@rigbylab
Joined January 2016
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  • Following202
  • Followers136
High Yield Monolayer Graphene Grids for Near-Atomic Resolution Cryo-Electron Microscopy biorxiv.org/cgi/content/shor… #biorxiv_biophys
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"Amgen said it was forced to make some changes to its R&D programming. Like many other companies, it is opting to close out its neuroscience research." biospace.com/article/amgen-c…

Amgen Closes Out Neuroscience Programs as it Focuses on Long-Term Growth Areas

Chief Financial Officer David Meline said the decision was made in order to provide the financial support to areas that will provide long-term growth for the company.

biospace.com
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Juan Du retweeted
PNCC@CryoEM_PNCC24 Oct 2019
Replying to @rigbylab
@rigbylab's lab from @VAInstitute came to visit @CryoEM_PNCC for some data collection. They got to work with Harry, another PNCC SPOC, who was able to get them 3 structures in different conformations in 3 days. Productive visit!
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Video abstract for our new paper with @RuiZhangWUSTL and @DutcherLab. So many hours of Skype went into this structure... youtu.be/lz4eVJxHdEQ

Structure of the decorated ciliary doublet microtubule

Video abstract for Ma et al. 2019. Cell 179, 1-14DOI:https://doi.o...

youtube.com
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First paper from my lab after entering a new field. Great collaboration with @alanbrownhms and @DutcherLab! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎 cell.com/cell/fulltext/S0092…

Structure of the Decorated Ciliary Doublet Microtubule

Visualizing axonemal microtubules and the proteins that decorate them, on the outside and inside, points to how the underlying periodic architecture supports cilia function.

cell.com
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Sweet new fold!
Protein Data Bank@PDBeurope23 Oct 2019
A new protein fold! The 'cytoplasmic ballast' domain of the P2X7 receptor, published @CellCellPress by @alannaemccarthy, @craigky and @mansoor_steven has a previously unseen fold ebi.ac.uk/pdbe/entry/search/…
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This is Willo. She likes to awoo while she eats. Tonight’s meal was worthy of a gentler, but perhaps more meaningful, second awoo. 13/10
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The structural mechanism of TRP channel temperature gating is uncovered and critically involves membrane lipids. We propose that the temperature sensor is the transmembrane domain. Details@ nature.com/articles/s41594-0… sobolevskylab.org/structural… cuimc.columbia.edu/news/imag… @AppuKum74640209
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Our first @biorxivpreprint is out: Structure of a BAF-like SWI/SNF complex in association with nucleosome. biorxiv.org/content/10.1101/… #cryoem #transcription

Cryo-electron microscopy structure of a nucleosome-bound SWI/SNF chromatin remodeling complex

The multi-subunit chromatin remodeling complex SWI/SNF[1][1]–[3][2] is highly conserved from yeast to humans and plays critical roles in various cellular processes including transcription and DNA...

biorxiv.org
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AMPA receptor Regulation by TARP
This Post is from an account that no longer exists. Learn more
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Cryo-EM structure of the mitochondrial protein-import channel TOM complex from Saccharomyces cerevisiae. biorxiv.org/cgi/content/shor… #bioRxiv
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Full length P2X7 structures by @mansoor_steven @craigky @CryoEM_PNCC and Alanna! Congrats!
Cell@CellCellPress3 Oct 2019
New Article online now at Cell: Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization cell.com/cell/fulltext/S0092…
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Full length P2X7 structures! Congratulations Steve!!
Steven E. Mansoor@mansoor_steven3 Oct 2019
Excited to report that some work we’ve been doing is now online.
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Mechanism of gating and partial agonist action in the glycine receptor biorxiv.org/content/10.1101/…

Mechanism of gating and partial agonist action in the glycine receptor

The glycine receptor is a pentameric, neurotransmitter-activated ion channel that transitions between closed/resting, open and desensitized states. Glycine, a full agonist, produces an open channel...

biorxiv.org
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Structure of a temperature-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii that has a unique architecture and 2-fold symmetry. Details @ rdcu.be/bQ07J sobolevskylab.org/structure-… nature.com/articles/s41467-0… #CryoEM
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Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii disq.us/t/3i89xc5
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nature.com/articles/s41586-0…
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Structural insights into TRPM8 inhibition and desensitization science.sciencemag.org/conte…
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BREAKING: UCSF’s David Julius wins the #BreakthroughPrize in Life Sciences for his groundbreaking work on the neuroscience of pain. Congratulations, David! #UCSFProud ucsf.edu/news/2019/09/415336…

Archive: David Julius Receives $3M Breakthrough Prize for Work on Pain Sensation

Julius received the prize “for discovering molecules, cells, and mechanisms underlying pain sensation.”

ucsf.edu
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