@cam_phd

Brain-body circuits in sleep, heart, and brain disorders @IcahnMountSinai @SinaiHeartBlood @SinaiBrain @SinaiImmunol

 New York City
labs.icahn.mssm.edu/mcalpinelab/
Joined December 2017
  • Tweets597
  • Following1.7K
  • Followers1.6K
38Media
We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. nature.com/articles/s41586-0…
8
41
3
193
21,277
Check out our review on modeling the exposome in murine cardiovascular disease! We need to expand holistic whole organism models to study lifestyle and environmental impacts on health to identify evolutionarily selected inter-organ mechanisms that can be therapeutically harnessed
Matthias Nahrendorf@MatthiasNahrendSep 19
Modeling the Exposome in Murine Cardiovascular Disease | JACC: Basic to Translational Science jacc.org/doi/10.1016/j.jacbt…

Modeling the Exposome in Murine Cardiovascular Disease:

jacc.org
5
1
16
1,922
Cameron McAlpine retweeted
Eric Topol
@EricTopolAug 6
Of the major age-related diseases (cardiovascular, cancer, neurodegenerative) heart is the most preventable with lifestyle factors and medications. It's about to become far more preventable! @Drroxmehran and I teamed up for this @JACCJournals perspective A "once-in-a-generation opportunity" jacc.org/doi/10.1016/j.jacc.…
14
112
7
452
56,404
Officially published @jclinicalinvest - Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes @MoffittNews 🚨 It's not just whether clonal hematopoiesis (CH) is present - it's how it evolves that matters.🚨 jci.org/articles/view/204429
3
21
2
59
8,275
Cameron McAlpine retweeted
Miriam Merad, MD, PhD@MiriamMeradJul 16
Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…
14
99
6
369
35,486
Cameron McAlpine retweeted
Sasha Gusev
@SashaGusevPostsJul 14
Thought-provoking paper on interactions between genetic risk and exposures/behaviors: nature.com/articles/s41588-0…
2
14
47
8,171
My lab is expanding and I am looking for postdocs to join our team! If you are driven to pursue impactful science, have an interest in neuro-cardio-immunology, and want to live in vibrant NYC (with subsidized housing), please reach out! labs.icahn.mssm.edu/mcalpine…

McAlpine lab - McAlpine Laboratory

Welcome to the McAlpine lab! Welcome to the McAlpine lab! The heart and brain are vital co-dependent organs and communication between them is essential to health. We study the immune and neural...

labs.icahn.mssm.edu
1
9
17
1,649
New online! Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis dlvr.it/TT97Xj
1
5
14
1,238
We are happy to share another paper from the lab! Led by Lena Gaebel, using unconditioned cell transplant and congenic tracking, we show that Tet2 or Jack2 clonal hematopoiesis do not modify murine tauopathy. journals.sagepub.com/doi/10.…

Tet2 and Jak2 clonal hematopoiesis do not modify murine tauopathy - Lena Gaebel, Teresa Gerhardt,...

Background Clonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neuro...

journals.sagepub.com
3
8
670
Cameron McAlpine retweeted
nature
@NatureJun 16
Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis go.nature.com/4xpf12h

Mutation-dependent responses to sleep and exercise in clonal haematopoiesis

Nature - Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

nature.com
1
22
1
98
24,674
Cameron McAlpine retweeted
Michael Honigberg, MD, MPP@mchonigJun 10
Delighted to contribute to this story now in @Nature led by T. Gerhardt & @cam_phd - In humans & 🐭, exercise and 🛌 showed mutation-specific effects on clonal hematopoiesis, selectively reprogramming mutant cells toward less inflammatory states. nature.com/articles/s41586-0…

Mutation-dependent responses to sleep and exercise in clonal haematopoiesis

Nature - Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

nature.com
Cameron McAlpine@cam_phdJun 10
We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. nature.com/articles/s41586-0…
6
1
25
2,701
OUT NOW | PRESS RELEASE In NEW STUDY, @IcahnMountSinai researchers Teresa Gerhardt, @cam_phd, et al. discovered that moderate-to-vigorous physical activity associated w/ reduced incidence of gene-specific CH & fewer mutant cells in blood. PRESS RELEASE👉 mountsinai.org/about/newsroo…
1
5
9
673
Cameron McAlpine retweeted
Eric Topol
@EricTopolJun 10
Blood stem cell mutation clones (CHIP) occur frequently with advanced age and portend risk of cardiovascular disease and cancer. A new report @Nature today tells us about suppression of CHIP by sleep health and exercise in the experimental model and people Data below for exercise, seen in both women and men nature.com/articles/s41586-0…
5
31
2
121
30,562
Cameron McAlpine retweeted
Pradeep Natarajan
@pnatarajanmdJun 10
Delighted to participate in this paper spearheaded by @cam_phd with key human genetics contributions from @mchonig lab! @broadinstitute @MGBResearchNews @harvardmed
Eric Topol
@EricTopolJun 10
Blood stem cell mutation clones (CHIP) occur frequently with advanced age and portend risk of cardiovascular disease and cancer. A new report @Nature today tells us about suppression of CHIP by sleep health and exercise in the experimental model and people Data below for exercise, seen in both women and men nature.com/articles/s41586-0…
1
4
34
10,788
Combining human cohort data with murine models harboring mutations in Jak2, Tet2, Tp53, and Dnmt3a, we find that sleep and exercise attenuate the clonal trajectories of Jak2 and Tet2 CH by selectively reprogramming mutant hematopoietic progenitor cells.
1
6
730
Healthy behaviors also restrict the inflammatory phenotype of CH mutant vascular macrophages through novel brain-body mechanisms to reduce atherosclerotic burden, independent of peripheral clone dynamics.
1
4
439
Cameron McAlpine retweeted
Erik Musiek@ErikMusiekJan 30
Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS pnas.org/doi/10.1073/pnas.25…

REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS

The molecular circadian clock is a ubiquitous transcriptional–translational feedback loop that regulates CNS function, glial responses, and neurode...

pnas.org
1
9
1
22
1,713
Cameron McAlpine retweeted
Panos Roussos@panos_roussosJan 21
Now out in @Nature: Biological insights into schizophrenia from ancestrally diverse populations. With @MountSinaiPsych @SinaiBrain @SinaiGenetics @CDNeurogenomics @POPGEM_Lab #MillionVeteranProgram and collaborators across consortia. Read: rdcu.be/eZ7he
5
23
1
69
8,547
This new track for accelerated manuscript publication has been well received! Thank you authors! Please consider JACC: BTS if you have been rejected. Turn a no into a yes, rapidly 👌🏻
Matthias Nahrendorf@MatthiasNahrend24 Nov 2025
JACC: BTS is introducing a new program: 👇 We invite you to submit work that has been rejected by another journal. One common frustration for authors is having to submit a manuscript multiple times. We help reduce the sting of rejection.
1
8
1,226
🚀2026 IS HERE & The @ScottRussoPhD led #BrainBodyResearchInstitute Seminar Series returns Jan 27th to launch an exciting 2026 season. Join us for cutting-edge talks from leaders in #BrainBody research. See you there! RSVP HERE👉mountsinai.zoom.us/webinar/r…
10
2
25
5,292
Load more