Born in Shanghai; Living in California; Working in Science; Shining in Life. Reweeting or like = finding it funny ~~~
San Diego, CA
Joined February 2010
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My great honor to be admitted to @GordonConf “mechanism of membrane transport” session! Catching up with our beloved scientists and meeting new friends, listening to cutting-edge research at a picturesque site. It’s invaluable opportunity for communication and inspiration.
Great advancement in scientists' capability of studying the dynamics of neuronal circuits in behaviors. Congratulations to Don and the team and collaborators!
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @Addgene addgene nature.com/articles/s41592-0…
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, @blsabatini @Kanoski_Lab @vincentw_weng @beherring
Very cool. Bitter sensation and airway protective reflexes are actually mediated by cell types that despite different tissue distribution, share developmental trajectory (pou2f3) and sensory signaling pathway (T2R-TRPM5-Calhm).
✨New paper from my lab out now in @CellCellPress !
We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltext/S0092…
Congratulations to Huanghe!
SGP congratulates Dr. Huanghe Yang on receiving the 2025 Paul F. Cranefield Award for his outstanding paper, “Niclosamide potentiates TMEM16A and induces vasoconstriction” doi.org/10.1085/jgp.20231346…
Alignment between heat activation and agonist activation of an ion channel!! (This study represents one step further in understanding the structural basis for TRP channels’ temperature regulation, from the previous one done with TRPM4, published a year ago also by Juan/Wei labs)!
Convergent Agonist and Heat Activation of Nociceptor TRPM3! Congrats to Juan and Wei and their team! @rigbylab
biorxiv.org/content/10.1101/…
Holy Moly! Incredibly amazing research!
Native GABAA receptor structures from the human brain! Amazing work! Huge congrats to Ryan Hibbs and his team!
nature.com/articles/s41586-0…
Wow!
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It's my great honor to contribute a group of data to the work!
It is always exciting to see the long-sought-after findings that perfectly explain the phenomenon as we hypothesized, but then find something novel that points to the hidden unknown about the new channel.
Epitope tagging with genome editing in mice reveals that the proton channel OTOP1 is apically localized and not restricted to Type III “sour” taste receptor cells jneurosci.org/content/early/…
Congratulations!!!
The @CIRMnews has awarded over $28M to Stuart Lipton and @xinjin for studies on pollution’s role in autism & psychiatric risk genes. Using S-nitrosylation pathways & advanced genomic screens, the projects seek new insights into neuropsychiatric disorders. ow.ly/FrmK50TN9Xa
A little touched to see the silver medalist from my country gave Imane such a warm embrace!
I remembered as a kid reading about Jesse Owens, who won the gold medal in track-and-field at 1936 Olympics, crushing Hitler's propaganda of “Aryan supremacy”.
Now 2024 Paris witnessed Pan make history too!
Visited Acadia National Park after Gordon conference, as I did 8 years ago. The same view at different time and in different weathers (2024 vs 2016) is like the same protein structure of different conformations: You see the dynamics! :P sorry for my nerdy joke…
As an ion channel person, I've found myself learn a lot during this GRC, which is focused on transporters! The conference covers many disciplines in the membrane protein field, engages a variety of new technologies, bridges academia and industry. Thanks Prof Ryan for your hosting
Last day of a fantastic week of science and networking at the #MembraneTransportProteins @GordonConf Huge thanks to my superstar co-chair @DrSusieLIngram1 Love this supportive community including our past, present and future chairs👇@madamscientist
Congratulations~~@xinjin !!!
In the current paper Xin's team "upgraded" her previous in-vivo perturb-seq strategy by switching to AAV vectors from lentiviral vectors and hence greatly improving perturbation efficiency! cell.com/cell/fulltext/S0092…
Congratulations to @DuLuLabs !
Very important work that fills the gap in knowledge in structural basis for thermoregulation of TRP channels!
Physiological temperature drives TRPM4 ligand recognition and gating | Nature
doi.org/10.1038/s41586-024-0…
Thanks for pointing this out!
Also, the stress to apply for residency forces many immigrant scientists to choose to work on research fields with quick and easily-publishable outcomes, avoid adventurous projects. (Green card application evaluate your contribution by citation)
Many people have no idea how these things work.
For example, right now, as a Brazilian, I can't accept invitations to speak at conferences in Europe because my visa to work in the U.S. has expired.
I am not illegal; I have a work contract with the University of California until 2027. Still, I must travel outside the U.S. and get a visa stamp on my passport to allow me to move freely to talk about science.
I have to do this every single year I stay in the U.S. The costs of the visa, traveling, time lost, etc, are all on me. Not every international scientist can handle this.
Does this study point to the new path to understanding how health conditions affect appetite? Wow!!!
Nature research paper: Bitter taste receptor activation by cholesterol and an intracellular tastant go.nature.com/3U7ZW3v
Getting the structural evidence for ‘proteo-lipidic pore’ will open the door to new understanding of ion conduction in many other ion channels :)
Nature research paper: Mechanical activation opens a lipid-lined pore in OSCA ion channels go.nature.com/43IlO8O
