protein engineering with Rube Goldberg machines at Boston University
Cambridge, MA
Joined May 2019
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Gordon Rix retweeted
Meanwhile, the Sergi Lab Supplies do not waste money on website design and are able to offer the same literally for 10x cheaper
a labware company that has prices & buy buttons on their website?! finally someone that likes making money
clickbio.com
Gordon Rix retweeted
I have been selling magnetic racks and magnetic beads for several years now.
Magnetic racks are about 65% of sales.
Magnetic beads for DNA purification are only 9%.
I assume that you use the racks mainly for DNA purification.
Am I wrong? If not, is there something wrong with my beads? I would expect much more magnetic beads sales.
I would greatly appreciate to learn why you would not choose my beads. Price too high? Or too low? Too good to be true? You tested the sample of beads with NEB ladder and it didn't work? Something else?
Gordon Rix retweeted
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s41467-0…
Gordon Rix retweeted
In this work, we bring OrthoRep’s mutation rate up to 10^-4 substitutions per base, allowing us to durably hypermutate and evolve chosen genes in vivo at 1-million times the genomic mutation rate of the host yeast cell. What does this afford? biorxiv.org/content/10.1101/…
Gordon Rix retweeted
Let me show you how to DOUBLE your sequence throughput and read length using this one weird trick. @nanopore HATES this. – at New York, USA
ALT Nanopore device next to a jar of peanut butter.
Gordon Rix retweeted
New experiment this week for COB...
I'm releasing a new software tool + an accompanying essay 🧬
Learn more about *The Interactive Mutation Browser*
Gordon Rix retweeted
WE👏 ARE👏AWARE👏THE👏LOGO👏LOOKS👏LIKE👏A👏BEARDED👏DUDE👏IN👏AN👏ORANGE👏HAT👏
—YOU👏DO👏NOT👏NEED👏TO👏KEEP👏POINTING👏THAT👏OUT👏EVERY👏SINGLE👏DAY👏
Gordon Rix retweeted
Never forget: the people telling you that fedoras don't look awesome, are people who think you don't deserve to look that good.
Gordon Rix retweeted
ML for bio is fed all the DNA sequences of nature and makes a beautiful glowing enzyme
ML for tech is fed all the content from the internet and makes a toxic psycho chatbot
As you choose your next career moves remember that you have to live in the world you build
Gordon Rix retweeted
Definitely don't put the entire plate including the polystyrene into a blender with some LB, homogenize, and then filter the paste through a Buchner funnel and culture the filtrate... unless...?
Gordon Rix retweeted
I'm excited to announce the release of our hardware-agnostic interface to liquid-handling robots, PyLabRobot. PyLabRobot provides a common language for communicating with different types of robots in Python.
Github repo: github.com/pylabrobot/pylabr…
youtube.com/watch?v=s808Eg44…
Gordon Rix retweeted
New this week! In vivo continuous evolution takes advantage of cycles of rapid mutation, amplification and selection inside living cells @cnb_csic @CSIC @Beatriz_Al_Go @lafdez_synbio @chang_c_liu @haiqi_chen @UTSWScience @francesarnold @zerlinia
go.nature.com/3FXKnCK
Gordon Rix retweeted
Today, we present peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomizable 3-bp “signature” sequence that serves to record a cellular event. The result: temporally-resolved cellular event recording! 1/12 biorxiv.org/cgi/content/shor…
Gordon Rix retweeted
Happy to share that our OrthoRep-driven transcriptional biosensor evolution work is now published in @ACSSynBio. Congrats to Alex Javanpour! pubs.acs.org/doi/10.1021/acs…
Congrats to Alex Javanpour for using OrthoRep to evolve a series of high-performance biosensors based on the BenM transcription factor. (1/4)
biorxiv.org/content/10.1101/…
Gordon Rix retweeted
The Boss is Back, Baby.
In one month, The Boss Baby: Family Business is coming to theaters and @peacockTV on July 2.
Gordon Rix retweeted
More exciting stuff coming later on how I'm going to drop all these costs. Once I hit the goal of $2 for build+miniprep+sequencing, I am going to attempt to build a genome myself. In particular, I want to build Bacillus subtilis PG10 in a modular fashion (for less than ~8k)