drug developer @genentech | prev phd @mcgillu & @mandllab | immunology • mechanobiology • cell migration 👁🧫👁🔬
San Francisco
Joined February 2022
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connie shen retweeted
Mechanosensing by T cells promotes a tissue-resident memory transcriptional program @NatImmunol @ImmuneVet @MandlLab @mcgillu
nature.com/articles/s41590-0…
connie shen retweeted
T cells must preserve their structural integrity while migrating through dense environments. A central actin pool under confinement balances forward propulsion with shape integrity to protect nucleus from DNA damage @SciImmunology @peepingcells @mandllab
science.org/doi/10.1126/scii…
connie shen retweeted
Huge congratulations to Dr. Connie Shen @peepingcells on delivering an outstanding thesis defense! Our fourth Mandl PhD will soon be leaving the nest, trading cold Montréal for sunny California! ☀️All the best!
connie shen retweeted
Check out our recent publication in collaboration with the Khadra Lab at @mcgillu - where computational modelling 🖥️ and experimental immunology 🔬join forces to study the role of T cell diversity and antigen binding strength on chronic infection clearance! Find out more 👇
>90% of #TCR sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity #Tcells generated by TdT are important for curtailing chronic pathogen replication #PLOSBiology plos.io/3HJKOCl
connie shen retweeted
10 years after I helped generating an Otub1 knock-out mouse model in the @durocherlab, now Dr. @MingyiLuo cracked it down... With the immense help of the @MandlLab, he identified the γ-Subunit Gng2 as a novel substrate of Otub1 in splenic B cells.
tandfonline.com/doi/full/10.…
connie shen retweeted
Wondering what we can learn from the T cell receptor beta sequence about the self-reactivity of a T cell? check out our paper in Cell Systems where we used machine learning to ask this very question👇: cell.com/cell-systems/fullte…
connie shen retweeted
Why do neutrophils have multi-lobed nuclei? 🧐
Does this enable their rapid migration through tight spaces? 🏃♀️💨
In this study, we sought to answer this question experimentally 🔬
Here is what we found 👇
Connie Shen @peepingcells, @MandlLab @mcgillu, @Vrisekoop @UMCUtrecht and colleagues discover that nuclear segmentation allows neutrophils to migrate faster in confined spaces.
Highlight: journals.biologists.com/jcs/…
Report: journals.biologists.com/jcs/…
#OpenAccess #ReadandPublish
connie shen retweeted
Our aMAZ(E)ing #MidweekMovie comes from @peepingcells, @MandlLab, @Vrisekoop and colleagues. They discover that neutrophils with segmented nuclei have a speed advantage when migrating through confinement spaces.
📖@J_Cell_Sci: journals.biologists.com/jcs/…
Why do neutrophils have a uniquely lobulated nucleus?
We used primary human neutrophils with differentially segmented nuclei to examine whether one role is in facilitating migration through tight spaces. Read about it here!
Connie Shen @peepingcells, @MandlLab @mcgillu, @Vrisekoop @UMCUtrecht and colleagues discover that nuclear segmentation allows neutrophils to migrate faster in confined spaces.
Highlight: journals.biologists.com/jcs/…
Report: journals.biologists.com/jcs/…
#OpenAccess #ReadandPublish
Please appreciate the brilliant @J_Cell_Sci research highlight title: Knobbly neutrophil nuclei navigate narrow niches 😍
Submitted! Thank you @CdnImmunol for the travel award to attend @iuis_online congress in Cape Town!
Incredibly excited to visit South Africa and talk immunology with everyone 👩🏻🔬
🚨LAST CHANCE TO SUBMIT YOUR ABSTRACT!🚨
There is less than 1 weeks left to submit abstracts for #IUIS2023 in Cape Town! Don't miss this opportunity to share your research at the largest immunology conference in the world.
Submit at iuis2023.org before May 2nd.
connie shen retweeted
After they learned what everyone studied, two patrons at this little gay bar in Galveston TX started chanting “Cell migration! Cell migration
Surest sign of a successful @GordonConf 😃
connie shen retweeted
Connie & Jeremy enjoying #celllavie2 sbcf.fr/en/event/cell-la-vie… in Paris showing off our newest movies of human neutrophils and T cell crowds.
connie shen retweeted
Last weekend we had a very special event: our first Mandl lab wedding! 😍 Ph.D. student Connie (@peepingcells) got married in Vermont on the shores of Lake Champlain, and she boldly invited the whole lab to come witness it. Congrats Connie! 🥳
connie shen retweeted
One last hurrah in Halifax before we head back to Montreal! Thanks for the great conference @CdnImmunol, we loved our time by the ocean 🌊. The Lachine Canal just isn’t the same 😔
#CSI2022
