@rohanbme

@BloodCancerUtd Fellow @Leonard_zon Lab Macrophage-MDS-AML @BostonChildrens @Harvardmed | Ph.D. @ProfSamiraMusah @DukeU CHD-AKI-CKD |Prev @novartis

 Boston, MA
scholar.google.com/citations?user=eQdDcRcAAAAJ&hl=en
Joined August 2019
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15Media
Thrilled to share that a part of my Ph.D. work from @DukeU @DukeCBTE @ProfSamiraMusah Lab is now out in @natBME! We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.
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Thrilled to receive the CDP Fellow Award from @BloodCancerUtd to support my research on leukemia & macrophages! Grateful to my postdoc mentor @leonard_zon and collaborators for their guidance & support. Excited to advance this work & contribute to the fight against blood cancer.
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Katalin Susztak
@KSusztakSep 22
We updated our Susztaklabbiobank website susztaklab.com For almost two decades our laboratory has collected and profiled human kidney tissue, paired it with mouse and rat models and with the genetics of millions of people, and built one of the most complete maps of the human kidney that exists. This site is where we share it: genome-wide association results, expression, methylation, protein and open-chromatin maps, single-cell and single-nucleus atlases, spatial transcriptomes and animal-model resources, each in an interactive browser you can query today. Please send your suggestions how we could improve our site. Let's cure kidney disease together !

Resources · SusztakLab Biobank

The SusztakLab Biobank: human kidney genetics, epigenomics, single-cell and spatial atlases, and mouse and rat models, shared openly for research by the Susztak Laboratory at the University of...

susztaklab.com
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Jennifer Trowbridge@TrowbridgeLabSep 21
The Jackson Laboratory is a wonderful, collaborative place to pursue basic & translational science. On the faculty job market? I strongly encourage you to consider joining us in Bar Harbor, Maine! Apply: go.jax.org/276n55 #JAXresearch #JAXstemcellsdev

Faculty Positions

The Jackson Laboratory is inviting applications for positions at our Mammalian Genetics campus in Bar Harbor, Maine, and our Genomic Medicine campus in Farmington, Connecticut

jax.org
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Daniel Bauer@danielevanbauerSep 16
Inspired by Gibson cloning, we describe prime assembly, now published, for in cellulo targeted integration of gene-sized DNA fragments using prime editing. nature.com/articles/s41586-0…

Targeted genomic integration and rearrangement using prime assembly

Nature - Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding,...

nature.com
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Dr. Len Zon@leonard_zonSep 12
Every so often, a major event happens in your life to validate years of work. SRRK’s ISEMBYLD was FDA approved. Having participated in its development from basic science to approval, as a physician-scientist, this is one of my best days. Happy for ISEMBYLD to help SMA patients.
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Lara Wahlster@LWahlsterSep 4
We cut the ribbon & the Wahlster Lab is officially open! 🎉🔬 #NewPI #NewLab #PediatricCancer #CancerResearch #Hematology #HumanGenetics #Genomics #PhysicianScientist 🙏 to @bloodgenes @BostonChildrens @DanaFarber @BWFUND @ASH_hematology @DamonRunyon – at Boston, MA
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Vijay Sankaran
@bloodgenesAug 7
🚨Two complementary preprints from our group reveal convergent mechanisms of inherited B-ALL predisposition. Check out this terrific work led by @LWahlster, @ALNeehus & #AndrewLee! biorxiv.org/content/10.64898… biorxiv.org/content/10.64898…
🤖 Made with AI
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Karuna Ganesh@KarunaMDPhDAug 5
Thrilled to share our latest work is out today in @Nature ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. nature.com/articles/s41586-0…

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Nature - The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

nature.com
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Dr. Len Zon@leonard_zonJul 28
We’re incredibly grateful to Legal Sea Foods for their continued support of my lab at Boston Children’s Hospital. This year, Matt King, Brand President & COO, presented a donation made possible through proceeds from kids' meals at Legal Sea Foods. Thank you for your support!
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Shiv Grewal@grewalshJul 8
Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41467-0…
🤖 Made with AI
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Katalin Susztak
@KSusztakJun 14
😍🆕Great to see our APOL1 proteomics score (APRS) featured by @NatureGen . The work demonstrates how large-scale human proteomics can bridge the gap between genetic risk and clinical disease, bringing us closer to precision medicine for patients at risk of kidney failure. Congratulations to the entire team. @novartis @chenyu Penn Medicine Biobank nature.com/articles/s41588-0…

Proteomic prediction of APOL1-associated kidney disease

Nature Genetics - Proteomic prediction of APOL1-associated kidney disease

nature.com
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Michael Honigberg, MD, MPP@mchonigJun 10
Delighted to contribute to this story now in @Nature led by T. Gerhardt & @cam_phd - In humans & 🐭, exercise and 🛌 showed mutation-specific effects on clonal hematopoiesis, selectively reprogramming mutant cells toward less inflammatory states. nature.com/articles/s41586-0…

Mutation-dependent responses to sleep and exercise in clonal haematopoiesis

Nature - Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

nature.com
Cameron McAlpine@cam_phdJun 10
We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. nature.com/articles/s41586-0…
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Katalin Susztak
@KSusztakMay 13
🤪🆕📰Our lab's newest paper ! KDM1A regulates nephron progenitor programs and is associated with human kidney disease risk academic.oup.com/ndt/article… by @KLPrasu @DhanunjayMukhi Jonathan Levinsohn , Andi Bergerson , @Yan186186 @Hongbo919Liu @briancapell @Neph_Times @NDTsocial
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Katalin Susztak
@KSusztakApr 29
🗞️📸🌟🤩Beautiful work led by @BernhardDumoul1 with the team builds a single cell spatial atlas of human DKD using Xenium + CosMx + snRNA-seq. @Nature This is not incremental. This is a new layer of pathology. Diabetic kidney disease (DKD) is still treated as one disease. That is the problem. Patients look similar clinically but behave very differently. We asked: is there a biologically distinct subgroup we are missing? rdcu.be/ff6ZZ
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Dr. Len Zon@leonard_zonApr 26
Congrats to my friend and colleague, George Daley, for his induction into the National Academy of Sciences.
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Dr. Len Zon@leonard_zonMar 27
Very honored to give the Richard B. Johnston, Jr., MD March of Dimes Prize Lecture today at the SRI meeting in Puerto Rico. Emre Seli presented the award to me. Very appreciative to my lab and to my family.
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Dr. Len Zon@leonard_zonFeb 17
Honored to be selected as this year’s March of Dimes Prize awardee. Grateful for the incredible work my lab has done over the years. I embraced developmental biology when I started my lab and am excited to see its principles translate to patients. marchofdimes.org/about/news/….

Renowned Developmental Biologist Wins March of Dimes Prize

March of Dimes names Dr. Leonard Zon winner of the 2026 Richard B. Johnston Jr., MD Prize for breakthroughs in developmental biology and treatments for blood disorders.

marchofdimes.org
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Shiv Grewal@grewalshJan 7
Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance and cancer👉nature.com/articles/s41586-0…
Read in Nature 👉https://www.nature.com/articles/s41586-025-09899-8

ALT Read in Nature 👉https://www.nature.com/articles/s41586-025-09899-8

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Gaurav Agarwal@GauravA_UKJan 2
What protects some people from leukemia? Thrilled to share work from the @bloodgenes lab, now published in @Science. We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP. science.org/doi/10.1126/scie… 🧵👇 (1/n)

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in...

science.org
Vijay Sankaran
@bloodgenesJan 2
Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/scie… 🧵
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Michael Kharas MSK@KharasLabJan 1
Check out our latest story science.org/doi/10.1126/scie…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in...

science.org
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