@chorye
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Assistant professor @Duke, guerilla knitter, pipettor of small volumes of liquid. Biologist masquerading as engineer, or the other way around.
Durham, NC
Joined November 2009
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Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to 1D axis.
Imagine if you could sample 200 dimensions at once, with data to boot 📈
First @chorylab PACE preprint on our new system to tackle this: TurboPRANCE👇
Aaaand it’s online ahhhhh!!! 🥳🥳 So excited!!
The first glimpse of my postdoc work with @chorye @dukecagt. Here, @stefanmgolas and I developed TurboPRANCE, an open-source robotics platform for rapid and scaled phage-assisted continuous evolutions. 🧪Tweetorial party!👇1/n
Emma J Chory retweeted
Today in @Nature, we report a new approach to studying human brain development and modeling disease in vivo.
Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.
To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.
We call these #xenocortical mice (XCX).
Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!
Link to the article below 👇
Emma J Chory retweeted
1/ I have long dreamed of systems that could causally model human neurobiology across scales, from molecular to behavioral.
In @Nature, delighted to share our efforts at creating xenocortical mice where human organoids grow to occupy most of mouse cortex.
Emma J Chory retweeted
I suspected it would be good but was still absolutely blown away by @GallowayLabMIT's talk today. Fundamental work presented with incredible clarity of thought and joyful levity. The kind of talk that's so good it makes you a little jealous that you didn't do it.
Heading across the river tomorrow for the Harvard Systems Biology Seminar at noon. I'll definitely discuss this paper and some nifty unpublished things. hope to see folks there!
@harvardmed @HMS_SynBioHIVE @HMS_SysBio @baym @NoahOlsman
ASBMB is excited to announce the Future of Discovery Program and ASBMB Impact Fund, two new initiatives that will expand travel award support for graduate students and postdoctoral fellows attending the ASBMB Annual Meeting.
Learn more & apply: asbmb.org/asbmb-today/societ…
#ASBMB2027
ALT Promotional graphic for the ASBMB Annual Meeting 2027 in Boston, April 3–6. White text on a blue and teal background with a DNA helix illustration reads: “ASBMB expands graduate student and postdoc travel awards.” ASBMB Annual Meeting ’27 branding appears at the top with “Molecular Bioscience.”
Emma J Chory retweeted
The vast majority of immigrants with U.S. STEM PhDs use the OPT program to stay in the country. The world has a shortage of people with these skills. It is our advantage that they're drawn to our university STEM programs--which are the best in the world.
Emma J Chory retweeted
Looks like there is a new NSF postdoc fellowship specifically for people interested in training at the intersection of AI x Bio.
I'd be happy to sponsor someone who would like to work in our group on evolution+AI related stuff
nsf.gov/funding/opportunitie…
Emma J Chory retweeted
Today, we're kicking off the first phase of the research preview for Model Hardware Standard (MHS): a new standard for AI agents to safely operate physical equipment in scientific research and advanced manufacturing.
Read more: anthropic.com/news/model-har…
Emma J Chory retweeted
Very excited to announce the PyLabRobot Cookbook from the Chory Lab! This cookbook showcases many usage examples and design patterns that should help you get started writing PyLabRobot code quickly. I strongly recommend this cookbook to anyone interested in lab automation!
More @pylabrobot learning resources forthcoming!
Check out the PyLabRobot cookbook made by @wasserstein_rao and @chorye:
chory-lab.github.io/plr-cook…
Emma J Chory retweeted
The Shuken Lab is opening @hkust in January 2027! Looking for people at postdoc, grad student, and RA levels to help us fight brain aging and neurodegenerative diseases with chemical biology and proteomics!
Www.shukenlab.com/join-us
Just an average day in the Chory Lab. We’re hiring! Come work with us and do cool stuff.
academicjobsonline.org/ajo/D…
BIOMNI AI be like, “Cloning protocol? here’s sufficient detail to execute on a robot.”
BSL2+ lentivirus production & transduction protocol? “Just do it.”
Cool cool cool cool cool.
science.org/doi/10.1126/scie…
Emma J Chory retweeted
A grant cap tells scientists there is a limit to their discoveries. The entire capitalist critique of communism is literally that when you put ceilings on what people are allowed to aspire to, collective ambition shrinks, and innovation becomes less likely.
I would really encourage people to do a quick RePORTER search for a few HHMI faculty or recipients of NIH Pioneer, Transformative Research R01, or Outstanding Investigator R35 awards, and look at how many NIH grants they had when they reached that level.
Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬
This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
Congratulations to our 2026 Beckman Young Investigator Awardees! Twelve Researchers Selected to Receive $7.2M in Total Science Funding for Cutting-edge Research beckman-foundation.org/lates… #beckmanresearch #newlyawarded
In other news, today the NIH proposed caping the maximum of grants at 2 per research lab, including collaborations.
grants.nih.gov/grants/guide/…
We're living in the upside down.
Lila Sciences may raise about $2 billion at an $8.5 billion valuation.
That number looks incredible if you treat Lila as a normal AI biotech. It makes a little more sense (maybe!) if you treat it as a bet on a new R&D operating system.
Lila’s pitch is AI Science Factories: AI systems connected to automated labs that generate hypotheses, design experiments, run them, learn from the results, and repeat. In other words: model, robot lab, experiment, data, repeat. The whole shebang.
Or “scientific superintelligence” and “operating system for science," as Lila calls it. (3/7)
I encourage everyone who is deeply concerned about this proposal to submit a public comment by Aug 3, here: rfi.grants.nih.gov/?s=6a1f20…
Asked 3 different science AIs (+ Claude) the same question today: what’s the best/most current PMCID citation for the number of cancer deaths per annum from solid tumors.
The only good answer still came from texting the neurosurgeon whose office is next door.
This is a horrifically dumb take even for @BiotechMongoose.
Even when the odds are long, and not in your favor, these awards matter. They give young scientists ambitious, almost impossible goals to aim for. Their impact is not only on the few people who win, but on everyone who stretches toward that standard, pushing science forward. When these opportunities disappear, so do the aspirations they inspire.
Emma J Chory retweeted
very sad! the DP5 grant launched my academic career
