Epigenetic regulatory layers in the 3D nucleus dlvr.it/T1YX8L
Trace Walker (he/him) retweeted
NEW content online! Towards targeting transposable elements for cancer therapy dlvr.it/T1T5Z2
Trace Walker (he/him) retweeted
Our new SSSavi system - a modular dCas9-based recruitment platform for combinatorial epigenome editing, led by @TessaASwain and @BlauerPlums doi.org/10.1093/nar/gkad1108
