Immune cell dynamics, migration, and diversity in cells & people @mcgillu. Account run by an exceptional team of trainee-clowns 🧑🔬🤡, with critical PI input.
Montréal, Québec
Joined June 2022
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Huge congratulations to Dr. Connie Shen @peepingcells on delivering an outstanding thesis defense! Our fourth Mandl PhD will soon be leaving the nest, trading cold Montréal for sunny California! ☀️All the best!
Mandl Lab retweeted
NEW POST ALERT just in time for the start of school! Let's talk about T-cell education. Although the curriculum these immune soldiers undergo has only 2 main topics the process involving this education is intricate and extremely beautiful #ImmunologyForAll
immunothoughts.com/how-our-i…
Check out our recent publication in collaboration with the Khadra Lab at @mcgillu - where computational modelling 🖥️ and experimental immunology 🔬join forces to study the role of T cell diversity and antigen binding strength on chronic infection clearance! Find out more 👇
>90% of #TCR sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity #Tcells generated by TdT are important for curtailing chronic pathogen replication #PLOSBiology plos.io/3HJKOCl
Interestingly, against a chronic fungal infection 🍄that T cells can't clear, both our model and experiments agreed that this TCR diversity didn't offer any extra protection. So, it seems that these low-binding TCRs are useful for certain chronic battles!
Want more details? Dive into the full study here: doi.org/10.1371/journal.pbio… 🔗
Mandl Lab retweeted
First MIM happy hour of the year is tomorrow! Who else is coming? 😎
Le premier 5 à 7 de l'année de MIM est demain! Qui d'autre prévoit y être? 👀
Mandl Lab retweeted
Excited to share a new preprint from our group! Marie-Ève and team demonstrate an unexpected role for NGFR/CD271 in directly suppressing T cell activity!
biorxiv.org/content/10.1101/…
Our PhD student Angela @ImmuneVet co-host of the TWiV podcast with @profvrr recently interviewed @bjesseshapiro and Corinne Maurice with their students Sana Naderi and Anshul Sinha about their cool virus research going on at @mcgillu! @McGillMed 📺bit.ly/3Hb9Aet
And this work featured on the current issue cover! Amazing collaboration with @JohannesTextor @MelicharLab, and the Westermann team
Wondering what we can learn from the T cell receptor beta sequence about the self-reactivity of a T cell? check out our paper in Cell Systems where we used machine learning to ask this very question👇: cell.com/cell-systems/fullte…
Mandl Lab retweeted
First talk of the evening is by Dr. Mandl who will talk about T cell migration 🧫
La première présentation est par Dre Mandl qui va nous parler de migration cellulaire 🔬
