Joined February 2008
rish retweeted
i gave 5.6 sol access to my camera roll and had it extract pictures of every piece of clothing i own from my photos then, told it to find new outfits for me and render them on me with gpt-image! its kinda cool to see your entire wardrobe in a collection like this
i'd love to see interesting things people have built with 5.6 sol. i will send the person who made the coolest thing a special gift from the openai archives.
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rish retweeted
Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months. Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions. BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible. Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile)
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Oh ffs
Reporter: How do you define ceasefire? Trump: In that part of the world, ceasefire is when you're shooting in a more moderate manner
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For all the measures regulated by the EU I’m surprised they don’t force airlines to allow you to cancel extras you paid for but no longer need or want to change (like baggage). @ryanair @eurowings if I pre purchased a lighter suitcase and want to instead bring a heavier one instead, or the other way around, why should I have to pay for both?
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This is the aspect of climate change that I worry most about — when instead of seeing gradual degradation, we cross an irreversible line.
This should be a bigger story.  Scientists are more concerned than ever that a critical Atlantic current will collapse soon and wreak havoc on North America and Europe. The Atlantic Meridional Overturning Circulation, or AMOC, is a massive conveyor belt of ocean currents that transports water from the tropics to the Atlantic.  Without it, severe weather would impact both regions at potentially devastating rates. These scientists aren't just warning us about an environmental issue—they're sounding the alarm about a climate threat that could fundamentally rewrite how future generations survive on our planet. theguardian.com/environment/…
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Why can’t we ban these posters @mybmc
Bombay in 2026. Looks about 400 times worse than it did 30 years ago. - more crowded - more filthy - illegal posters everywhere - even less civic sense - infinitely more corrupt Great progress. @MTPHereToHelp @MumbaiPolice @mybmc Doing an excellent job.
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outstanding and on-the-money thread on what just happened in hungary. worth your moment.
okay I guess I have to talk about Péter Magyar here. Let me just start with saying, in a very unladylike way, that you guys seem to have zero clue what happened in Hungary in the last two years, you completely miss the point, and you're a disappointing bunch. Let's go.
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This just played out exactly as predicted
So, a couple of the boys have been texting me: “Why the hell would Trump drop the Hormuz blockade bomb on a Sunday? It’ll send oil screaming past $120, maybe $130 if the algos really panic. Makes zero sense if you actually want cheaper barrels.” But it makes perfect sense. Beautiful, even. See, Tokyo and Hong Kong are already humming by the time the East Coast is still nursing its coffee. Those futures pits—Dow, S&P, the whole equity complex, plus Brent and WTI on the screens—never really sleep. You’ve got fourteen, fifteen hours of runway before the New York bell. Plenty of time for the right hands to lean in: long the indices in Hong Kong, short the crude in Tokyo, riding the fear wave as the blockade tweet lights up every terminal from Singapore to Sydney. Then, right on cue, before the U.S. opens, comes the pivot. Something about “there’s regime change in Tehran,” “we can do business,” “Talks were Good,” the usual art-of-the-deal baloney. Markets whip around like they’ve been Tasered. Oil gives back the spike, stocks rip higher. The boys in Asia unwind clean, pocket the spread. A few hundred million, maybe more, conjured out of thin air on the back of one perfectly timed Sunday morning post. Not bad for a morning’s work. The Street’s been running these kinds of games for decades: information, timing, leverage. Just never quite so… presidential!!
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Wharton’s latest AI study points to a hard truth: “AI writes, humans review” model is breaking down Why "just review the AI output" doesn't work anymore, our brains literally give up. We have started doing "Cognitive Surrender" to AI - Wharton’s latest AI study points to a hard truth: reviewing AI output is not a reliable safeguard when cognition itself starts to defer to the machine.when you stop verifying what the AI tells you, and you don't even realize you stopped. It's different from offloading, like using a calculator. With offloading you know the tool did the work. With surrender, your brain recodes the AI's answer as YOUR judgment. You genuinely believe you thought it through yourself. Says AI is becoming a 3rd thinking system, and people often trust it too easily. You know Kahneman's System 1 (fast intuition) and System 2 (slow analysis)? They're saying AI is now System 3, an external cognitive system that operates outside your brain. And when you use it enough, something happens that they call Cognitive Surrender. Cognitive surrender is trickier: AI gives an answer, you stop really questioning it, and your brain starts treating that output as your own conclusion. It does not feel outsourced. It feels self-generated. The data makes it hard to brush off. Across 3 preregistered studies with 1,372 participants and 9,593 trials, people turned to AI on over 50% of questions. In Study 1, when AI was correct, people followed it 92.7% of the time. When it was wrong, they still followed it 79.8% of the time. Without AI, baseline accuracy was 45.8%. With correct AI, it jumped to 71.0%. With incorrect AI, it dropped to 31.5%, worse than having no AI. Access to AI also boosted confidence by 11.7 percentage points, even when the answers were wrong. Human review is supposed to be the safety net. But this research suggests the safety net has a hole in it: people do not just miss bad AI output; they become more confident in it. Time pressure did not eliminate the effect. Incentives and feedback reduced it but did not remove it. And the people most resistant tended to score higher on fluid intelligence and need for cognition. That makes this feel less like a laziness problem and more like a cognitive architecture problem.
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5 minutes before Trump’s announcement: * $1.5B notional worth of S&P500 (ES) futures are bought in a single clip. * $192M notional of oil futures (CL) sold. More than 4x-6x any other trade size during the market close. Insiders profited from his lies in broad daylight!
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this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get
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Jeff Currie from Goldman Sachs is probably the best person I know regarding commodities. His take on oil prices:
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The actual research is wild. Every time you push down a feeling, your brain has to choose between suppressing that emotion and recording what’s happening around you. It picks the suppression. The memory doesn’t get saved. A 2000 Stanford study confirmed this: people told to hide their emotions while watching a film remembered far fewer details than people who just reacted naturally. Suppressing emotions uses up mental energy, and that leaves less brain power for saving new memories. Brain scans show why. A 2012 study found that suppression quiets the hippocampus (your brain’s memory-recording center) right when it should be saving information. The two brain regions that normally team up to lock in memories stop talking to each other. Over time it gets worse. Suppression keeps cortisol (the stress hormone) elevated, and cortisol shrinks the hippocampus. Chronically stressed people can lose 10 to 15% of its volume. Just three weeks of high cortisol can shrink the tiny connection points between brain cells by about 20%. The good news: studies show this shrinkage can partially reverse once stress levels drop. Not necessarily permanent. A Finnish study of 1,137 older adults tracked over roughly a decade found that habitual emotion suppressors had nearly 5x the risk of developing dementia, even after controlling for genetics, smoking, obesity, and education. There’s a better way to handle emotions that doesn’t cost you your memory. It’s called cognitive reappraisal: instead of bottling the feeling, you reframe what’s causing it. (“This meeting isn’t a threat, it’s practice.”) A 2003 Stanford/UC Berkeley study found reappraisers had more positive emotion, better relationships, and higher wellbeing. Suppressors got the opposite on every measure. And reappraisal carries zero memory cost. The difference comes down to timing. Suppression kicks in after the emotion has already fired, so your brain is fighting its own response while simultaneously trying to record the moment. Reappraisal changes how you interpret the situation before the emotion fully activates. Same event, same person, but your hippocampus stays free to do its actual job: recording your life.
SUPRESSING YOUR EMOTIONS CAUSES MEMORY LOSS WTF???
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There’s a tweet for everything
The United States has spent EIGHT TRILLION DOLLARS fighting and policing in the Middle East. Thousands of our Great Soldiers have died or been badly wounded. Millions of people have died on the other side. GOING INTO THE MIDDLE EAST IS THE WORST DECISION EVER MADE.....
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How the tables have turned
Breaking: US has reached out to India for help to reduce oil prices "We have reached out to our friends in India to buy stored Russian oil. That pulls oil into Indian refineries and releases pressure on other global refineries," says US Energy Secretary Chris Wright
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👏
Today, we're introducing Spectre I, the first smart device to stop unwanted audio recordings. We live in a world of always-on listening devices. Smart devices and AI dominate our world in business and private conversations. With Deveillance, you will @be_inaudible.
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Nvm?
Seen this viral tweet about a portable audio jammer? Looks cool, right? It also looks quite similar to 100s products sold on Alibaba & in spy shops for years. Or as DIY kits for $50 in parts. They use ultrasonic noise to overwhelm very close-by microphones. I'm skeptical about the price tag & way it's being marketed, and I'd like to share why: it seems to me that what differentiates this, aside from the privacy-aligned language, are claims that sound to me like they've developed "novel physics" & use AI to detect microphones. This would be extraordinary and would require equally extraordinary proof if true. I suspect that the reality may be more like using WiFi etc to scan for devices. This is not novel physics. The problem: many of the microphones that people are most worried about don't emit wifi or bluetooth etc. Or could be a phone in airplane mode. Etc. Additional issues around ultrasonic jamming? Complex range limitations, issues with room reflections, fabric absorbing emissions from your jammer, obstructions etc.. A phone in a fabric pocket might not be defeated by this device reliably, for example. Critically also: the range of this kind of tech is the distance between the emitter and the microphone. Not between you and the unwanted microphone. So if you are in a normal size room and the microphone is, say, 3 meters from you in the ceiling, or on the other side of the couch, it might well still hear you clearly. Consider asking your friendly local expert in audio, physics, or security before purchasing or investing in this product. I'm not one of those. Source of my understanding: I spent some time a few years ago planning to assemble such a device and read a lot of papers. I may be wrong in my understanding (or missing something!) and would happily correct if I've misunderstood what they are offering. To learn more about this popular and well-known category of object, watch @LinusTech from a year ago youtube.com/watch?v=FyeCn7Hl…
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